| Literature DB >> 26614195 |
V Crudu1, M Merker2, C Lange3, E Noroc1, E Romancenco1, D Chesov4, G Günther5, S Niemann2.
Abstract
Nosocomial transmission of multidrug-resistant tuberculosis (MDR-TB) was ascertained by 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and spoligotyping at four hospitals in the Republic of Moldova, a high MDR-TB burden country. Overall, 5.1% of patients with pan-susceptible TB at baseline were identified with MDR-TB during in-patient treatment. In 75% of cases, the MDR-TB strain was genetically distinct from the non-MDR-TB strain at baseline, suggesting a high rate of nosocomial transmission of MDR-TB. The highest proportion (40.3%) of follow-up MDR-TB isolates was associated with the M. tuberculosis URAL 163-15 strain.Entities:
Mesh:
Substances:
Year: 2015 PMID: 26614195 DOI: 10.5588/ijtld.15.0327
Source DB: PubMed Journal: Int J Tuberc Lung Dis ISSN: 1027-3719 Impact factor: 2.373