Literature DB >> 26614783

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Katy J Petherick, Owen J L Conway, Chido Mpamhanga, Simon A Osborne, Ahmad Kamal, Barbara Saxty, Ian G Ganley.   

Abstract

Entities:  

Year:  2015        PMID： 26614783      PMCID： PMC4661389          DOI： 10.1074/jbc.A114.627778

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  35 in total

Review 1.  Relevance of autophagy to fatty liver diseases and potential therapeutic applications.

Authors:  Shengmin Yan; Nazmul Huda; Bilon Khambu; Xiao-Ming Yin
Journal:  Amino Acids       Date:  2017-05-06       Impact factor: 3.520

Review 2.  Autophagy as a mechanism for anti-angiogenic therapy resistance.

Authors:  Ankush Chandra; Jonathan Rick; Garima Yagnik; Manish K Aghi
Journal:  Semin Cancer Biol       Date:  2019-08-28       Impact factor: 15.707

3.  Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast.

Authors:  Peng Sun; Zaixuan Zhong; Qianyi Lu; Mei Li; Xue Chao; Dan Chen; Wenyan Hu; Rongzhen Luo; Jiehua He
Journal:  Mod Pathol       Date:  2020-05-01       Impact factor: 7.842

4.  Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

Authors:  Themis Alissafi; Aggelos Banos; Louis Boon; Tim Sparwasser; Alessandra Ghigo; Kajsa Wing; Dimitrios Vassilopoulos; Dimitrios Boumpas; Triantafyllos Chavakis; Ken Cadwell; Panayotis Verginis
Journal:  J Clin Invest       Date:  2017-06-05       Impact factor: 14.808

5.  Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR.

Authors:  Fangyang Wang; Damián Gatica; Zhang Xiao Ying; Luke F Peterson; Peter Kim; Denzil Bernard; Kamlai Saiya-Cork; Shaomeng Wang; Mark S Kaminski; Alfred E Chang; Tycel Phillips; Daniel J Klionsky; Sami N Malek
Journal:  J Clin Invest       Date:  2019-03-04       Impact factor: 14.808

6.  Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death.

Authors:  Ohood A Radhi; Scott Davidson; Fiona Scott; Run X Zeng; D Heulyn Jones; Nicholas C O Tomkinson; Jun Yu; Edmond Y W Chan
Journal:  J Biol Chem       Date:  2019-08-06       Impact factor: 5.157

7.  AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance.

Authors:  Irene Benito-Cuesta; Lara Ordóñez-Gutiérrez; Francisco Wandosell
Journal:  Autophagy       Date:  2020-02-20       Impact factor: 16.016

8.  ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer.

Authors:  Jiehui Deng; Aatish Thennavan; Igor Dolgalev; Ting Chen; Jie Li; Antonio Marzio; John T Poirier; David H Peng; Mirna Bulatovic; Subhadip Mukhopadhyay; Heather Silver; Eleni Papadopoulos; Val Pyon; Cassandra Thakurdin; Han Han; Fei Li; Shuai Li; Hailin Ding; Hai Hu; Yuanwang Pan; Vajira Weerasekara; Baishan Jiang; Eric S Wang; Ian Ahearn; Mark Philips; Thales Papagiannakopoulos; Aristotelis Tsirigos; Eli Rothenberg; Justin Gainor; Gordon J Freeman; Charles M Rudin; Nathanael S Gray; Peter S Hammerman; Michele Pagano; John V Heymach; Charles M Perou; Nabeel Bardeesy; Kwok-Kin Wong
Journal:  Nat Cancer       Date:  2021-05-17

Review 9.  Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients.

Authors:  Jean M Mulcahy Levy; Andrew Thorburn
Journal:  Cell Death Differ       Date:  2019-12-13       Impact factor: 15.828

10.  Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.

Authors:  Thomas John Mercer; Yohei Ohashi; Stefan Boeing; Harold B J Jefferies; Stefano De Tito; Helen Flynn; Shirley Tremel; Wenxin Zhang; Martina Wirth; David Frith; Ambrosius P Snijders; Roger Lee Williams; Sharon A Tooze
Journal:  EMBO J       Date:  2021-06-14       Impact factor: 14.012
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