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Literature DB >> 26609477

microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1).

Wei Dai¹, Hai-Li Huang², Min Hu¹, Si-Jie Wang², Hui-Juan He², Nian-Pin Chen¹, Ming-Yi Li¹.

Abstract

Our previous study indicates microRNA-506 (miR-506) is downregulated in hepatocellular carcinoma (HCC). In the current study, we investigate the effects of miR-506 on proliferation, migration and invasion in HCC. We report that enforced expression of miR-506 inhibits proliferation, migration and invasion in vitro, and suppresses tumor growth in vivo. Conversely, suppression of miR-506 exhibits promoting effects on proliferation, migration and invasion in vitro, and on tumor growth in vivo. In addition, miR-506 binds to the 3'UTR of F-spondin 1(SPON1), and enforced expression of miR-506 decreases accumulation of SPON1. Moreover, enforced expression of SPON1 and suppression of SPON1 alleviates effects of miR-506 mimics and inhibitors on proliferation, migration and invasion in vitro, respectively. In conclusion, microRNA-506 regulates proliferation, migration and invasion in HCC by targeting SPON1.

Entities: Disease Gene

Keywords: SPON1; hepatocellular carcinoma; microRNA-506; migration and invasion; proliferation

Year: 2015 PMID： 26609477 PMCID： PMC4633899

Source DB: PubMed Journal: Am J Cancer Res ISSN： 2156-6976 Impact factor: 6.166

23 in total

1. F-spondin promotes nerve precursor differentiation.

Authors: David Schubert; Avihu Klar; Minkyu Park; Richard Dargusch; Wolfgang H Fischer
Journal: J Neurochem Date: 2005-11-21 Impact factor: 5.372

2. F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension.

Authors: A Klar; M Baldassare; T M Jessell
Journal: Cell Date: 1992-04-03 Impact factor: 41.582

3. MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1.

Authors: Jun Deng; Wan Lei; Xiaojun Xiang; Ling Zhang; Feng Yu; Jun Chen; Miao Feng; Jianping Xiong
Journal: Tumour Biol Date: 2015-04-07

4. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer.

Authors: S-Y Wen; Y Lin; Y-Q Yu; S-J Cao; R Zhang; X-M Yang; J Li; Y-L Zhang; Y-H Wang; M-Z Ma; W-W Sun; X-L Lou; J-H Wang; Y-C Teng; Z-G Zhang
Journal: Oncogene Date: 2014-03-10 Impact factor: 9.867

5. MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells.

Authors: Jin Lu Tong; Chen Peng Zhang; Fang Nie; Xi Tao Xu; Ming Ming Zhu; Shu Dong Xiao; Zhi Hua Ran
Journal: FEBS Lett Date: 2011-10-22 Impact factor: 4.124

6. F-spondin inhibits differentiation of clastic precursors via lipoprotein receptor-related protein 8 (LRP8).

Authors: Hiroko Oka; Masae Kitagawa; Takashi Takata
Journal: J Periodontol Date: 2014-10-09 Impact factor: 6.993

7. The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.

Authors: Shotaro Sakimura; Keishi Sugimachi; Junji Kurashige; Masami Ueda; Hidenari Hirata; Sho Nambara; Hisateru Komatsu; Tomoko Saito; Yuki Takano; Ryutaro Uchi; Etsuko Sakimura; Yoshiaki Shinden; Tomohiro Iguchi; Hidetoshi Eguchi; Yugo Oba; Sumio Hoka; Koshi Mimori
Journal: Ann Surg Oncol Date: 2015-02-24 Impact factor: 5.344

8. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States.

Authors: Sean F Altekruse; S Jane Henley; James E Cucinelli; Katherine A McGlynn
Journal: Am J Gastroenterol Date: 2014-02-11 Impact factor: 10.864

9. miR-506 regulates epithelial mesenchymal transition in breast cancer cell lines.

Authors: Himanshu Arora; Rehana Qureshi; Woong-Yang Park
Journal: PLoS One Date: 2013-05-22 Impact factor: 3.240

10. Incidence and mortality of liver cancer in China, 2010.

Authors: Kuang-Rong Wei; Xia Yu; Rong-Shou Zheng; Xia-Biao Peng; Si-Wei Zhang; Ming-Fang Ji; Zhi-Heng Liang; Zhi-Xiong Ou; Wan-Qing Chen
Journal: Chin J Cancer Date: 2014-07-11

12 in total

1. MicroRNA-506 suppresses invasiveness and metastasis of human hepatocellular carcinoma cells by targeting IL8.

Authors: Zhuo Wang; Mahui Si; Ning Yang; Haibin Zhang; Yong Fu; Kai Yan; Yi Zong; Nan Zhu; Yongpeng Wei
Journal: Am J Cancer Res Date: 2018-08-01 Impact factor: 6.166

2. Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations.

Authors: Rozita Tamjidifar; Morteza Akbari; Saeed Tarzi; Mahsa Sadeghzadeh; Mahsa Abolghasemi; Elham Poursaei; Navid Shomali; Farshad Mahdavi
Journal: J Gastrointest Cancer Date: 2021-03

3. Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.

Authors: Shanqi Guo; Peiying Yang; Xingkang Jiang; Xiaojiang Li; Yuanyuan Wang; Xin Zhang; Binxu Sun; Yao Zhang; Yingjie Jia
Journal: Oncotarget Date: 2017-01-03

10. Identification of a Novel Oncogenic Fusion Gene SPON1-TRIM29 in Clinical Ovarian Cancer That Promotes Cell and Tumor Growth and Enhances Chemoresistance in A2780 Cells.

Authors: Saya Nagasawa; Kazuhiro Ikeda; Daisuke Shintani; Chiujung Yang; Satoru Takeda; Kosei Hasegawa; Kuniko Horie; Satoshi Inoue
Journal: Int J Mol Sci Date: 2022-01-08 Impact factor: 5.923