Contact with the baby following stillbirth and parental mental health and well-being: a systematic review.

OBJECTIVE: To collate and critically appraise extant evidence for the impact of contact with the stillborn infant on parental mental health, well-being and satisfaction.
DESIGN: Systematic review. DATA SOURCES: A structured systematic search was conducted in 13 databases, complemented by hand-searching. STUDY ELIGIBILITY CRITERIA: English language studies providing quantitative comparison of outcomes for parents who held their baby or engaged in other memory-making activities, such as having photos and handprints, compared to those who did not, were eligible for inclusion. OUTCOME MEASURES: Primary outcomes included clinically diagnosed mental health issues, standardised assessment of mental health issues or self-reported psychological distress. Secondary outcomes included poor health, relationship difficulties and satisfaction with the decision to have contact with the baby.
RESULTS: Two authors independently screened abstracts, selected potentially eligible studies, extracted data and evaluated the quality of included papers. 11 eligible studies, reported in 18 papers, were included. Studies were heterogeneous, precluding quantitative synthesis, thus a narrative synthesis is presented. Studies presented high risks of bias, particularly in regard to sample representativeness, and confounder identification and adjustment. Results were mixed concerning the impact of holding the stillborn baby on mental health and well-being. One study found no significant effects, and two studies reported no impact on depression. Conflicting effects were found for anxiety and post-traumatic stress. Other memory-making activities were not found to have a significant association with mental health or well-being outcomes. Across studies, mothers were satisfied with their decision to hold their baby or engage in other memory making.
CONCLUSIONS: Evidence for the impact of holding the stillborn baby on mental health and well-being is sparse, and of poor quality. High-quality research guided by a priori hypotheses, with attention to potential confounders and moderating effects, is needed to provide more rigorous evidence to guide practitioners' and parents' decision-making for care following stillbirth. REVIEW PROTOCOL NUMBER: PROSPERO CRD42014013890. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This review is the first to collate and critically appraise extant evidence for the impact of contact with the stillborn infant on parental mental health, well-being and satisfaction.

Sparse, conflicting evidence was found for the impact of holding the stillborn baby on maternal mental health and well-being, in the short and long term.

Systematic searching identified no studies addressing the impact of contact with the stillborn baby on partners’ mental health outcomes.

Included studies consistently suggested that mothers were satisfied with their decision to hold the stillborn baby.

While this review provides quality appraisal of included studies, risk of bias assessment for non-randomised studies remains controversial and consensus for quality appraisal items is yet to be reached.

Introduction

Stillbirth occurs in around 1 in 200 pregnancies in high-income countries.1 Perinatal loss is a devastating and traumatic event for women and their partners. The grief and distress experienced by parents has been documented across qualitative and quantitative studies.2–6 Recent investigation of parents’ experiences in the UK has emphasised the importance of the management of stillbirth and provision of care at this difficult time, reporting that care providers had ‘only one chance to get it right’.7

Standard care for parents during and after stillbirth has varied over time. Traditionally, parents did not see or hold their baby, which was taken away immediately after birth.8 9 This approach received considerable criticism, and policies were changed to support parents to have contact with their baby, make memories and generate mementoes.9 10 Qualitative studies found this to be a positive change. Mothers and fathers have both reported that the opportunity to see and hold their baby, and assistance to create memories, was invaluable.7 11–13 Despite support from the qualitative literature, quantitative data on the impact of contact with the baby after stillbirth are sparse, and mixed findings have been noted.14 This has led to confusion regarding the best evidence-based care for parents in this situation. Clinical guidelines have differed in the recommendations provided. The National Institute for Health and Care Excellence (NICE) 2007 guidelines were criticised for recommending that mothers ‘should not be routinely encouraged to see and hold the dead infant’.7 10 13–16 The most recent guidelines17 have removed this recommendation, rather stating that the option to see, hold and have mementos of the baby should be discussed with women and facilitated by practitioners. Similarly, the Royal College of Obstetricians and Gynaecologists18 noted mixed evidence for the impact of holding the stillborn baby but recommends supporting the wish to do so when expressed, and, in Australia, Queensland Maternity and Neonatal Clinical Guidelines19 advise offering parents and relatives the option to hold their baby after stillbirth. To date, guidelines have been based on mixed qualitative and quantitative evidence.14 17 Extant evidence for the effects of holding the stillborn baby has yet to be collated, and the quality of this evidence appraised. This review seeks to fill this gap, and to appraise and summarise current knowledge regarding the impact of holding the stillborn baby, and of additional memory-making activities.

Outcome and moderator selection

One source of disparity between qualitative and quantitative reports suggesting negative effects of maternal contact with the stillborn baby may be the outcomes considered. Qualitative reports have typically focused on satisfaction, feelings of connectedness, and the emotional experience of mothers and fathers,12 13 whereas quantitative studies have assessed either short or long-term distress manifested in anxiety and mental health issues.20–22 All of these psychological, satisfaction and parental preference outcomes are critical to consider in presenting parents with high-quality evidence with which to make an informed choice about their care,23 and in the development of clinical guidelines. Similarly, short-term and long-term outcomes must be considered in generating a more complete understanding of the impact of infant contact over time.3

Further, studies have suggested that characteristics such as the way the stillbirth was managed, characteristics of the baby, or maternal characteristics, may impact the association between contact and outcomes. Cacciatore et al22 found that, for women who were currently pregnant, having held their previous stillborn infant was associated with increased anxiety, but that this effect was reversed for women who were not currently pregnant. Subsequent live births may also moderate any long-term effects, although this has not been investigated.

The gestation of the stillborn baby has been identified as influencing both whether parents had contact with the baby, as well as the association between contact and outcomes.22 21 Such differences may be attributable to a range of factors including attachment to the unborn child, staff expectations regarding contact and the condition of the baby. Indeed, the physicality of the baby who was stillborn has been identified in qualitative research as a significant concern for parents,13 and may itself moderate effects. Thus the condition of the baby, reasons for fetal death (eg, congenital anomaly) and the time from fetal death to delivery, could all be hypothesised to affect the short-term and long-term distress that may be caused by holding the stillborn baby. Finally, consistent with parents’ emphasis on the importance of care provider support in all aspects of stillbirth,6 the way in which contact is facilitated by staff may be an important aspect of the experience.14 An online survey of 840 mothers found that women felt more comfortable and less fearful when the infant was given to them to hold as a normal part of the birth process, in contrast to mothers who were first asked if they wanted to hold the baby.24 Staff support and facilitation of having time to hold the baby, and in assisting the collecting of mementoes, may all contribute to the experience at this critical time.7

Past reviews

Koopmans et al14 conducted a systematic review of support practices for parents after perinatal death, including contact with the stillborn baby. As their eligibility criteria included randomised controlled trials (RCTs) only, no studies were included. RCTs are the most rigorous and, if well conducted, present the lowest risk of bias. However, RCTs could not ethically be used to assess the impact of holding the stillborn baby, or of memory-making activities. Thus the present review used more inclusive criteria to present an evaluation of best available evidence.

Objectives

The purpose of this review was to collate and critically appraise extant evidence for the impact of contact with the stillborn infant on parental mental health, well-being and satisfaction. Further, this review seeks to highlight moderating factors, drawn from the literature, that may influence the relationship between contact with the infant and outcomes.21 22 24

Methods

The protocol for this review was registered on PROSPERO (CRD42014013890) and is available online (https://www.npeu.ox.ac.uk/listeningtoparents). The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group guidelines25 and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement26 were used to guide the review and reporting.

