OBJECTIVES: We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. METHODS: A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD). Head biometry and cerebroplacental Doppler were assessed by ultrasound, and brain volumetry, cortical development and metabolism by MRI. RESULTS: Both class A and B CHD fetuses had significant differences in head biometry, brain perfusion, cortical development and brain metabolism compared with controls. However, there was a significant linear tendency for head biometry, cerebral Doppler, volumes, cortical sulcation and metabolic ratios across the three clinical groups, with signs of more severe brain alterations in type A CHD fetuses. CONCLUSIONS: All fetuses with CHD showed significant brain developmental changes, but differences were more pronounced in CHD associated with an expected severe reduction in oxygenated blood supply to the brain.
OBJECTIVES: We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. METHODS: A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD). Head biometry and cerebroplacental Doppler were assessed by ultrasound, and brain volumetry, cortical development and metabolism by MRI. RESULTS: Both class A and B CHD fetuses had significant differences in head biometry, brain perfusion, cortical development and brain metabolism compared with controls. However, there was a significant linear tendency for head biometry, cerebral Doppler, volumes, cortical sulcation and metabolic ratios across the three clinical groups, with signs of more severe brain alterations in type A CHD fetuses. CONCLUSIONS: All fetuses with CHD showed significant brain developmental changes, but differences were more pronounced in CHD associated with an expected severe reduction in oxygenated blood supply to the brain.
Authors: Mirthe J Mebius; Nathalie J E Oostdijk; Sara J Kuik; Arend F Bos; Rolf M F Berger; Caterina M Bilardo; Elisabeth M W Kooi; Hendrik J Ter Horst Journal: Pediatr Res Date: 2018-01-10 Impact factor: 3.756
Authors: Sarah U Morton; Lara Maleyeff; David Wypij; Hyuk Jin Yun; Jane W Newburger; David C Bellinger; Amy E Roberts; Michael J Rivkin; J G Seidman; Christine E Seidman; P Ellen Grant; Kiho Im Journal: Cereb Cortex Date: 2020-03-21 Impact factor: 5.357
Authors: Cynthia M Ortinau; Caitlin K Rollins; Ali Gholipour; Hyuk Jin Yun; Mackenzie Marshall; Borjan Gagoski; Onur Afacan; Kevin Friedman; Wayne Tworetzky; Simon K Warfield; Jane W Newburger; Terrie E Inder; P Ellen Grant; Kiho Im Journal: Cereb Cortex Date: 2019-07-22 Impact factor: 5.357
Authors: Cynthia Hayek; V Rajagopalan; J Meouchy; J Votava-Smith; D Miller; S Del Castillo; A Panigrahy; L Paquette Journal: J Perinatol Date: 2020-06-16 Impact factor: 2.521
Authors: Sarah U Morton; Lara Maleyeff; David Wypij; Hyuk Jin Yun; Caitlin K Rollins; Christopher G Watson; Jane W Newburger; David C Bellinger; Amy E Roberts; Michael J Rivkin; P Ellen Grant; Kiho Im Journal: Cereb Cortex Date: 2021-08-26 Impact factor: 5.357
Authors: Sheila M Everwijn; Jiska F van Bohemen; Nan van Geloven; Fenna A Jansen; Aalbertine K Teunissen; Lieke Rozendaal; Nico Blom; Jan M van Lith; Monique C Haak Journal: Prenat Diagn Date: 2021-09-19 Impact factor: 3.242