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Literature DB >> 26612573

A motor relay on ciliary tracks.

Abstract

A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.

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Year: 2015 PMID： 26612573 PMCID： PMC4898050 DOI： 10.1038/ncb3279

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

Review 1. Intraflagellar transport.

Authors: Joel L Rosenbaum; George B Witman
Journal: Nat Rev Mol Cell Biol Date: 2002-11 Impact factor: 94.444

Review 2. The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization.

Authors: Jeremy F Reiter; Oliver E Blacque; Michel R Leroux
Journal: EMBO Rep Date: 2012-06-29 Impact factor: 8.807

3. Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of Caenorhabditis elegans.

Authors: Natalia S Morsci; Maureen M Barr
Journal: Curr Biol Date: 2011-07-14 Impact factor: 10.834

Review 4. Teamwork in microtubule motors.

Authors: Roop Mallik; Arpan K Rai; Pradeep Barak; Ashim Rai; Ambarish Kunwar
Journal: Trends Cell Biol Date: 2013-07-20 Impact factor: 20.808

5. The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.

Authors: Robert O'Hagan; Brian P Piasecki; Malan Silva; Prasad Phirke; Ken C Q Nguyen; David H Hall; Peter Swoboda; Maureen M Barr
Journal: Curr Biol Date: 2011-10-06 Impact factor: 10.834

Review 6. Kinesin superfamily proteins and the regulation of microtubule dynamics in morphogenesis.

Authors: Shinsuke Niwa
Journal: Anat Sci Int Date: 2014-10-28 Impact factor: 1.741

7. Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.

Authors: Paul M Jenkins; Toby W Hurd; Lian Zhang; Dyke P McEwen; R Lane Brown; Ben Margolis; Kristen J Verhey; Jeffrey R Martens
Journal: Curr Biol Date: 2006-06-20 Impact factor: 10.834

8. Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons.

Authors: Joshua J Snow; Guangshuo Ou; Amy L Gunnarson; M Regina S Walker; H Mimi Zhou; Ingrid Brust-Mascher; Jonathan M Scholey
Journal: Nat Cell Biol Date: 2004-10-17 Impact factor: 28.824

9. Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.

Authors: Jan Burghoorn; Martijn P J Dekkers; Suzanne Rademakers; Ton de Jong; Rob Willemsen; Gert Jansen
Journal: Proc Natl Acad Sci U S A Date: 2007-04-09 Impact factor: 11.205

10. Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia.

Authors: Corey L Williams; Jeremy C McIntyre; Stephen R Norris; Paul M Jenkins; Lian Zhang; Qinglin Pei; Kristen Verhey; Jeffrey R Martens
Journal: Nat Commun Date: 2014-12-15 Impact factor: 14.919

1 in total

1. Why motor proteins team up - Intraflagellar transport in C. elegans cilia.

Authors: Jona Mijalkovic; Bram Prevo; Erwin J G Peterman
Journal: Worm Date: 2016-03-30

1 in total