Literature DB >> 26611588

Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling.

Matthew J Benskey1, Fredric P Manfredsson2.   

Abstract

Stereotaxic surgery enables precise and consistent microinjections to discrete neural nuclei. Using stereotaxic surgery to deliver viral vectors is a powerful tool that provides the ability to manipulate gene expression in specific regions, or even specific cell types in the brain. Here, we describe the proper handling and stereotaxic delivery of recombinant adeno-associated virus to various neuroanatomical structures of the rodent brain.

Entities:  

Keywords:  Adeno-associated virus (rAAV ); Brain; Gene delivery; Stereotaxic surgery

Mesh：

Year:  2016        PMID： 26611588     DOI： 10.1007/978-1-4939-3271-9_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.

Authors:  Rhyomi C Sellnow; Kathy Steece-Collier; Feras Altwal; Ivette M Sandoval; Jeffrey H Kordower; Timothy J Collier; Caryl E Sortwell; Anthony R West; Fredric P Manfredsson
Journal:  J Neurosci       Date:  2020-04-01       Impact factor: 6.167

2.  Impact of age and vector construct on striatal and nigral transgene expression.

Authors:  Nicole K Polinski; Fredric P Manfredsson; Matthew J Benskey; D Luke Fischer; Christopher J Kemp; Kathy Steece-Collier; Ivette M Sandoval; Katrina L Paumier; Caryl E Sortwell
Journal:  Mol Ther Methods Clin Dev       Date:  2016-12-07       Impact factor: 6.698

3.  Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.

Authors:  D Luke Fischer; Fredric P Manfredsson; Christopher J Kemp; Allyson Cole-Strauss; Jack W Lipton; Megan F Duffy; Nicole K Polinski; Kathy Steece-Collier; Timothy J Collier; Sara E Gombash; Daniel J Buhlinger; Caryl E Sortwell
Journal:  Sci Rep       Date:  2017-11-27       Impact factor: 4.379

4.  Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS.

Authors:  Nicholas M Kanaan; Rhyomi C Sellnow; Sanford L Boye; Ben Coberly; Antonette Bennett; Mavis Agbandje-McKenna; Caryl E Sortwell; William W Hauswirth; Shannon E Boye; Fredric P Manfredsson
Journal:  Mol Ther Nucleic Acids       Date:  2017-06-21       Impact factor: 8.886

5.  Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.

Authors:  Matthew J Benskey; Rhyomi C Sellnow; Ivette M Sandoval; Caryl E Sortwell; Jack W Lipton; Fredric P Manfredsson
Journal:  Front Mol Neurosci       Date:  2018-02-13       Impact factor: 5.639

6.  Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.

Authors:  Kathy Steece-Collier; Jennifer A Stancati; Nicholas J Collier; Ivette M Sandoval; Natosha M Mercado; Caryl E Sortwell; Timothy J Collier; Fredric P Manfredsson
Journal:  Mov Disord       Date:  2019-04-19       Impact factor: 10.338

7.  Transmission electron microscopic analysis of myelination in the murine central nervous system.

Authors:  Yan Wang; Bo Sun; Bradley Shibata; Fuzheng Guo
Journal:  STAR Protoc       Date:  2022-04-18

8.  Orexin (hypocretin) mediates light-dependent fluctuation of hippocampal function in a diurnal rodent.

Authors:  Joel E Soler; Hang Xiong; Faiez Samad; Fredric P Manfredsson; Alfred J Robison; Antonio A Núñez; Lily Yan
Journal:  Hippocampus       Date:  2021-07-15       Impact factor: 3.753

Review 9.  Current Experimental Studies of Gene Therapy in Parkinson's Disease.

Authors:  Jing-Ya Lin; Cheng-Long Xie; Su-Fang Zhang; Weien Yuan; Zhen-Guo Liu
Journal:  Front Aging Neurosci       Date:  2017-05-03       Impact factor: 5.750

10.  Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia.

Authors:  Rhyomi C Sellnow; Jordan H Newman; Nicole Chambers; Anthony R West; Kathy Steece-Collier; Ivette M Sandoval; Matthew J Benskey; Christopher Bishop; Fredric P Manfredsson
Journal:  Acta Neuropathol Commun       Date:  2019-01-15       Impact factor: 7.801
  10 in total

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