Literature DB >> 26612212

Autophagy Mediates Tumor Suppression via Cellular Senescence.

Lorenzo Galluzzi1, José Manuel Bravo-San Pedro2, Guido Kroemer3.   

Abstract

Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Keywords:  ATG7; HRAS; LC3; cytoplasmic chromatin fragments; lamin B1; tumor suppression

Mesh：

Year:  2015        PMID： 26612212     DOI： 10.1016/j.tcb.2015.11.001

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  16 in total

1.  RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells.

Authors:  Margie N Sutton; Hailing Yang; Gilbert Y Huang; Caroline Fu; Michael Pontikos; Yan Wang; Weiqun Mao; Lan Pang; Maojie Yang; Jinsong Liu; Jan Parker-Thornburg; Zhen Lu; Robert C Bast
Journal:  Autophagy       Date:  2018-03-21       Impact factor: 16.016

Review 2.  Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms.

Authors:  Alexandra Papoudou-Bai; Eleftheria Hatzimichael; Alexandra Barbouti; Panagiotis Kanavaros
Journal:  Clin Exp Med       Date:  2016-09-06       Impact factor: 3.984

3.  On the relevance of precision autophagy flux control in vivo - Points of departure for clinical translation.

Authors:  Ben Loos; Daniel J Klionsky; Andre Du Toit; Jan-Hendrik S Hofmeyr
Journal:  Autophagy       Date:  2019-11-11       Impact factor: 16.016

4.  Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β.

Authors:  Padmaja Gade; Amy S Kimball; Angela C DiNardo; Priyamvada Gangwal; Douglas D Ross; H Scott Boswell; Susan K Keay; Dhananjaya V Kalvakolanu
Journal:  J Biol Chem       Date:  2016-09-02       Impact factor: 5.157

5.  Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.

Authors:  Xiaoyu Qi; Shuguo Zheng; Mingyue Ma; Naqi Lian; Hongting Wang; Lerong Chen; Anping Song; Chunfeng Lu; Shizhong Zheng; Huanhuan Jin
Journal:  Front Pharmacol       Date:  2022-06-28       Impact factor: 5.988

6.  Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging.

Authors:  Sandeep Singh; Raushan Kumar; Geetika Garg; Abhishek Kumar Singh; Avnish Kumar Verma; Akalabya Bissoyi; Syed Ibrahim Rizvi
Journal:  Biogerontology       Date:  2020-09-26       Impact factor: 4.277

7.  Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway.

Authors:  Elena Y Kochetkova; Galina I Blinova; Olga A Bystrova; Marina G Martynova; Valery A Pospelov; Tatiana V Pospelova
Journal:  Aging (Albany NY)       Date:  2017-11-14       Impact factor: 5.682

8.  TGFβ signaling-induced miRNA participates in autophagic regulation by targeting PRAS40 in mesenchymal subtype of glioblastoma.

Authors:  Yingbin Xie; Luyue Chen; Junhu Zhou; Chao Yang; Can Xu; Xiangyu Fan; Yanli Tan; Yanan Wang; Chunsheng Kang; Chuan Fang
Journal:  Cancer Biol Med       Date:  2020-08-15       Impact factor: 4.248

9.  Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells.

Authors:  Xiaokun Lin; Lei Han; Jialei Weng; Kelai Wang; Tongke Chen
Journal:  Biosci Rep       Date:  2018-11-30       Impact factor: 3.840

10.  Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma.

Authors:  Jia Xie; Xiuhua Xu; Ping Yin; Yinuo Li; Haiyang Guo; Stacy Kujawa; Debabrata Chakravarti; Serdar Bulun; J Julie Kim; Jian-Jun Wei
Journal:  Lab Invest       Date:  2018-09-11       Impact factor: 5.662
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