Literature DB >> 26612572

Rethinking glutamine addiction.

Abigail S Krall1, Heather R Christofk1.   

Abstract

Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.

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Year:  2015        PMID： 26612572     DOI： 10.1038/ncb3278

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Authors:  David R Wise; Ralph J DeBerardinis; Anthony Mancuso; Nabil Sayed; Xiao-Yong Zhang; Harla K Pfeiffer; Ilana Nissim; Evgueni Daikhin; Marc Yudkoff; Steven B McMahon; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-24       Impact factor: 11.205

2.  The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

Authors:  Jiangbin Ye; Monika Kumanova; Lori S Hart; Kelly Sloane; Haiyan Zhang; Diego N De Panis; Ekaterina Bobrovnikova-Marjon; J Alan Diehl; David Ron; Constantinos Koumenis
Journal:  EMBO J       Date:  2010-05-14       Impact factor: 11.598

3.  Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes.

Authors:  W C Gamberino; D A Berkich; C J Lynch; B Xu; K F LaNoue
Journal:  J Neurochem       Date:  1997-12       Impact factor: 5.372

4.  Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.

Authors:  Jian-Bin Wang; Jon W Erickson; Reina Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F Wilson; Andre L B Ambrosio; Sandra M G Dias; Chi V Dang; Richard A Cerione
Journal:  Cancer Cell       Date:  2010-09-14       Impact factor: 31.743

5.  Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.

Authors:  Tzuling Cheng; Jessica Sudderth; Chendong Yang; Andrew R Mullen; Eunsook S Jin; José M Matés; Ralph J DeBerardinis
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-09       Impact factor: 11.205

6.  Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.

Authors:  Matt I Gross; Susan D Demo; Jennifer B Dennison; Lijing Chen; Tania Chernov-Rogan; Bindu Goyal; Julie R Janes; Guy J Laidig; Evan R Lewis; Jim Li; Andrew L Mackinnon; Francesco Parlati; Mirna L M Rodriguez; Peter J Shwonek; Eric B Sjogren; Timothy F Stanton; Taotao Wang; Jinfu Yang; Frances Zhao; Mark K Bennett
Journal:  Mol Cancer Ther       Date:  2014-02-12       Impact factor: 6.261

7.  An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Authors:  Kıvanç Birsoy; Tim Wang; Walter W Chen; Elizaveta Freinkman; Monther Abu-Remaileh; David M Sabatini
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

8.  Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Authors:  Ji Zhang; Jing Fan; Sriram Venneti; Justin R Cross; Toshimitsu Takagi; Bhavneet Bhinder; Hakim Djaballah; Masayuki Kanai; Emily H Cheng; Alexander R Judkins; Bruce Pawel; Julie Baggs; Sara Cherry; Joshua D Rabinowitz; Craig B Thompson
Journal:  Mol Cell       Date:  2014-09-18       Impact factor: 17.970

9.  Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.

Authors:  Hsiu-Ni Kung; Jeffrey R Marks; Jen-Tsan Chi
Journal:  PLoS Genet       Date:  2011-08-11       Impact factor: 5.917

10.  Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Authors:  Saverio Tardito; Anaïs Oudin; Shafiq U Ahmed; Fred Fack; Olivier Keunen; Liang Zheng; Hrvoje Miletic; Per Øystein Sakariassen; Adam Weinstock; Allon Wagner; Susan L Lindsay; Andreas K Hock; Susan C Barnett; Eytan Ruppin; Svein Harald Mørkve; Morten Lund-Johansen; Anthony J Chalmers; Rolf Bjerkvig; Simone P Niclou; Eyal Gottlieb
Journal:  Nat Cell Biol       Date:  2015-11-23       Impact factor: 28.824
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  16 in total

1.  Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.

Authors:  Clint A Stalnecker; Jon W Erickson; Richard A Cerione
Journal:  J Biol Chem       Date:  2017-02-14       Impact factor: 5.157

2.  PYCR1 regulates glutamine metabolism to construct an immunosuppressive microenvironment for the progression of clear cell renal cell carcinoma.

Authors:  Xiyi Wei; Xi Zhang; Shuai Wang; Yichun Wang; Chengjian Ji; Liangyu Yao; Ninghong Song
Journal:  Am J Cancer Res       Date:  2022-08-15       Impact factor: 5.942

3.  Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc.

Authors:  Robert Fuchs; Anika Stracke; Viktoria Holzmann; Gerfried Luschin-Ebengreuth; Nathalie Meier-Allard; Nadine Ebner; Teresa Maria Lassacher; Markus Absenger-Novak; Eleonore Fröhlich; Matthias Schittmayer; Sara Cano Crespo; Manuel Palacin; Beate Rinner; Ruth Birner-Gruenberger
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-06-15       Impact factor: 4.739

Review 4.  Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance.

Authors:  Ilaria Genovese; Marianna Carinci; Lorenzo Modesti; Gianluca Aguiari; Paolo Pinton; Carlotta Giorgi
Journal:  Int J Mol Sci       Date:  2021-04-30       Impact factor: 5.923

5.  Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS.

Authors:  Frank Gaunitz; Claudia Birkemeyer; Henry Oppermann; Yonghong Ding; Jeevan Sharma; Mandy Berndt Paetz; Jürgen Meixensberger
Journal:  Nutr Metab (Lond)       Date:  2016-10-18       Impact factor: 4.169

6.  pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.

Authors:  James P Caruso; Brandon J Koch; Philip D Benson; Elsa Varughese; Michael D Monterey; Amy E Lee; Ajal M Dave; Sam Kiousis; Andrew E Sloan; Saroj P Mathupala
Journal:  Neoplasia       Date:  2017-01-13       Impact factor: 5.715

7.  Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma.

Authors:  Sojin Kim; Ja Eun Kim; Yong Hwy Kim; Taeyoung Hwang; Sung Kwon Kim; Wen Jun Xu; Jong-Yeon Shin; Jong-Il Kim; Hyoungseon Choi; Hee Chan Kim; Hye Rim Cho; Anna Choi; Tamrin Chowdhury; Youngbeom Seo; Yun-Sik Dho; Jin Wook Kim; Dong Gyu Kim; Sung-Hye Park; Hyeonjin Kim; Seung Hong Choi; Sunghyouk Park; Se-Hoon Lee; Chul-Kee Park
Journal:  Sci Rep       Date:  2017-09-22       Impact factor: 4.379

Review 8.  Cancer heterogeneity is not compatible with one unique cancer cell metabolic map.

Authors:  A Strickaert; M Saiselet; G Dom; X De Deken; J E Dumont; O Feron; P Sonveaux; C Maenhaut
Journal:  Oncogene       Date:  2016-10-31       Impact factor: 9.867

9.  Alterations in brain metabolism and function following administration of low-dose codeine phosphate: 1H-magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging studies.

Authors:  Zhen Cao; Pei-Yin Lin; Zhi-Wei Shen; Ren-Hua Wu; Ye-Yu Xiao
Journal:  Exp Ther Med       Date:  2016-05-18       Impact factor: 2.447

10.  Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors.

Authors:  Raeeka Khamari; Anne Trinh; Pierre Elliott Gabert; Paola Corazao-Rozas; Samuel Riveros-Cruz; Stephane Balayssac; Myriam Malet-Martino; Salim Dekiouk; Marie Joncquel Chevalier Curt; Patrice Maboudou; Guillaume Garçon; Laura Ravasi; Pierre Guerreschi; Laurent Mortier; Bruno Quesnel; Philippe Marchetti; Jerome Kluza
Journal:  Cell Death Dis       Date:  2018-02-27       Impact factor: 8.469
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