Inclusion criteria

The primary intervention of interest was whether parents held their stillborn baby in the hours or days after birth. Rates of seeing the stillborn infant were recorded in data extraction, but were anticipated to be near universal, and so outcomes between these groups were not compared. Other activities that parents may undertake to build memories were included as secondary interventions. The selection of holding the baby as the primary intervention reflects the primacy of this practice in debate and controversies surrounding clinical guidance,13–19 and a preliminary review of the literature revealed that most studies focused on comparisons of holding.

Studies were included if they quantitatively compared outcomes for women or their partners who held or did not hold their stillborn baby. Studies were also included if they reported on other memory-making activities. RCTs, and prospective and retrospective cohort and case–control studies were eligible, as were cross-sectional studies. We included studies of all women and partners who had a singleton or multiple stillbirths. The definition of stillbirth differs across jurisdictions, with lower thresholds varying from 18 to 28 weeks’ gestation.27 In at least one prominent study of stillbirth contact and outcomes, a lower bound of 18 weeks was employed.20 It was not expected that first trimester loss (<13 weeks) would be defined as stillbirth in any studies of infant contact, thus this study was excluded. Beyond this very low threshold, we prioritised inclusivity in the review and studies were not excluded based on the gestational definition of stillbirth. Gestation was noted in study data extraction and considered an important moderator of effects. Recognising that studies of infant holding and contact may also include neonatal deaths, where >75% of the sample were stillbirths, studies were eligible for inclusion, and the proportion and outcomes included for parents who had a neonatal death were noted.

Primary outcomes

Mental health was the primary outcome of interest, presented by level of measure validity.

Clinically diagnosed mental health issues, for example, depression, anxiety, post-traumatic stress disorder (PTSD)

Standardised assessment of mental health issues, for example, Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory, Depression Anxiety Stress Scales

Self-reported poor mental health or symptoms of psychological distress

Secondary outcomes

Secondary outcomes reflected more general measures of well-being and relationships. Satisfaction with the contact decision was also included as a secondary outcome.

Self-reported measures of poor maternal/partner health identified by stakeholder user groups:28

Poor physical health

Fatigue or severe tiredness

Sleep problems

Personal relationship difficulties

Satisfaction with contact decision including:

Satisfaction with decision to hold or not to hold the stillborn baby

Satisfaction with the decision to have each additional memory-making activity (eg, satisfaction with decision to bathe baby)

Search methods

The search strategy was developed based on inclusion criteria. In addition, the search strategies reported in a recent qualitative synthesis6 were consulted, as was the Cochrane Pregnancy and Childbirth Group specialised register MeSH terms.

No restrictions were set by date, publication type or language, although resource constraints meant that translation was only available for a limited range of languages. Searches were conducted in July 2015.

The following databases were searched from inception to present:

Applied Social Science Index and Abstracts (ASSIA)

British Nursing Index (BNI)

Cochrane Database of Systematic Reviews

Cochrane Pregnancy and Childbirth Group Trial Register

Cumulative Index to Nursing and Allied Health (CINAHL) plus

EMBASE

Health Services Research Projects in Progress (HSRProj)

MEDLINE

Open Grey

PsycINFO

ProQuest Dissertations and Theses

Science Citation Index

Social Sciences Citation Index

The search strategy for MEDLINE is displayed in box 1 and was adapted for the other databases.

Search #1: Exp stillbirth/OR exp fetal death/OR abortion, spontaneous/OR perinatal mortality/OR (‘fetus death’ OR ‘fetus loss’ OR ‘foetal loss’ OR ‘foetal death’ OR ‘fetal death’ OR ‘fetal loss’ OR ‘neonat* death’ OR ‘neonatal loss’ OR ‘newborn death’ OR ‘newborn loss’ OR ‘perinatal death’ OR ‘perinatal loss*’ OR ‘pregnanc* loss*’ OR ‘stillb*’ OR ‘still born’ OR ‘still birth)’.mp.

Search #2: Exp maternal behavior/OR paternal behavior/OR touch/OR rooming-in care/OR

(contact OR held OR hold* OR touch* OR bath OR bathing OR ‘care practice*’ OR ‘care guideline*’ OR footprint* OR handprint* OR memory OR memories OR momento OR photograph* OR policy OR policies OR ‘psychosocial care’ OR wash OR washing).mp.

Search #3: Exp adaptation, psychological/OR exp anxiety/OR exp anxiety disorders/OR Exp depression/OR exp depression postpartum/OR depressive disorder/OR Exp mood disorders/OR exp grief/OR Exp mental health/OR mental disorders/OR Adjustment Disorders/OR exp stress disorders, post-traumatic/OR stress, psychological/OR sleep disorders/OR ‘sleep initiation and maintenance disorders’/OR (adjustment OR anxi* OR coping OR depress* OR distress OR divorce OR fatigue OR ‘interpersonal difficult*’ OR ‘interpersonal problem*’ OR ‘interpersonal trouble*’ OR ‘insomnia’ OR ‘mental health’ OR ‘mental disorder’ OR ‘mental illness’ OR ‘physical health’ OR ‘poor sleep’ OR ‘posttraumatic stress’ OR ‘post-traumatic stress’ OR ‘postnatal anxiety’ OR ‘postnatal depression’ OR ‘postpartum anxiety’ OR ‘postpartum anxiety’ OR ‘puerperal depression’ OR ‘puerperal depression’ OR psychological OR psychosocial OR PTSD OR regret* OR ‘relationship break*’ OR ‘relationship difficult*’ OR ‘relationship dissolution’ OR ‘relationship problem*’ OR ‘relationship trouble*’ OR satisfaction OR satisfied OR stress* OR ‘sleep problem*’ OR ‘sleep difficult*’ OR ‘sleeping problem*’ OR ‘sleeping difficult*’ OR tired* OR wellbeing OR ‘well being’ OR ‘well-being)’.mp.

Search #4: Search #1 AND Search #2 AND Search #3

Additional grey literature from the websites of the Stillbirth and Neonatal Death Charity (Sands) and the International Stillbirth Alliance

The reference lists and forward citations of all studies meeting inclusion criteria

Subject experts were contacted to identify unpublished or ongoing research

Study selection, appraisal and synthesis

Titles and abstracts returned from searches were independently screened by two reviewers (JMH and JH), who also independently screened full-text articles. Where there was disagreement, reviewers met to reach consensus, and studies were referred to a third reviewer (MR).

While there are clear guidelines for assessing the risk of bias in RCTs,29 risk of bias assessment for observational research remains controversial.30 The risk of bias and quality of included studies were assessed for this review using a checklist developed based on the items of the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement,31 Critical Appraisal Skills Program32 33 checklists for cohort and case–control trials, and the Newcastle-Ottawa Scales (NOS) for assessing the quality of non-randomised studies,34 based on recent appraisal of quality assessment tools for observational studies.30

The following items were appraised for each study and rated as high, low or unclear risk of bias:

Sample representativeness;

Adequacy of exposure measurement (ie, whether the parents held the stillborn baby or engaged in other memory-making activities);

Incomplete outcome data (attrition bias);

Selective outcome reporting;

Other bias.

Two additional items were appraised to assess group comparability and statistical adjustment for potential confounders:

Comparability of exposed and non-exposed participants;

Adequacy of statistical methods and confounder adjustment.

