Oscar Martin-Santiago1, Javier Gomez-Pilar2, Alba Lubeiro3, Marta Ayuso4, Jesús Poza5, Roberto Hornero5, Myriam Fernandez6, Sonia Ruiz de Azua6, Cesar Valcarcel6, Vicente Molina7. 1. Psychiatry Service, University Hospital of Palencia, Palencia, Spain. 2. Biomedical Engineering Group, University of Valladolid, Valladolid, Spain. 3. Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain. 4. Neurophysiology Service, University Hospital of Valladolid, Valladolid, Spain. 5. Biomedical Engineering Group, University of Valladolid, Valladolid, Spain; Mathematics Research Institute (IMUVA), University of Valladolid, Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain. 6. Neuroscience Department, University of the Basque Country, Leioa, Spain; Psychiatry Service, University Hospital of Alava, Vitoria, Spain. 7. Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain; Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain. Electronic address: vicente.molina@uva.es.
Abstract
OBJECTIVE: Static deficits in small-world properties of brain networks have been described in clinical psychosis, but task-related modulation of network properties has been scarcely studied. Our aim was to assess the modulation of those properties and its association with subclinical psychosis and cognition in the general population. METHOD: Closeness centrality and small-worldness were compared between pre-stimulus baseline and response windows of an odd-ball task in 200 healthy individuals. The correlation between modulation of network parameters and clinical (scores in the Community Assessment of Psychological Experiences) and cognitive measures (performance in the dimensions included in the Brief Assessment of Cognition in Schizophrenia battery) was analyzed, as well as between these measures and the corresponding network parameters during baseline and response windows during task performance. RESULTS: In the theta band, closeness centrality decreased and small-worldness increased in the response window. Centrality and small-worldness modulation were, respectively, directly and inversely associated with subclinical symptoms. CONCLUSIONS: A widespread modulation of network properties in theta band was observed, with a transient increase of small-worldness during the response window, compatible with a transiently more integrated cortical activity associated to cognition. This supports the relevance of electroencephalography to study of normal and altered cognition and its substrates. A relative deficit in the ability to reorganize brain networks may contribute to subclinical psychotic symptoms.
OBJECTIVE: Static deficits in small-world properties of brain networks have been described in clinical psychosis, but task-related modulation of network properties has been scarcely studied. Our aim was to assess the modulation of those properties and its association with subclinical psychosis and cognition in the general population. METHOD: Closeness centrality and small-worldness were compared between pre-stimulus baseline and response windows of an odd-ball task in 200 healthy individuals. The correlation between modulation of network parameters and clinical (scores in the Community Assessment of Psychological Experiences) and cognitive measures (performance in the dimensions included in the Brief Assessment of Cognition in Schizophrenia battery) was analyzed, as well as between these measures and the corresponding network parameters during baseline and response windows during task performance. RESULTS: In the theta band, closeness centrality decreased and small-worldness increased in the response window. Centrality and small-worldness modulation were, respectively, directly and inversely associated with subclinical symptoms. CONCLUSIONS: A widespread modulation of network properties in theta band was observed, with a transient increase of small-worldness during the response window, compatible with a transiently more integrated cortical activity associated to cognition. This supports the relevance of electroencephalography to study of normal and altered cognition and its substrates. A relative deficit in the ability to reorganize brain networks may contribute to subclinical psychotic symptoms.
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Henar de la Red; Jesús Poza; Pablo Núñez; Roberto Hornero; Vicente Molina Journal: Hum Brain Mapp Date: 2018-04-02 Impact factor: 5.038