Literature DB >> 26611672

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

Jelle de Wit1, M Hussein Al-Mossawi2, Michael H Hühn3, Carolina V Arancibia-Cárcamo3, Karen Doig2, Benjamin Kendrick2, Roger Gundle2, Peter Taylor4, Terri Mcclanahan5, Erin Murphy5, Hongjun Zhang6, Ken Barr6, J Richard Miller6, Xiao Hu6, Thomas D Aicher7, Rodney W Morgan7, Gary D Glick8, Dennis Zaller6, Craig Correll6, Fiona Powrie9, Paul Bowness10.   

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Year:  2015        PMID： 26611672     DOI： 10.1016/j.jaci.2015.09.048

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


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  16 in total

1.  Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.

Authors:  Hongjun Zhang; Blair T Lapointe; Neville Anthony; Rita Azevedo; Jos Cals; Craig C Correll; Matthew Daniels; Sujal Deshmukh; Hans van Eenenaam; Heidi Ferguson; Laxminarayan G Hegde; Willem Jan Karstens; John Maclean; J Richard Miller; Lily Y Moy; Vladimir Simov; Sunil Nagpal; Arthur Oubrie; Rachel L Palte; Gopal Parthasarathy; Nunzio Sciammetta; Mario van der Stelt; Janice D Woodhouse; B Wesley Trotter; Kenneth Barr
Journal:  ACS Med Chem Lett       Date:  2020-01-09       Impact factor: 4.345

Review 2.  Pathogenesis of ankylosing spondylitis - recent advances and future directions.

Authors:  Vidya Ranganathan; Eric Gracey; Matthew A Brown; Robert D Inman; Nigil Haroon
Journal:  Nat Rev Rheumatol       Date:  2017-04-27       Impact factor: 20.543

3.  RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.

Authors:  Mingming Sun; Chong He; Liang Chen; Wenjing Yang; Wei Wu; Feidi Chen; Anthony T Cao; Suxia Yao; Sara M Dann; T G Murali Dhar; Luisa Salter-Cid; Qihong Zhao; Zhanju Liu; Yingzi Cong
Journal:  J Immunol       Date:  2018-11-26       Impact factor: 5.422

4.  Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt.

Authors:  Iris A Leijten-van de Gevel; Luc Brunsveld
Journal:  J Biol Chem       Date:  2020-05-20       Impact factor: 5.157

5.  Analysis of the Transcriptional Activity of Retinoic Acid-Related Orphan Receptors (RORs) and Inhibition by Inverse Agonists.

Authors:  Yukimasa Takeda; Hong Soon Kang; Anton M Jetten
Journal:  Methods Mol Biol       Date:  2019

Review 6.  Recent Updates in the Immunopathology of Type 3 Immunity-Mediated Enthesitis.

Authors:  Akihiro Nakamura; Nigil Haroon
Journal:  Curr Rheumatol Rep       Date:  2021-04-24       Impact factor: 4.592

Review 7.  Psoriasis pathogenesis and the development of novel targeted immune therapies.

Authors:  Jason E Hawkes; Tom C Chan; James G Krueger
Journal:  J Allergy Clin Immunol       Date:  2017-09       Impact factor: 10.793

Review 8.  (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.

Authors:  Anton M Jetten; Donald N Cook
Journal:  Annu Rev Pharmacol Toxicol       Date:  2019-08-06       Impact factor: 13.820

9.  The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Authors:  Bernard C Lo; Matthew J Gold; Michael R Hughes; Frann Antignano; Yanet Valdez; Colby Zaph; Kenneth W Harder; Kelly M McNagny
Journal:  Sci Immunol       Date:  2016-09-02

10.  Retinoic acid-related Orphan Receptor γ (RORγ): connecting sterol metabolism to regulation of the immune system and autoimmune disease.

Authors:  Anton M Jetten; Yukimasa Takeda; Andrzej Slominski; Hong Soon Kang
Journal:  Curr Opin Toxicol       Date:  2018-02-01
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