These two items were rated as high risk (little comparability/no adjustment), moderate risk (comparable/adjusted on demographic characteristics only) or low risk (comparable/adjusted on more specific characteristics for these comparisons, eg, pre-pregnancy mental health issues, mode of delivery). This rating was used to provide a more nuanced appraisal of study quality and is consistent with recent evidence that the results of non-randomised designs more closely approximate those of randomised studies when adjustment is made for relevant area-specific characteristics, rather than for characteristics of convenience such as demographics.35

For each study, two reviewers (JMH and JH) independently appraised study quality. Disagreement was resolved through discussion and referral to the third reviewer (MR). Data were extracted independently by two reviewers.

Data synthesis

Narrative synthesis is presented for included studies as heterogeneity in participants and methods precluded quantitative synthesis.26 29 Standardised measures of effect (ORs, standardised mean differences) were calculated to aid comparison. Where studies had adjusted for potential confounders, adjusted measures of effect are included in preference to crude comparisons. Where outcomes are reported for multiple time points, data are presented for each time point. In addition, measures of effect for key subgroups/proposed moderators (see below) are presented. Standardised measures of effect not reported in studies and calculated by review authors are denoted by footnotes in the tables. Effect sizes were calculated using the Campbell Collaboration online effect size calculator,48 employing study frequencies, means, SD and correlation coefficients. Effect estimates for outcomes compared between those who held and did not hold their stillborn baby, and outcomes compared for other types of contact and memory-making activities are presented separately.

Subgroup comparisons

From a review of the background literature, the following characteristics were hypothesised to influence the association between contact with the stillborn baby and outcomes:

Timing of maternal/paternal outcome assessment since the stillbirth;

Women pregnant at the time of outcome assessment;

Subsequent live birth/s;

Gestation of stillbirth;

Reason for stillbirth, for example, congenital abnormality or other causes;

Time from antepartum death to birth;

Level of support for contact/memory making provided by staff;

Where possible, outcomes were stratified according to these subgroups/moderators, and changes to relationships between contact and outcomes noted.

Results

A total of 1402 unique papers were identified and screened. Figure 1 displays the searching flow chart and reasons for exclusions.26

Figure 1

Study flow chart.

Description of studies

Eleven studies reported in 18 papers were eligible for inclusion. This included 16 peer-reviewed publications and two unpublished dissertations.47 39 One conference abstract was identified providing evidence of an eligible study. The authors were contacted but results and full study detail were unavailable at the time of writing, thus the study was listed as eligible but ongoing.49

The characteristics of the 11 studies included are displayed in table 1.

Table 1

Characteristics of included studies

Study ID	Study type	Date data collected	Location/setting	Time since stillbirth	N	Inclusion criteria	Stillbirth gestations
Bennett et al36	Cross-sectional retrospective telephone survey	2007	Four hospitals in the Boston area, USA	0–5 yearsMean=35 months, SD=20	55	Women identified by maternity care providers as eligible for inclusion. Women <18 years who lost a child to SIDS or had an elective abortion were not recruited	Perinatal loss (from 20 weeks’ gestation to 1 month postpartum)Mean=28 weeks’ gestation
	Type of contact assessed		Holding the infant. Taking photos of the infant
	Eligible outcomes assessed		Perinatal grief scale (PGS50); Inventory of Complicated Grief (ICG51); PTSD (post-traumatic stress disorder) Checklist (PCL52); Brief Symptom Inventory 18 (BSI53). Satisfaction with decision to hold baby
Blood and Cacciatore46	Cross-sectional retrospective online survey	October 2011–April 2012	Primarily US participants	1–54 years (75% within past 6 years)	123	Study included parents of children who had died. Mothers and fathers both included (96% female respondents)	36 ‘late miscarriage’ (15–26 weeks) 87 ‘stillborn or perinatal death’ (27 weeks to 6 days)
	Type of contact assessed		Post mortem photography
	Eligible outcomes assessed		Satisfaction with decision to have post mortem photography
Cacciatore et al22	Cross-sectional retrospective online survey	February 2004–September 2005	USA (72%), UK (11%), Australia (9%), Canada (5%)	<1–3+ years<1 years 51%1–2 years 15%2–3 years 9%>3 years 25%	2292	Volunteers recruited from relevant organisation websites and forums	From 20 weeks’ gestationThird trimester loss 79.5% of the sample
	Type of contact assessed		Holding, dressing/washing the stillborn infant
	Eligible outcomes assessed		Anxiety and depression (25-item Hopkins Symptom Check List, HSCL54). Satisfaction with decision to hold baby
Crawley et al37	Cross-sectional retrospective online survey	February 2010–July 2010	UK	0–10 yearsMean=27.9 months, median=18.5 months	162	Women who were at least 18 years old and gave birth in the UK in the past 10 years to a stillborn baby of at least 20 weeks gestation	From 20 weeks gestationMean=35.4 weeks gestation, median=38, range=20–43 weeks
	Type of contact assessed		Making memories (analyses by ‘number of memory-making activities’). Activities included: seeing baby, holding, naming, holding a funeral, creating memory box, taking photos, scattering ashes, family seeing baby, hand/footprints, taking a lock of hair, dressing the baby, others seeing the baby, bathing the baby, taking the baby home
	Eligible outcomes assessed		Depression and anxiety in the past month (Depression, Anxiety and Stress Scale; DASS-2155).PTSD symptoms in the last month (Post-traumatic Stress Symptom Scale, PTSS56)
Fink47	Cross-sectional retrospective online survey	March 2008–December 2008	Primarily US participants	0–2 years	498	Women at least 18 years of age who had experienced a stillbirth in the past 2 years	Not reported
	Type of contact assessed		Given the opportunity to hold the baby (actual holding not reported). Memory box or received other mementos
	Eligible outcomes assessed		Perinatal Grief Scale (PGS50)
Gravensteen et al38	Cross-sectional retrospective postal survey	2008–2009	Norway (women from 2 hospitals)	5–18 years	101	Women who had a verified diagnosis of stillbirth (≥23 weeks’ gestation or ≥500 g) in a singleton or twin pregnancy between 1 January 1990 and 31 December 2003	From 23 weeks’ gestation
	Type of contact assessed		Holding the infant. Other memory-making activities assessed and proportion engaged in, reported by number of comparisons conducted (activities included: photographs, hand/footprint, naming, memorial or funeral, having the baby buried in a grave)
	Eligible outcomes assessed		Post-traumatic Stress Symptoms (Impact of Event Scale, IES57); subjective well-being (General Health Questionnaire; GHQ-2058); depression (Centre for Epidemiological Studies Depression Scale; CES-D59).Satisfaction with decision to hold baby
Hughes et al2 3 20 39	Longitudinal (although still retrospective with regard to holding), interview and survey	Time 1: not reportedTime 2: not reportedTime 3: October 2003–July 2006	UK (women from 3 district general hospitals)	T1: 10 months–5 years (Median gap between loss and expected delivery date 18.5 months)T2: 1 year after subsequent live birthT3: 6–8 years after subsequent live birth	T1: 65T2: 55T3: 52	Pregnant women (who had subsequent live birth), who had no previous live children Excluded women in treatment for physical or mental illness and those whose stillbirth was the result of elective termination for abnormality	From 18 weeks’ gestation
	Type of contact assessed		Holding the infant. Other contact assessed but comparisons not reported.
	Eligible outcomes assessed		Postnatal depression (Edinburgh Postnatal Depression Scale, EPDS60); anxiety (state scale from the Spielberger State-Trait Anxiety Inventory, STAI61), Depression (Beck Depression Inventory62); Post-traumatic stress (PTSD-1 interview63); Marital satisfaction; Psychological symptoms (DSM-III CID) (T3).
Kuti and Ilesanmi40	Cross-sectional retrospective interviewer-administered questionnaire	January–June 2009	Nigeria (University teaching hospital)	6 months–16 years	45	Women registered for prenatal care who had a previous stillborn infant	Not explicitly reported (Nigerian definition of stillbirth: >1 kg or 28 weeks’ gestation)64
	Type of contact assessed		Holding the infant. Other memory-making activities including: taking photos, obtaining mementos, naming infant.
	Eligible outcomes assessed		Maternal self-assessment of ‘recovery’ from stillbirth. Satisfaction with decision to see/hold infant.
Lasker and Toedter9	Longitudinal interview and survey	1984–1989	Pennsylvania, USA	Interviews at T1: 2 monthsT2: 1 yearT3: 2 years following loss	138 mothers (56 partners)	Women who had attended public or private service provider and who had experienced a pregnancy loss or neonatal death55 women had a stillbirth	From 16 weeks’ gestation
	Type of contact assessed		Holding the infant. Other memory making activities including: taking and keeping pictures, holding a funeral or memorial service
	Eligible outcomes assessed		Perinatal Grief Scale (PGS50). Satisfaction with decision to hold infant and care received.
Rådestad et al21 41–44	Cross-sectional retrospective nationally representative postal questionnaire	October–November 1994	Sweden	3 years post-stillbirth	314	Women who had a singleton stillbirth in Sweden in 1991	From 28 weeks’ gestation
	Type of contact assessed		Holding the infant. Other memory-making activities included: time with the baby, kissed/caressed, dressed the baby, had photo taken, kept token of remembrance
	Eligible outcomes assessed		Anxiety (assessed using both state and trait aspects of the Spielberger State-Trait Anxiety Inventory, STAI61); Depression (Centre for Epidemiological Studies Depression Scale, CES-D59), a range of physical symptoms were also assessed (see table 1)
Rådestad et al45	Cross-sectional retrospective postal questionnaire	2001	Stockholm, Sweden	3 months after discharge	33	Nordic-born women who had a singleton stillbirth	From 22 weeks gestation22–28 weeks 35%, 29+ weeks 65%
	Type of contact assessed		Holding the infant
	Eligible outcomes assessed		Fear, regret, tenderness, warmth, pride, insecurity, discomfort, grief assessed on a Likert-scale from 0 (not at all) to 4 (very much)

