N B Mathur1, Devendra K Agarwal. 1. Department of Neonatology, Maulana Azad Medical College, New Delhi, India. Correspondence to: Dr NB Mathur, Director Professor and Head, Department of Neonatology, Maulana Azad Medical College, New Delhi 110 002, India. drnbmathur@gmail.com.
Abstract
OBJECTIVE: To assess the effect of zinc supplementation on neuro-development and growth of preterm neonates. SETTING:Referral neonatal unit of a teaching hospital. DESIGN: Open-labeled Randomized controlled trial. PARTICIPANTS: 100 preterm neonates. INTERVENTION: Participants randomized to receive oral zinc (study group) or not (controls). MAIN OUTCOME MEASURES: Primary: Neuro-development status at 40 weeks post conceptional age and at 3 month corrected age using Amiel-Tison neurologic assessment. Secondary: anthropometry and serum alkaline phosphatase at 3 months corrected age. RESULTS: At 40 weeks post-conceptional age, greater number of zinc supplemented infants demonstrated alertness and attention pattern normal for their age (P=0.02). Higher number of controls showed signs of hyper-excitability at 40 week post-conceptional age (P=0.001) and 3 months corrected age (P=0.003). At 3 month corrected age, mean serum alkaline phosphatase level was significantly higher in the study group compared to controls. CONCLUSION:Zinc supplementation till 3 month corrected age in preterm breastfed infants improves alertness and attention pattern; and decreases signs of hyperexcitability, and proportion with abnormal reflexes.
RCT Entities:
OBJECTIVE: To assess the effect of zinc supplementation on neuro-development and growth of preterm neonates. SETTING: Referral neonatal unit of a teaching hospital. DESIGN: Open-labeled Randomized controlled trial. PARTICIPANTS: 100 preterm neonates. INTERVENTION: Participants randomized to receive oral zinc (study group) or not (controls). MAIN OUTCOME MEASURES: Primary: Neuro-development status at 40 weeks post conceptional age and at 3 month corrected age using Amiel-Tison neurologic assessment. Secondary: anthropometry and serum alkaline phosphatase at 3 months corrected age. RESULTS: At 40 weeks post-conceptional age, greater number of zinc supplemented infants demonstrated alertness and attention pattern normal for their age (P=0.02). Higher number of controls showed signs of hyper-excitability at 40 week post-conceptional age (P=0.001) and 3 months corrected age (P=0.003). At 3 month corrected age, mean serum alkaline phosphatase level was significantly higher in the study group compared to controls. CONCLUSION: Zinc supplementation till 3 month corrected age in preterm breastfed infants improves alertness and attention pattern; and decreases signs of hyperexcitability, and proportion with abnormal reflexes.
Authors: Sarah U Morton; Brian J Leyshon; Eleonora Tamilia; Rutvi Vyas; Michaela Sisitsky; Imran Ladha; John B Lasekan; Matthew J Kuchan; P Ellen Grant; Yangming Ou Journal: Front Psychiatry Date: 2022-06-23 Impact factor: 5.435
Authors: Britta Anna Kühne; Paula Vázquez-Aristizabal; Mercè Fuentes-Amell; Laura Pla; Carla Loreiro; Jesús Gómez-Catalán; Eduard Gratacós; Miriam Illa; Marta Barenys Journal: Biomedicines Date: 2022-05-23