Marcela Guerendiain1, Jordi Mayneris-Perxachs2, Rosa Montes3, Gemma López-Belmonte4, Miguel Martín-Matillas5, Ana I Castellote3, Elena Martín-Bautista6, Amelia Martí7, J Alfredo Martínez7, Luis Moreno8, Jesús Mª Garagorri8, Julia Wärnberg9, Javier Caballero10, Ascensión Marcos9, M Carmen López-Sabater11, Cristina Campoy12. 1. Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; University of the Republic, Montevideo, Uruguay. 2. Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. 3. Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Spain. 4. Instituto de Investigación Biosanitaria (Ibs Granada), Department of Paediatrics, University of Granada, Granada, Spain. 5. EURISTIKOS Excellence Centre for Paediatric Research, Granada, Spain; Department of Physical Education and Sport, School of Sport Sciences, University of Granada, Spain. 6. EURISTIKOS Excellence Centre for Paediatric Research, Granada, Spain. 7. CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Spain; Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain. 8. Department of Paediatrics, Radiology and Physical Medicine, University of Zaragoza, Spain. 9. Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain. 10. Biochemical Service, Hospital Reina Sofía, Córdoba, Spain. 11. Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Spain. Electronic address: mclopez@ub.edu. 12. Instituto de Investigación Biosanitaria (Ibs Granada), Department of Paediatrics, University of Granada, Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Granada, Spain.
Abstract
BACKGROUND & AIMS: In vivo and in vitro evidence suggests that antioxidant vitamins and carotenoids may be key factors in the treatment and prevention of obesity and obesity-associated disorders. Hence, the objective of the present study was to determine the relationship between plasma lipid-soluble antioxidant vitamin and carotenoid levels and adiposity and cardio-metabolic risk markers in overweight and obese adolescents participating in a multidisciplinary weight loss programme. METHODS: A therapeutic programme was conducted with 103 adolescents aged 12-17 years old and diagnosed with overweight or obesity. Plasma concentrations of α-tocopherol, retinol, β-carotene and lycopene, anthropometric indicators of general and central adiposity, blood pressure and biochemical parameters were analysed at baseline and at 2 and 6 months of treatment. RESULTS: Lipid-corrected retinol (P < 0.05), β-carotene (P = 0.001) and α-tocopherol (P < 0.001) plasma levels increased significantly, whereas lipid-corrected lycopene levels remained unaltered during the treatment. Anthropometric indicators of adiposity (P < 0.001), blood pressure (P < 0.01) and biochemical parameters (P < 0.05) decreased significantly, whereas fat free mass increased significantly (P < 0.001). These clinical and biochemical improvements were related to changes in plasma lipid-corrected antioxidant vitamin and carotenoid levels. The adolescents who experienced the greatest weight loss also showed the largest decrease in anthropometric indicators of adiposity and biochemical parameters and the highest increase in fat free mass. Weight loss in these adolescents was related to an increase in plasma levels of lipid-corrected α-tocopherol (P = 0.001), β-carotene (P = 0.034) and lycopene (P = 0.019). CONCLUSIONS: Plasma lipid-soluble antioxidant vitamin and carotenoid levels are associated with reduced adiposity, greater weight loss and an improved cardio-metabolic profile in overweight and obese adolescents.
BACKGROUND & AIMS: In vivo and in vitro evidence suggests that antioxidant vitamins and carotenoids may be key factors in the treatment and prevention of obesity and obesity-associated disorders. Hence, the objective of the present study was to determine the relationship between plasma lipid-soluble antioxidant vitamin and carotenoid levels and adiposity and cardio-metabolic risk markers in overweight and obese adolescents participating in a multidisciplinary weight loss programme. METHODS: A therapeutic programme was conducted with 103 adolescents aged 12-17 years old and diagnosed with overweight or obesity. Plasma concentrations of α-tocopherol, retinol, β-carotene and lycopene, anthropometric indicators of general and central adiposity, blood pressure and biochemical parameters were analysed at baseline and at 2 and 6 months of treatment. RESULTS:Lipid-corrected retinol (P < 0.05), β-carotene (P = 0.001) and α-tocopherol (P < 0.001) plasma levels increased significantly, whereas lipid-corrected lycopene levels remained unaltered during the treatment. Anthropometric indicators of adiposity (P < 0.001), blood pressure (P < 0.01) and biochemical parameters (P < 0.05) decreased significantly, whereas fat free mass increased significantly (P < 0.001). These clinical and biochemical improvements were related to changes in plasma lipid-corrected antioxidant vitamin and carotenoid levels. The adolescents who experienced the greatest weight loss also showed the largest decrease in anthropometric indicators of adiposity and biochemical parameters and the highest increase in fat free mass. Weight loss in these adolescents was related to an increase in plasma levels of lipid-corrected α-tocopherol (P = 0.001), β-carotene (P = 0.034) and lycopene (P = 0.019). CONCLUSIONS: Plasma lipid-soluble antioxidant vitamin and carotenoid levels are associated with reduced adiposity, greater weight loss and an improved cardio-metabolic profile in overweight and obese adolescents.
Authors: Miguel Martín-Matillas; Dinalrilan Rocha-Silva; Abel Plaza-Florido; Manuel Delgado-Fernández; Amelia Marti; Pilar De Miguel-Etayo; Luis A Moreno; Ascensión Marcos; Cristina Campoy Journal: Nutrients Date: 2022-08-08 Impact factor: 6.706
Authors: Casandra Madrigal; María José Soto-Méndez; Ángela Hernández-Ruiz; María Dolores Ruiz-López; María de Lourdes Samaniego-Vaesken; Teresa Partearroyo; Gregorio Varela-Moreiras; Ángel Gil Journal: Nutrients Date: 2022-10-05 Impact factor: 6.706