Studies were published between 1994 and 2014. The majority of studies were conducted in the USA and the number of participants ranged from 45 to 2292, for a total of 3826 participants across all studies with a median of 123. Designs were primarily cross-sectional retrospective surveys. Studies varied in the primary research question. Some focused on the impact of contact with the infant while others assessed multiple predictors of mental health or well-being, with infant contact included as one of these predictors.

Nine studies included comparisons of the primary intervention (holding the baby) and nine comparisons of secondary (memory making) activities. All studies relied on women's self-report to assess contact with the baby. No studies reported the type (eg, skin-to-skin contact), timing or duration of holding. The proportion of women reporting that they held their stillborn baby varied from 0% in Nigeria, 40 to 94% of women in Sweden.21 Older studies reported lower rates of holding, for example, Lasker and Toedter9 42% and Crawley et al37 93%.

The timing of outcome assessment varied from a few months after the stillbirth to many years later (54 years in one study43). Some studies reported outcomes at a single time point and some did so at multiple time points. Outcomes were typically collapsed across time periods. Gestation of the baby at delivery varied across studies, as did gestation at which the death was defined as stillbirth rather than a miscarriage. Gestations of 16 weeks were included in some studies, including those by Blood and Cacciatore,46 and Lasker and Toedter,9 while others used a 20 or 22 week boundary, and yet others, a later 28 week criterion, including studies by Rådestad and co-authors21 41–44 and Kuti and Ilesanmi.40

Two studies presented comparisons including perinatal loss of up to 6 days, 46 or 1 month, 36 although the majority of both samples were stillbirths.

Most studies assessed one or more mental health outcomes including depression, anxiety and post-traumatic stress symptoms through standardised scales such as the Perinatal Grief Scale (PGS50), Impact of Event Scale (IES57) and the Centre for Epidemiological Studies Depression (CES-D59) Scale. Many studies also investigated the secondary outcome of women's satisfaction with their decision to hold or have other contact with the baby, typically measured through a study-specific, single Likert-scale item. Fewer studies included other secondary outcomes such as physical symptoms or relationship difficulties.

Quality of included studies

An assessment of the strengths and weaknesses of included studies is essential in estimating the reliability of effect sizes presented.65 Risk ratings for aspects of study quality are presented in table 2. Further detail and support for study ratings are provided in online supplementary materials.

Table 2

Risk of bias in included studies

Study ID	Sample representa tiveness*	Adequacy of exposure measurement†	Completeness of outcome data‡	Selective outcome reporting	Other bias	Comparability of exposed and non-exposed participants	Adequacy of statistical methods and confounder adjustment
Bennett et al36	High	Low	Low	Unclear	–	Unclear	High
Blood and Cacciatore46	High	Low	Low	Unclear	–	Unclear	High
Cacciatore et al22	High	Low	Low	Unclear	–	High	Low
Crawley et al37	High	Low	Low	Unclear	High	Unclear	Moderate
Fink47	High	High	Low	Unclear	–	Unclear	High
Gravensteen et al38	High	Low	Low	Unclear	–	Unclear	Moderate
Hughes et al2 3 20 39	High	Low	Low	High	–	Unclear	High
Kuti and Ilesanmi40	High	Low	Low	Unclear	–	Unclear	High
Lasker and Toedter9	High	Low	Low	Unclear	High	Unclear	High
Rådestad et al21 41–44	Low	Low	Low	Unclear	–	Moderate	Low
Rådestad et al45	High	Low	Low	Unclear	–	Unclear	High

*Reflected through adequate recruitment, exclusion criteria, response rates and comparability to wider birthing or stillbirth population.

†Adequacy of the assessment of contact with the stillborn infant. ‡Attrition bias.

Sample representativeness

Sample representativeness reported a ‘high risk of bias’ across most studies. Four studies22 37 46 47 used volunteer samples from stillbirth organisation mailing lists that are likely to represent a much more actively engaged sample. Where sample demographics were compared to the broader birthing population, participants were typically younger and more highly educated. Four studies recruited women from hospitals or birthing centres.9 36 38 40 Reported response rates were often low (Bennett 16%; Gravensteen 31%). The study by Hughes and co-authors2 3 20 39 only included participants who were currently pregnant (time 1) with no previous live children, who went on to have a live birth, and were not in treatment for mental or physical health reasons. Generalisability is highly limited by the specific nature of this group. Only one study (Rådestad and co-authors21 41–44) was considered low risk of bias—a nationwide study of all mothers who had a stillbirth, with a high response rate of 83%.

