Literature DB >> 26615642

[Genotoxic and Mutagenic Properties of Synthetic Betulinic and Betulonic Acids].

T S Frolova, T P Kukina, O I Sinitsyna.   

Abstract

Synthesis of betulinic acid was performed from the birch bark extract (Betula pendula). Betulonic acid was intermediate of the synthesis. Both acids were isolated with purity 95%. Genotoxicity and mutagenicity of obtained compounds were analyzed by Ames test and SOS chromotest, none of these properties have been detected.

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Year:  2015        PMID： 26615642     DOI： 10.1134/s1068162015040056

Source DB:  PubMed          Journal:  Bioorg Khim        ISSN： 0132-3423


  3 in total

1.  Potential antigenotoxicity assessment of Ziziphus jujuba fruit.

Authors:  Priya Goswami; Ritesh Banerjee; Anita Mukherjee
Journal:  Heliyon       Date:  2019-05-18

2.  Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics.

Authors:  Rodrigo Juliano Oliveira; Naiara da Cruz Leite Santos; João Renato Pesarini; Beatriz Carneiro de Oliveira; Claudia Rodrigues Berno; Flávio Henrique Souza de Araújo; Ingridhy Ostaciana Maia Freitas da Silveira; Raquel Oliveira Nascimento; Andréia Conceição Milan Brochado Antoniolli-Silva; Antônio Carlos Duenhas Monreal; Adilson Beatriz; Dênis Pires de Lima; Roberto da Silva Gomes
Journal:  Genet Mol Biol       Date:  2018-02-19       Impact factor: 1.771

3.  Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells.

Authors:  Sen Wang; Kexin Wang; Chundong Zhang; Wanfeng Zhang; Qian Xu; Yitao Wang; Yulin Zhang; Yi Li; Ying Zhang; Huifang Zhu; Fangzhou Song; Yunlong Lei; Youquan Bu
Journal:  Cell Death Dis       Date:  2017-10-05       Impact factor: 8.469
  3 in total

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