Jill S Waibel1, Qing-Sheng Mi2, David Ozog3, Le Qu4, Li Zhou2, Ashley Rudnick1, Firas Al-Niaimi5, Julie Woodward6, Valerie Campos7, Serge Mordon8. 1. Miami Dermatology and Laser Institute, 7800 SW 87th Avenue, Suite B200, Miami, Florida, 33173. 2. Henry Ford Immunology Program, Departments of Dermatology and Internal Medicine, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan, 48202. 3. Henry Ford Immunology Program, Henry Ford Hospital, 3031 W Grand Blvd., Detroit, Michigan, 48202. 4. Henry Ford Immunology Program, Department of Dermatology, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan, 48202. 5. Sk:n Clinic, 144 Harley Street, London, UK. 6. Duke University, 2351 Erwin Rd., Suite 3802, Durham, North Carolina, 27705. 7. Clínica Valéria Campos, Jundiaí, São Paulo, Brazil. 8. INSERM U1189, INSERM, 1 Avenue Oscar Lambret, Lille, France.
Abstract
BACKGROUND AND OBJECTIVE: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. STUDY DESIGN/ MATERIAL AND METHODS: A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation. RESULTS: Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side. CONCLUSION: This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing.
RCT Entities:
BACKGROUND AND OBJECTIVE: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. STUDY DESIGN/ MATERIAL AND METHODS: A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation. RESULTS: Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side. CONCLUSION: This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing.
Authors: Judith Krawinkel; Maria Leilani Torres-Mapa; Kristian Werelius; Alexander Heisterkamp; Stefan Rüttermann; Georgios E Romanos; Susanne Gerhardt-Szép Journal: Materials (Basel) Date: 2016-05-20 Impact factor: 3.623