Adequacy of exposure measurement

All studies assessed contact with the infant through women's retrospective self-report. Given the salience of stillbirth in women's lives, this was considered a reliable and adequate exposure measurement. One study reported whether mothers were given the opportunity to hold their stillborn baby (rather than if they did so).47 No studies clearly defined ‘holding’, and none assessed the timing, type or duration of contact with the baby; doing so could have provided important additional information.66

Incomplete outcome data

As the majority (9/11) of studies were cross-sectional, there was no risk of attrition. In the two longitudinal studies, retention rates were high, representing a low risk of attrition bias.

Selective outcome reporting

Hypotheses and analyses were not pre-specified in any of the studies. It is not possible to determine if measures reported in Methods section represent all data that were collected or only those data reported in Results section. It is therefore unclear whether other results or analyses were excluded. Given the mixture of both positive and negative results, and lack of studies reporting no association, it is probable that selective publication has occurred.

Selective outcome reporting was considered a high risk in one study. Hughes and co-authors2 3 20 39 reported (in text) that corrected analyses for the effect of time since the stillbirth and socioeconomic status revealed the association between infant contact and depression to no longer be significant. However, the figures on which this was based were not reported, and the role of time since the stillbirth and socioeconomic status were not reported in the follow-up at time 3.

Other bias

Two studies were classified as ‘high risk’ of additional bias.9 37 For both studies, this was due to the amalgamation of different types of infant contact, memory-making and other interventions after stillbirth. Analyses in both studies were restricted to this combined predictor variable and thus failed to test the impact of any individual intervention. Combining interventions was analytically inappropriate, demonstrating a lack of theory regarding how or why each intervention might positively or negatively affect mental health and well-being. It is also possible for such strategies to mask selective outcome reporting, where comparisons according to individual interventions were not significant.

Comparability of exposed and non-exposed

The majority of studies (9 of 11) failed to investigate the comparability of mothers who held, or did not hold, their baby. As this comparability was not assessed, studies were classified as ‘at unclear risk of bias’ (see table 2). However, as groups were not randomly assigned it is highly likely that in all of these studies the groups are not comparable. Cacciatore et al22 contrasted demographic as well as study-specific characteristics, and found that exposed and non-exposed participants differed in the timing of their loss, time since the loss and primary ethnicity. Rådestad and co-authors21 41–44 also contrasted groups on a number of demographic and study-specific factors, and found that the groups did not differ according to maternal or baby characteristics (p.424), but did differ in maternal education. This was rated as at a ‘moderate risk of bias’.

Adequacy of statistical methods and confounder adjustment

Seven studies were considered to have a high risk of bias, primarily due to failure to adjust for potential confounders in the relationship between holding the infant, and mental health and well-being outcomes. Most studies presented only univariate analyses (see tables 3 and 4). Cacciatore et al22 and Rådestad and co-authors21 41–44 were rated as ‘low risk of bias’ for confounder adjustment, as differences between the groups were evaluated and any significant factors included in multivariable models for adjustment. Both Crawley et al37 and Gravensteen et al38 included analyses that focused on predictors of post-traumatic stress, and adjusted for many demographic and study-specific factors that differed between those considered to have high levels of Post-traumatic Stress Symptom Scale (PTSS)/PTSD and those who did not. In doing so, these studies adjusted for many potential confounders, but as differences between exposed and non-exposed participants were not assessed, it is possible that important differences were missed. These studies were considered to have a moderate risk of bias.

Table 3

Impact of holding the stillborn baby on primary and secondary outcomes

Study ID	N	Time since stillbirth	Outcomes assessed	Measure of effect*	Adjustment for
Bennett et al36	55	0–5 years, mean=35 months	Complicated Grief (ICG)	d=−0.02 (−0.66 to 0.62)†	None
			PTSD symptoms (PCL)	d=0.17 (−0.47 to 0.81)†
			Depression/anxiety (combined PGS, Brief Symptom Inventory)	d=0.17 (−0.47 to 0.81)†
			Satisfaction with decision to hold baby	Of the 78% of the sample who held their baby, 85% of women reported this to be extremely helpful
Cacciatore et al22	2292	<1–3+ years<1 years 51%1–2 years 15%2–3 years 9%>3 years 25%	Anxiety (HSCL)	Not currently pregnant: OR 0.68 (0.49 to 0.95)Currently pregnant: OR 3.79 (1.42 to 10.1)	Gestation of stillbirth (by trimester)Time since loss
			Depression (HSCL)	Not currently pregnant: OR 0.72 (0.51 to 1.02)Currently pregnant: OR 2.13 (0.90 to 5.06)
			Satisfaction with decision to hold baby	99.5% of 2035 mothers who held their baby were glad they did8.2% of 226 mothers who did not hold their baby were glad they did not; 79.5% wished they had held their baby and 12.3% were ‘indifferent’	None
Crawley et al37	162	0–10 years, median 18.5 months	Depression in the past month (DASS-21)	Authors collapsed comparisons across holding the infant and memory-making activities (including photographs, hand/footprints, creating memory box) as a single variable. Authors reported no relationship between memory-making and mental health outcomes. Data not shown and proportions/effect sizes not reported
			Anxiety in the past month (DASS-21)
			PTSD symptoms in the past month (PSSS)
Gravensteen et al38	101	5–18 years	Post-traumatic Stress Symptoms (IES)IES >20 vs <20 (20 was considered possible clinical case level)	OR 0.17 (0.05 to 0.56)	Maternal age, parity, induced abortion prior to stillbirth
			Satisfaction with decision to hold baby	86% of mothers who held their baby reported ‘it felt good’62% of the mothers who did not hold their baby regretted this decision	None
Hughes et al2 3 20 39	T1: 65T2: 55T3: 52	T1: 10 months to -5 years (median 18.5 months)T2: 1 year after subsequent live birthT3: 6–8 years after subsequent live birth	Depression (EPDS >14)/(EPDS continuous)Depression (BDI, continuous)	T1: OR 4.18 (1.19 to 14.69)/d=0.48 (−0.009 to 0.98)‡T2: d=0.42 (−0.12 to 0.96)‡	None
			Anxiety (STAI state >44)/(continuous)	T1: OR 2.67 (0.87 to 8.17)/d=0.51 (0.01 to 1.00)‡T2: OR 3.83 (0.73 to 20.04)/d=0.43 (−0.10 to 0.99)‡	None
			PTSD-1 interview (diagnosis met)/(continuous)§PTSD (DSM-IV SCID)	T1: OR 4.35 (0.84 to 22.63)/d=0.59 (0.05 to 1.09)‡§T2: (not assessed)/d=1.0 (0.44 to 1.56)‡§T3: d=0.78 (0.21 to 1.35)‡	None
			Marital separation	T3: OR 4.50 (1.23 to 16.49)‡	None
Kuti and Ilesanmi40	45	6 months to 16 years	Maternal self-assessment of ‘recovery’ from stillbirth	No mothers were given the opportunity to hold the baby and thus comparisons could not be conducted
			Satisfaction with decision to hold infant	8 (17.8%) of women wished they had had the opportunity to hold their infant
Lasker and Toedter9	138	T1: 2 monthsT2: 1 yearT3: 2 years	Postnatal grief (PGS)	Postnatal grief outcome was only evaluated using a combined variable representing the total number of interventions, thus the individual impact of any single intervention cannot be determined
			Satisfaction with decision to hold infant (time 1)	Early fetal death (16–28 weeks): no significant difference in satisfaction with decisionLate fetal death (27+ weeks): women who held their baby significantly more satisfied with their decision than women who did not hold their baby (proportions not reported)	None, results split by gestation of stillbirth
Rådestad et al21 41–44	314	3 years	Anxiety (STAI state)	28–37 weeks’ gestation: OR 0.70 (0.30 to 1.66)37+ weeks’ gestation: OR 1.70 (0.34 to 8.62)	None (only education significantly differed between those who held and those who did not)
			Depression (CES-D) (dichotomous, scores above 90th centile)	28–37 weeks’ gestation: OR 0.50 (0.20 to 1.30)37+ weeks’ gestation: OR—(Fisher's exact test, p=0.055)
			Backache, stomach problems, headache, tachycardia, chest pressure, panic attacks, nausea or fainting, weakness, sleep disturbances, situation in home and family, situation at work, health, leisure time, physical fitness, appetite, temper, energy, patience, self-confidence	No significant differences with the exception of: 28–37 weeks’ gestation: stomach problems: OR 0.10 (0.02 to 0.94)37+ weeks’ gestation: headache: OR 0.23 (0.06 to 0.96); sleep OR: 0.28 (0.13 to 0.60)
Rådestad et al45	33	3 months	Fear, regret, tenderness, warmth, pride, insecurity, discomfort, grief	94% of 33 women held their babyWhen holding their baby, all mothers felt tenderness and grief; 94% warmth, 81% pride; 48% insecure, 39% discomfort and 35% fear. The mothers of stillborn babies born before 28 weeks’ gestation experienced more fear and insecurity when they held their baby, but differences were not statistically significant (proportions not reported)	None—follow-up comparisons according to gestation of stillbirth

