Alkim Oden Akman1,2, Ozge Basaran3, Derya Ozyoruk4, Unsal Han5, Tulin Sayli6, Nilgun Cakar3. 1. Department of General Pediatrics, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey. alkimakman@gmail.com. 2. Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesi, İrfan Baştuğ Caddesi Ziraat Mahallesi Altındağ, Ankara, Turkey. alkimakman@gmail.com. 3. Department of Pediatric Rheumatology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey. 4. Department of Pediatric Oncology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey. 5. Department of Pathology & Cytology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. 6. Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
Abstract
UNLABELLED: Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. CONCLUSION: MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children. What is Known •Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision. •The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement. What is New •A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. •In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.
UNLABELLED: Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. CONCLUSION:MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children. What is Known •Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision. •The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement. What is New •A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. •In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.
Authors: M Kojima; N Nakamura; N Tsukamoto; A Yokohama; H Itoh; S Kobayashi; M Kashimura; N Masawa; S Nakamura Journal: Lupus Date: 2010-10-21 Impact factor: 2.911
Authors: Angela Dispenzieri; James O Armitage; Matt J Loe; Susan M Geyer; Jake Allred; John K Camoriano; David M Menke; Dennis D Weisenburger; Kay Ristow; Ahmet Dogan; Thomas M Habermann Journal: Am J Hematol Date: 2012-07-13 Impact factor: 10.047