Tsai-Ju Chien1, Chia-Yu Liu2, Pin-Hao Ko3, Chung-Hua Hsu4. 1. Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Oncology Department, Zhong-Xing Branch, Taipei City Hospital, Taipei, Taiwan. 2. Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Chinese Medicine and Lin-Sen Branch, Taipei City Hospital, Taipei, Taiwan. 3. National Taiwan University, Taipei, Taiwan. 4. Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Chinese Medicine and Lin-Sen Branch, Taipei City Hospital, Taipei, Taiwan owlherbs@yahoo.com.tw.
Abstract
BACKGROUND: Kuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on cancer cells and involved in the TCM theory of promoting yin-yang balance.Sonce many cancer patients suffer from autonomic dysfunction (AD), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic colon cancer (mCRC) patients with AD. METHODS: We conducted a single-group experiment. Total 52 qualified patients were enrolled. Participants took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were cancer-related symptoms and patient quality of life (QoL). RESULTS: The results showed that the KSY intervention improved AD via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). Cancer-related symptoms and QoL were significantly improved (P < .05). CONCLUSION: The safety and effectiveness of KSY in improving AD in mCRC patients are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.
BACKGROUND: Kuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on cancer cells and involved in the TCM theory of promoting yin-yang balance.Sonce many cancerpatients suffer from autonomic dysfunction (AD), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic colon cancer (mCRC) patients with AD. METHODS: We conducted a single-group experiment. Total 52 qualified patients were enrolled. Participants took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were cancer-related symptoms and patient quality of life (QoL). RESULTS: The results showed that the KSY intervention improved AD via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). Cancer-related symptoms and QoL were significantly improved (P < .05). CONCLUSION: The safety and effectiveness of KSY in improving AD in mCRC patients are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.
Authors: Hwa Min Oh; Young Jin Kang; Sun Hee Kim; Young Soo Lee; Min Kyu Park; Ja Myung Heo; Jin ji Sun; Hyo Jung Kim; Eun Sil Kang; Hye Jung Kim; Han Geuk Seo; Jae Heun Lee; Hye Sook Yun-Choi; Ki Churl Chang Journal: Arch Pharm Res Date: 2005-03 Impact factor: 4.946
Authors: Shi Guang Li; Hai Yong Chen; Chen Sheng Ou-Yang; Xi-Xin Wang; Zhen-Jiang Yang; Yao Tong; William C S Cho Journal: PLoS One Date: 2013-02-28 Impact factor: 3.240