*Where possible standardised mean differences (d) or ORs and 95% CIs were calculated.

†Calculated using study reported frequencies and correlations.

‡Calculated using study reported mean and SD for continuous outcomes, and study reported frequencies for dichotomous outcomes.

§Based on proportions reported in Hughes et al20 (proportions for time 1 and 2 PTSD differ between refs 3 and 20).

BDI, Beck Depression Inventory; CES-D, Centre for Epidemiological Studies Depression Scale; DASS-21, Depression, Anxiety and Stress Scale; DSM, Diagnostic and Statistical Manual of Mental Disorders; EPDS, Edinburgh Postnatal Depression Scale; HSCL, 25-item Hopkins Symptom Check List; ICG, Inventory of Complicated Grief; IES, Impact of Event Scale; PCL, PTSD Checklist; PGS, perinatal grief scale; PTSD, post-traumatic stress disorder; SCID, Structured Clinical Interview for DSM Disorders; STAI, Spielberger State-Trait Anxiety Inventor.

Table 4

Impact of other contact with the stillborn baby on primary and secondary outcomes

Study ID	N	Time since stillbirth	Outcomes assessed	Measure of effect*	Adjustment for
Bennett et al36	55	0–5 years, mean=35 months	Complicated grief (ICG)	Taking pictures of infant: d=−0.29 (−0.97 to 0.40)†	None
			PTSD symptoms (PCL)	Taking pictures of infant: d=−0.16 (−0.84 to 0.53)†
			Depression/anxiety (combined PGS, BSI)	Taking pictures of infant: d=0.08 (−0.61 to 0.76)†
			Satisfaction with decision to take pictures of the baby	Of the 82% of the sample who had photos taken of their baby, 75% reported this was extremely helpful
Blood and Cacciatore46	123	1–54 years (75% within past 6 years)	Satisfaction with decision to have post mortem photography	Only 9 of 123 parents did not have post mortem photography. Only 1 of the 9 was content not having post-mortem photographs	None
Cacciatore et al22	2292	<1–3+ years<1 years 51%1–2 years 15%2–3 years 9%>3 years 25%	Anxiety (HSCL)	Dressed or washed baby: not currently pregnant: OR 0.88 (0.68 to 1.13)Currently pregnant: OR 1.04 (0.58 to 1.86)	Gestation of stillbirth (by trimester), Maternal age
			Depression (HSCL)	Not currently pregnant: OR 1.02 (0.80 to 1.30)Currently pregnant: OR 0.98 (0.55 to 1.76)
			Satisfaction with decision to wash or dress baby	98.3% of 473 mothers who dressed or washed their stillborn baby were glad they did12.4% of 1784 mother who did not dress or wash their baby were glad they had not. 22.1% were ‘indifferent’ and 65.5% wished they had	None
Crawley et al37	162	0–10 years, Median 18.5 months	Authors collapsed comparisons across holding the infant and memory-making activities (including photographs, hand/footprints, creating memory box) as a single variable. Authors reported no relationship between memory making and outcomes
Fink47	498	0–2 years	Postnatal grief (PGS)	Being given the option to hold the baby was not significantly correlated with PGS (0.04, p>0.05)Bivariate correlations between contact and PGS: memory box: −0.14, p<0.01Hand/footprints: −0.05, p>0.05Pictures: −0.07, p>0.05Lock of hair: −0.01, p>0.05Memory box β=−0.11, p=0.018 in final stepwise regression model	Stepwise regression included: living children, race, pregnancy history, autopsy, hospital disposal, opportunity to talk about baby, clear communication from care providers
Gravensteen et al38	101	5–18 years	Post-traumatic Stress Symptoms (IES)	Having an arranged memorial was not significantly associated with IES scoresOR 0.48 (0.16 to 1.40)
Kuti and Ilesanmi40	45	6 months–16 years	Maternal self-assessment of ‘recovery’ from stillbirth	No mothers were given the opportunity have other contact with the infant
			Satisfaction with other contact with the infant	2 (4.4%) of the women reported wished they had the opportunity to take photos of their infant
Lasker and Toedter9	138	T1: 2 monthsT2: 1 yearT3: 2 years	Postnatal grief (PGS)	Postnatal grief outcome was only evaluated using a combined variable representing the total number of interventions, thus the individual impact of any single intervention cannot be determined
			Satisfaction with decision to have contact with infant (time 1)	Mothers who were given a picture of the baby were more satisfied with this decision, as were those who had a death certificate, and those who named the baby for both those who had an early or late fetal death (proportions not reported)	None, results split by gestation of stillbirth
Rådestad et al21 41–44	314	3 years	Depression (CES-D) (dichotomous, scores above 90th centile)	Not being with the baby as long as wished: RR 6.9 (2.4 to 19.8)Did not kiss or caress baby: RR 2.1 (0.8 to 5.6)Did not dress the baby: RR 1.6 (0.8 to 3.3)Did not keep photo of baby: RR 0.9 (0.2 to 4.6)Did not keep token of remembrance: RR 1.2 (0.4 to 3.3)	Maternal education, employment and marital status

*Where possible standardised mean differences (d) or ORs and 95% CIs were calculated.

†Calculated using study reported frequencies and correlations.

BSI, Brief Symptom Inventory 18; CES-D, Centre for Epidemiological Studies Depression Scale; HSCL, 25-item Hopkins Symptom Check List; ICG, Inventory of Complicated Grief; IES, Impact of Event Scale; PCL, PTSD Checklist; PGS, perinatal grief scale; PTSD, post-traumatic stress disorder.

Impact of contact with the stillborn baby

Eight studies provided comparisons of women who held and did not hold their baby (table 3). One study37 measured this type of contact but only provided analysis by a combined infant contact experience variable. We have retained this study and included reported outcomes, but effect sizes could not be calculated for comparison. Six studies provided comparisons assessing the impact of other contact or memory-making activities on outcomes. No studies reported on clinical diagnosis of mental health conditions, with most reporting on outcomes using standardised assessments. Results are presented below with primary mental health outcomes and secondary well-being outcomes presented together, with few studies reporting on these secondary well-being outcomes. Most studies reported on satisfaction with holding or having other contact with the baby. Results are presented first for the primary intervention of holding the baby after stillbirth, then secondary interventions including the range of other types of contact (such as bathing the baby).

Holding the infant

Mental health and well-being

Five studies compared primary mental health outcomes for those who held or did not hold their baby. One study also provided assessment of secondary outcomes of general health, sleep disturbance, energy and self-confidence21 41–44. One study, of 55 women, found no effect of holding the infant on complicated grief or PTSD symptoms, or on an anxiety/depression measure.47 Rådestad and co-authors21 41–44 found no impact of holding the baby on anxiety (Spielberger State-Trait Anxiety Inventor, STAI) or depression (CES-D), although there were differences in secondary outcomes, with significantly lower odds of stomach problems for mothers with stillbirths at 28–37 weeks, and lower odds of headache or sleep problems for those with stillbirths after 37 weeks. While not emphasised in the paper, it should be noted that the long list of other assessed symptoms (including panic attacks, backache, fatigue, appetite, patience, self-confidence) were not significantly different in the sample of 314 mothers.

Of the studies that did find significant effects on mental health measures, one38 reported significantly decreased odds (OR 0.17, 95% CI 0.05 to 0.56) of post-traumatic stress symptoms at the clinical case level related to holding the baby compared with not, after adjustment for maternal age, parity and induced abortion prior to stillbirth. Another study22 found a significant decrease in the odds of anxiety (OR 0.68, 95% CI 0.49 to 0.95) for women who were not currently pregnant, and no significant impact on depression (OR 0.72, 95% CI 0.90 to 5.06) after adjustment for gestation of stillbirth and the time since stillbirth. Conversely, this study found that, for women who were pregnant at the time of survey, odds of anxiety (OR 3.79, 95% CI 1.42 to 10.1) were higher for those who held their baby, again with no significant association with depression (OR 2.13, 95% CI 0.90 to 5.06), after adjustment22 in the sample of 2292 women.

Hughes and co-authors2 3 20 39 found that, for depression, those who held their stillborn baby had increased odds of an EPDS score above 14 at time 1 (while currently pregnant), although no significant difference was found for mean EPDS score at time 1 or Beck Depression Inventory score at time 2 (1 year after subsequent live birth). For anxiety, continuous state anxiety on the STAI was higher (with a moderate effect size, d=0.51, 95% CI 0.01 to 1.00) at time 1 (currently pregnant) for those who held their infant, but scores at time 2 (1 year after live birth) were not significantly different between those who held and did not hold their baby. PTSD symptoms (from diagnostic interviews) were significantly higher at times 1, 2 and 3 (7–10 years after stillbirth) for women who held their stillborn infant, with moderate to large effect sizes calculated (standardised mean difference ranged from 0.59 to 1.0). These comparisons were not adjusted for potential differences between the groups. The effects of two covariates, socioeconomic status and time since the stillbirth, were reported in the text as reducing the effect on depression at time 1 such that it was no longer significant. Data were not reported after adjustments so reductions in effect sizes could not be calculated. Hughes co-authors2 3 20 39 also reported that the odds of marital separation following stillbirth were significantly higher for women who held their stillborn infant (OR 4.50, 95% CI 1.23 to 16.49). Again, there was no adjustment for potential confounding factors.

Satisfaction

Ratings of satisfaction with the decision to hold the infant were uniform, with all studies that measured this outcome finding higher rates of satisfaction among women who held their stillborn baby (85–99%) compared with those who did not. In addition, Rådestad et al45 reported that while holding their stillborn infant, women retrospectively reported feeling warmth (94%) and pride (81%), although this was mixed with insecurity (48%), discomfort (39%) and fear (35%).

Other contact/memory-making activities

Memory-making activities were not generally associated with a significant difference in mental health and well-being outcomes (table 4). Bennett et al36 reported no significant impact of taking pictures of the infant, and Cacciatore et al22 reported no significant effect of dressing or washing the baby. Fink47 found no significant association between having hand/footprints taken, taking pictures of the baby, or taking a lock of hair, and postnatal grief scores, although there was a small association between creating and having a memory box, and lower grief scores. Gravensteen et al38 found no association between having an arranged memorial and post-traumatic stress symptoms. Rådestad and co-authors21 41–44 reported no difference between those who: kissed or caressed their baby, dressed their baby, kept a photo of their baby or kept another token of remembrance, and depression, after adjustment for maternal education, employment and marital status. There was, however, a significantly higher risk of depression for women who were not with their stillborn baby as long as they wished (risk ratio (RR)=6.9, 95% CI 2.4 to 19.8).21 41–44

Five studies reported on maternal satisfaction with having the additional contact/memory-making activities measured in these studies.9 22 36 40 46 The majority of mothers were glad they had engaged in these activities and reported that this was helpful or that they were satisfied with their decision. Where assessed, those who had not had the opportunity to engage in such memory-making activities reported wishing they had been able to do so (table 4).

Inclusion of moderators and subgroup comparisons

Table 5 summarises whether studies included the subgroups/moderators pre-specified for assessment in this review. Few studies included an assessment of proposed moderators. While studies varied in the timing of outcome assessment (time since the stillbirth), only one study investigated the impact of this timing.2 3 20 39 Not all comparisons were reported, however, and the authors simply stated that time since the stillbirth had no effect on any associations, with the exception of third trimester (time 1) depression, which became non-significant when this factor was included in an analysis of covariance.2 3 20 39 Women's pregnancy status at outcome assessment varied between studies, and was assessed in subgroup analyses by one study, with results reported split by this factor.22 No studies provided an analysis of the influence of a subsequent live birth. Cacciatore et al22 reported that mothers whose babies had congenital anomalies were less likely to see or hold their babies, but that congenital anomalies did not have an effect on any reported analyses and so were not included in results reported in the paper. A number of studies found differential effects of holding the baby according to the gestation of the stillbirth, reported in Results section (table 3).

Table 5

Summary of included moderators/subgroup comparisons

Study ID	Time since stillbirth	Women pregnant at outcome assessment	Subsequent live birth/s	Gestation of stillbirth	Time from antepartum death to birth/ or condition of infant	Level of support for contact provided by staff
Bennett et al36	–	–	–	–	–	–
Blood and Cacciatore46	–	–	–	–	–	–
Cacciatore et al22	–	+	/	/	+	/
Crawley et al37	–	*	–	–	–	–
Fink 47	–	–	–	–	–	–
Gravensteen et al38	–	*	–	–	–	–
Hughes et al2 3 20 39	+	†	‡	–	–	–
Kuti and Ilesanmi40	–	–	–	–	–	–
Lasker and Toedter9	–	–	–	+	–	–
Rådestad et al21 41–44	–	/	/	+	/	/
Rådestad et al45	–	–	–	+	–	–

+, Subgroup comparison or moderation analysis provided. /, variable measured but no subgroup comparison or moderation analysis. –, variable not measured.

*None pregnant at outcome assessment.

†All pregnant at outcome assessment.

‡All women had a subsequent live birth.

Rådestad et al21 reported that mothers who received staff support to hold the baby (by providing encouragement or formally discussing holding the baby) were more likely to do so. While this comparison was provided, the authors did not assess a potential moderating effect of staff support on outcomes.

