Marcela Alejandra Cucher1, Natalia Macchiaroli1, Germán Baldi2, Federico Camicia1, Laura Prada1, Lucas Maldonado1, Héctor Gabriel Avila1,3, Adolfo Fox4, Ariana Gutiérrez5, Perla Negro6, Raúl López7, Oscar Jensen3, Mara Rosenzvit1, Laura Kamenetzky1. 1. Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. 2. Estudios Ambientales, Instituto de Matemática Aplicada de San Luis UNSL-CONICET, San Luis, Argentina. 3. Centro de Investigación en Zoonosis, Ministerio de Salud Ministerio de Desarrollo Territorial y Sectores Productivos, Chubut, Argentina. 4. Laboratorios Fox, Santa Fe, Argentina. 5. ANLIS-"Dr Carlos G Malbrán" Instituto Nacional de Enfermedades Infecciosas, Buenos Aires, Argentina. 6. Parasitología y Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, Santa Fe, Argentina. 7. División Zoonosis, Ministerio de Salud y Acción Social, Catamarca, Argentina.
Abstract
OBJECTIVE: To systematically review publications on Echinococcus granulosus sensu lato species/genotypes reported in domestic intermediate and definitive hosts in South America and in human cases worldwide, taking into account those articles where DNA sequencing was performed; and to analyse the density of each type of livestock that can act as intermediate host, and features of medical importance such as cyst organ location. METHODS: Literature search in numerous databases. We included only articles where samples were genotyped by sequencing since to date it is the most accurate method to unambiguously identify all E. granulosus s. l. genotypes. Also, we report new E. granulosus s. l. samples from Argentina and Uruguay analysed by sequencing of cox1 gene. RESULTS: In South America, five countries have cystic echinococcosis cases for which sequencing data are available: Argentina, Brazil, Chile, Peru and Uruguay, adding up 1534 cases. E. granulosus s. s. (G1) accounts for most of the global burden of human and livestock cases. Also, E. canadensis (G6) plays a significant role in human cystic echinococcosis. Likewise, worldwide analysis of human cases showed that 72.9% are caused by E. granulosus s. s. (G1) and 12.2% and 9.6% by E. canadensis G6 and G7, respectively. CONCLUSIONS: E. granulosus s. s. (G1) accounts for most of the global burden followed by E. canadensis (G6 and G7) in South America and worldwide. This information should be taken into account to suit local cystic echinococcosis control and prevention programmes according to each molecular epidemiological situation.
OBJECTIVE: To systematically review publications on Echinococcus granulosus sensu lato species/genotypes reported in domestic intermediate and definitive hosts in South America and in human cases worldwide, taking into account those articles where DNA sequencing was performed; and to analyse the density of each type of livestock that can act as intermediate host, and features of medical importance such as cyst organ location. METHODS: Literature search in numerous databases. We included only articles where samples were genotyped by sequencing since to date it is the most accurate method to unambiguously identify all E. granulosus s. l. genotypes. Also, we report new E. granulosus s. l. samples from Argentina and Uruguay analysed by sequencing of cox1 gene. RESULTS: In South America, five countries have cystic echinococcosis cases for which sequencing data are available: Argentina, Brazil, Chile, Peru and Uruguay, adding up 1534 cases. E. granulosus s. s. (G1) accounts for most of the global burden of human and livestock cases. Also, E. canadensis (G6) plays a significant role in humancystic echinococcosis. Likewise, worldwide analysis of human cases showed that 72.9% are caused by E. granulosus s. s. (G1) and 12.2% and 9.6% by E. canadensis G6 and G7, respectively. CONCLUSIONS:E. granulosus s. s. (G1) accounts for most of the global burden followed by E. canadensis (G6 and G7) in South America and worldwide. This information should be taken into account to suit local cystic echinococcosis control and prevention programmes according to each molecular epidemiological situation.
Authors: Ana Maite Folle; Eduardo S Kitano; Analía Lima; Magdalena Gil; Marcela Cucher; Gustavo Mourglia-Ettlin; Leo K Iwai; Mara Rosenzvit; Carlos Batthyány; Ana María Ferreira Journal: PLoS Negl Trop Dis Date: 2017-01-03
Authors: Giovanni Matera; Maria Teresa Loria; Cinzia Peronace; Tatiana Catanzariti; Pio Settembre; Aida Giancotti; Angelo G Lamberti; Giorgio S Barreca; Luisa Galati; Gessica Dodaro; Maria Mazzitelli; Alessio Strazzulla; Carlo Torti; Angela Quirino; Maria Carla Liberto; Alfredo Focà Journal: Mediators Inflamm Date: 2018-01-14 Impact factor: 4.711