A Moreno-Martínez1, M Casals1, À Orcau1, P Gorrindo2, E Masdeu2, J A Caylà1. 1. Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain; Biomedical Research Consortium of the Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain. 2. Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain.
Abstract
BACKGROUND: Diabetes mellitus (DM) can contribute to the development of tuberculosis (TB). OBJECTIVE: To analyse the prevalence of DM and its associated factors among adults with TB in a large city in an industrialised country. METHODS: This is a population-based study in adults diagnosed with TB between 2000 and 2013 in Barcelona. We studied potentially associated sociodemographic and clinical/epidemiological factors. Logistic regression was used to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). RESULTS: Of 5849 TB patients, 349 (5.9%) had DM. The annual prevalence of DM ranged from 4.0% to 7.2%. Factors associated with DM were being Spanish-born (OR 1.46, 95%CI 1.11-1.96), age ⩾40 years (OR 6.08, 95%CI 4.36-8.66), cavitary patterns on chest X-ray (OR 1.42, 95%CI 1.08-1.86), experiencing more side effects due to anti-tuberculosis treatment (OR 1.86, 95%CI 1.28-2.64) and hospitalisation at the time of diagnosis (OR 1.8, 95%CI 1.40-2.31). Human immunodeficiency virus infection was associated with a lower probability of DM in both subjects with a history of injection drug use (OR 0.27, 95%CI 0.10-0.57) and those without (OR 0.04, 95%CI 0.002-0.19). CONCLUSIONS: DM prevalence among adults with TB in Barcelona is low and remained stable over the 14-year study period. However, TB patients with DM were potentially more infectious and their clinical management was more complicated.
BACKGROUND:Diabetes mellitus (DM) can contribute to the development of tuberculosis (TB). OBJECTIVE: To analyse the prevalence of DM and its associated factors among adults with TB in a large city in an industrialised country. METHODS: This is a population-based study in adults diagnosed with TB between 2000 and 2013 in Barcelona. We studied potentially associated sociodemographic and clinical/epidemiological factors. Logistic regression was used to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). RESULTS: Of 5849 TBpatients, 349 (5.9%) had DM. The annual prevalence of DM ranged from 4.0% to 7.2%. Factors associated with DM were being Spanish-born (OR 1.46, 95%CI 1.11-1.96), age ⩾40 years (OR 6.08, 95%CI 4.36-8.66), cavitary patterns on chest X-ray (OR 1.42, 95%CI 1.08-1.86), experiencing more side effects due to anti-tuberculosis treatment (OR 1.86, 95%CI 1.28-2.64) and hospitalisation at the time of diagnosis (OR 1.8, 95%CI 1.40-2.31). Human immunodeficiency virus infection was associated with a lower probability of DM in both subjects with a history of injection drug use (OR 0.27, 95%CI 0.10-0.57) and those without (OR 0.04, 95%CI 0.002-0.19). CONCLUSIONS:DM prevalence among adults with TB in Barcelona is low and remained stable over the 14-year study period. However, TBpatients with DM were potentially more infectious and their clinical management was more complicated.
Authors: Violeta Antonio-Arques; Josep Franch-Nadal; Antonio Moreno-Martinez; Jordi Real; Àngels Orcau; Didac Mauricio; Manel Mata-Cases; Josep Julve; Elena Navas Mendez; Rai Puig Treserra; Joan Barrot de la Puente; Joan Pau Millet; Jose Luis Del Val García; Bogdan Vlacho; Joan A Caylà Journal: Front Public Health Date: 2022-05-23
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