Discussion

Summary of main results

This review of 11 studies found sparse and conflicting evidence for the impact of holding the stillborn baby on mental health and well-being outcomes. Study quality was generally poor, particularly in sample representativeness, and the adequacy of confounder identification and adjustment. There were mixed results for the impact of holding the stillborn baby on mental health and well-being. One study found no significant effects,36 and two other studies reported no impact on depression after adjustment for confounders.21 22 41–44 Conflicting effects were found for anxiety and post-traumatic stress, with one study reporting increased odds associated with holding the baby,2 3 20 39 one reporting decreased odds of anxiety and post-traumatic stress,38 and one reporting a decrease for those not currently pregnant but an increase for those currently pregnant.22 Significant selection bias and confounding is likely in many of the reported results and effect sizes should therefore be interpreted with caution. Included studies were heterogeneous in approach, and many failed to provide adequate comparisons for the primary intervention and outcomes. Consistent with qualitative evidence,7 11–13 studies consistently found that women were satisfied with their decision to hold their stillborn baby. Given women's clear, high levels of satisfaction with the decision to hold their baby, the equipoise that would be required to conduct randomised trials must be justified. While few studies evaluated the same memory-making activities, current evidence suggests no significant positive or negative impacts of activities such as collecting hand/footprints or taking photos on mental health and well-being outcomes, but women were satisfied with their decision to engage in these activities.

Completeness and availability of evidence

As noted previously, sparse evidence exists for the impact of contact with the stillborn infant on parental outcomes.14 As stillbirth is a relatively rare event, it is unsurprising that sample sizes were small. Most studies also failed to be representative of the wider stillbirth population, with many using volunteers recruited through stillbirth organisation websites or strict eligibility criteria2 3 20 39 that excluded many women. Six moderators/subgroups that may have a significant impact on the relationship between contact and outcomes were explored in this review; few studies measured, and even fewer investigated the effects of these factors.

Support for contact with the stillborn baby was not assessed as a moderator in any studies, but may be important in influencing the nature of this contact and its impact. Furthermore, broader cultural support for holding or other memory-making activities may also be important. Most studies were conducted in high-income country contexts, and results may not translate cross-culturally where expectations and traditions around mourning, for example, differ.

Beyond the moderators discussed, no studies addressed individual factors that may also influence the impact of holding or other memory-making activities on parental outcomes. No studies reported on outcomes for partners, and while one study investigated impacts on relationship satisfaction, no studies looked at whether women held their baby with their partner or alone, or if partners and family were supportive.2 3 20 39

Quality of evidence

This review highlighted a number of difficulties and weaknesses in attempting to provide an adequate assessment of the impact of infant contact in absence of clinical trial evidence. Recruiting a representative and sufficiently large sample for a relatively rare event presents a challenge. The quality of the evidence suffered particularly due to a lack of investigation of characteristics that differed between those who held and did not hold their baby. This led to inadequate confounder adjustment, as it is likely that many factors systematically differed between the two groups.22 21 As random allocation is not possible in these observational studies, greater attention to potential confounders would significantly improve the validity of results presented, and eliminate some alternative explanations for relationships found and the differences between studies.20 22 A stronger theoretical basis for the proposed associations and explication of the pathways through which contact with the infant influences outcomes would provide hypotheses that could be tested and is likely to aid in the assessment of key moderators and potential confounders.

Few studies investigated the role of hypothesised moderators. Future attention to these factors may highlight the conditions under which contact with the stillborn infant may be beneficial or harmful to parents, and provide clearer guidance for clinical practice. In particular, the role of staff and the way in which the baby is presented has significant implications for clinical practice.21

However, while greater attention to confounder adjustment would greatly improve future studies, it should be noted that, even if groups were found to be comparable on measured characteristics or adjustment was made for many relevant variables, it remains possible that differences identified may be attributable to other unknown factors differing between the groups.34

There were a number of strengths in the evidence identified. Cross-sectional designs meant that outcome data were generally complete, and the two longitudinal studies identified had high retention rates.3 9 20

Given the salience of stillbirth and surrounding events to women and partners, and evidence of the reliability of women's self-report regarding events around birth,67–69 information collected from women probably represents the most effective and accurate estimate of whether or not women held their stillborn baby. As noted in the results, no studies clearly defined and assessed the way the infant was held (eg, skin-to-skin, timing or duration). These characteristics have been suggested to influence outcomes for women who held their live newborn, with some evidence of a dose–response effect,66 and it is unclear if this is the case when the baby has died. Future investigation of these factors may be important in clarifying effects, however, long-term recall regarding the duration or timing of holding may be less accurate.69

While no studies used clinical diagnosis of mental health problems as an outcome, this may not be feasible in studies with large sample sizes. A strength of the included studies was that most used validated, well-known measures of mental health outcomes. This aided comparability, although the wide variety of such scales meant few studies used the same instrument, which made comparing outcomes more challenging, with each included scale having associated strengths and weaknesses. While these scales are useful for comparability across studies, the use of clinical psychological symptomatology could be questioned. These measures are typically designed to assess pathology, and it could be argued that more subtle changes in quality of life, grief or more general well-being may also be important to consider. Validated measures of quality of life may represent a useful additional outcome in future studies.

There is no evidence regarding the impact of holding the stillborn infant on fathers and partners. Evidence suggests that they are also highly affected by a stillbirth,12 70 and future work is needed to address this deficit.

Strengths and weaknesses of the review

This review is the first to collate, summarise and appraise the available evidence of the impact of holding the stillborn baby on parental mental health, well-being and satisfaction. While assessment of risk of bias is controversial for the evaluation of non-randomised designs, the use of a robust quality appraisal framework based on established risk of bias assessment for randomised trials and critical appraisal tools for non-randomised studies30 34 65 was a significant strength of the present review. Reviews of non-randomised studies have often failed to provide thorough study quality appraisal, which is essential in determining the rigour of included studies and the amount of confidence readers may place in the effect sizes presented. While thorough quality appraisal was provided, consensus on the items for appraisal required for non-randomised studies is yet to be reached.29 30 65

This review included a comprehensive search of past literature, and searches of peer-reviewed and grey literature, with database searching supplemented by hand-searching references and contacting experts. Two foreign language papers were identified, but resources for translation were unavailable, so it is unclear if these papers would have been eligible for inclusion.

Conclusions

In seeking to provide women and their partners with the best available evidence to make informed decisions about having contact with their stillborn baby, the present review found no clear evidence for the impact of holding the stillborn infant on mental health and well-being outcomes in either direction. The review does support qualitative evidence that suggests this contact is valued by women and that they are retrospectively satisfied with their decisions to do so. Reliable data were sparse regarding other memory-making activities, although present evidence suggests there may be no effect of these activities on short-term or long-term mental health and well-being, and that parents are typically happy with their decision to participate in these activities.

Important hypothesised moderators of these effects are yet to be adequately tested. In particular, the condition of the baby, gestation at stillbirth, and the role of care provider support and the way the baby is presented may all be important moderators of the impact that contact with the baby has on outcomes.

Findings from this review suggest that guideline recommendations suggesting women should or should not be encouraged to hold their stillborn infant15–19 do not reflect current evidence, which provides no clear guidance for practice. Evidence does suggest women have been satisfied with their decision to hold their baby. There is no current evidence for the impact of contact with the stillborn baby on outcomes for partners. Further research in this area is needed coupled with research to provide guidance regarding partners’ contact with their stillborn infant.