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Literature DB >> 26608890

The ELF Honest Data Broker: informatics enabling public-private collaboration in a precompetitive arena.

Guillaume Paillard¹, Philip Cochrane², Philip S Jones³, Willem P van Hoorn⁴, Andrei Caracoti¹, Herman van Vlijmen⁵, Andrew D Pannifer⁶.

Abstract

New precompetitive ways of working in the pharmaceutical industry are driving the development of new informatics systems to enable their execution and management. The European Lead Factory (ELF) is a precompetitive, 30-partner collaboration between academic groups, small-medium enterprises and pharmaceutical companies created to discover small molecule hits against novel biological targets. A unique HTS screening and triage workflow has been developed to balance the intellectual property and scientific requirements of all the partners. Here, we describe the ELF Honest Data Broker, a cloud-based informatics system providing the scientific triage tools, fine-grained permissions and management tools required to implement the workflow.

Mesh：

Substances：
Small Molecule Libraries

Year: 2015 PMID： 26608890 DOI： 10.1016/j.drudis.2015.11.005

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

Keyword Cloud
Cited

10 in total

Review 1. Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).

Authors: Sean Ekins; Anna Coulon Spektor; Alex M Clark; Krishna Dole; Barry A Bunin
Journal: Drug Discov Today Date: 2016-11-22 Impact factor: 7.851

2. Data Mining and Computational Modeling of High-Throughput Screening Datasets.

Authors: Sean Ekins; Alex M Clark; Krishna Dole; Kellan Gregory; Andrew M Mcnutt; Anna Coulon Spektor; Charlie Weatherall; Nadia K Litterman; Barry A Bunin
Journal: Methods Mol Biol Date: 2018

Review 3. The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.

Authors: Anna Karawajczyk; Kristina M Orrling; Jon S B de Vlieger; Ton Rijnders; Dimitrios Tzalis
Journal: Front Med (Lausanne) Date: 2017-01-19

4. Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective.

Authors: Julie M Rainard; George C Pandarakalam; Stuart P McElroy
Journal: SLAS Discov Date: 2018-03 Impact factor: 3.341

10. Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening.

Authors: Saman Honarnejad; Stan van Boeckel; Helma van den Hurk; Steven van Helden
Journal: SLAS Discov Date: 2020-07-31 Impact factor: 3.341

10 in total

The ELF Honest Data Broker: informatics enabling public-private collaboration in a precompetitive arena.

Review 1. Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).

2. Data Mining and Computational Modeling of High-Throughput Screening Datasets.

Review 3. The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.

4. Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective.

5. Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction.

6. De Novo Assembly of Highly Substituted Morpholines and Piperazines.

7. N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides.

8. Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations.

Review 9. Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.

10. Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening.