Literature DB >> 26610300

Dual role of arginine metabolism in establishing pathogenesis.

Mayuri Gogoi1, Akshay Datey2, Keith T Wilson3, Dipshikha Chakravortty4.   

Abstract

Arginine is an integral part of host defense when invading pathogens are encountered. The arginine metabolite nitric oxide (NO) confers antimicrobial properties, whereas the metabolite ornithine is utilized for polyamine synthesis. Polyamines are crucial to tissue repair and anti-inflammatory responses. iNOS/arginase balance can determine Th1/Th2 response. Furthermore, the host arginine pool and its metabolites are utilized as energy sources by various pathogens. Apart from its role as an immune modulator, recent studies have also highlighted the therapeutic effects of arginine. This article sheds light upon the roles of arginine metabolism during pathological conditions and its therapeutic potential.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26610300      PMCID： PMC4755812          DOI： 10.1016/j.mib.2015.10.005

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  45 in total

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Journal:  Eur J Immunol       Date:  2015-04-21       Impact factor: 5.532

2.  Macrophage-Microglia Networks Drive M1 Microglia Polarization After Mycobacterium Infection.

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Journal:  Inflammation       Date:  2015-08       Impact factor: 4.092

3.  Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells.

Authors:  M Munder; K Eichmann; J M Morán; F Centeno; G Soler; M Modolell
Journal:  J Immunol       Date:  1999-10-01       Impact factor: 5.422

4.  Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.

Authors:  Andrée Yeramian; Lorena Martin; Luis Arpa; Joan Bertran; Concepció Soler; Carol McLeod; Manuel Modolell; Manuel Palacín; Jorge Lloberas; Antonio Celada
Journal:  Eur J Immunol       Date:  2006-06       Impact factor: 5.532

5.  Helicobacter pylori induces macrophage apoptosis by activation of arginase II.

Authors:  Alain P Gobert; Yulan Cheng; Jian-Ying Wang; Jean-Luc Boucher; Ramaswamy K Iyer; Stephen D Cederbaum; Robert A Casero; Jamie C Newton; Keith T Wilson
Journal:  J Immunol       Date:  2002-05-01       Impact factor: 5.422

Review 6.  Inducible nitric oxide synthase and control of intracellular bacterial pathogens.

Authors:  Dipshikha Chakravortty; Michael Hensel
Journal:  Microbes Infect       Date:  2003-06       Impact factor: 2.700

Review 7.  Role of L-arginine in the pathogenesis and treatment of renal disease.

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Journal:  J Nutr       Date:  2004-10       Impact factor: 4.798

8.  Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation.

Authors:  Françoise I Bussière; Rupesh Chaturvedi; Yulan Cheng; Alain P Gobert; Mohammad Asim; Darren R Blumberg; Hangxiu Xu; Preston Y Kim; Amy Hacker; Robert A Casero; Keith T Wilson
Journal:  J Biol Chem       Date:  2004-11-17       Impact factor: 5.157

9.  L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes.

Authors:  Li Zheng; Yanyan Pan; Yonghui Feng; Liwang Cui; Yaming Cao
Journal:  Parasit Vectors       Date:  2015-06-14       Impact factor: 3.876

Review 10.  A lesson in survival, by Giardia lamblia.

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Journal:  Biophys J       Date:  2021-12-18       Impact factor: 4.033

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Authors:  Erin N S McGowan; Osanna Wong; Eleanor Jones; Julie Nguyen; Janet Wee; Maria C Demaria; Devy Deliyanti; Chad J Johnson; Michael J Hickey; Malcolm J McConville; Jennifer L Wilkinson-Berka; Mark D Wright; Katrina J Binger
Journal:  iScience       Date:  2022-06-03

Review 3.  MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells.

Authors:  Russell G Jones; Edward J Pearce
Journal:  Immunity       Date:  2017-05-16       Impact factor: 31.745

Review 4.  Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer.

Authors:  Eugene W Gerner; Elizabeth Bruckheimer; Alfred Cohen
Journal:  J Biol Chem       Date:  2018-10-24       Impact factor: 5.157

Review 5.  Polyamines in Gut Epithelial Renewal and Barrier Function.

Authors:  Jaladanki N Rao; Lan Xiao; Jian-Ying Wang
Journal:  Physiology (Bethesda)       Date:  2020-09-01

6.  Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

Authors:  Dana M Hardbower; Mohammad Asim; Tracy Murray-Stewart; Robert A Casero; Thomas Verriere; Nuruddeen D Lewis; Rupesh Chaturvedi; M Blanca Piazuelo; Keith T Wilson
Journal:  Amino Acids       Date:  2016-04-13       Impact factor: 3.520

7.  Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis.

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Journal:  Int J Mol Sci       Date:  2021-06-26       Impact factor: 5.923

8.  Spatially resolved analysis of Pseudomonas aeruginosa biofilm proteomes measured by laser ablation sample transfer.

Authors:  Aruni Chathurya Pulukkody; Yeni P Yung; Fabrizio Donnarumma; Kermit K Murray; Ross P Carlson; Luke Hanley
Journal:  PLoS One       Date:  2021-07-22       Impact factor: 3.240

9.  Symbiotic Association with Mycoplasma hominis Can Influence Growth Rate, ATP Production, Cytolysis and Inflammatory Response of Trichomonas vaginalis.

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Journal:  Front Microbiol       Date:  2016-06-20       Impact factor: 5.640

Review 10.  Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity.

Authors:  Daniel Tomé
Journal:  Nutr Diabetes       Date:  2021-06-23       Impact factor: 5.097
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