Małgorzata Knaś1, Mateusz Maciejczyk2, Katarzyna Sawicka3, Hady Razak Hady4, Marek Niczyporuk5, Jerzy R Ładny6, Jan Matczuk7, Danuta Waszkiel3, Małgorzata Żendzian-Piotrowska8, Anna Zalewska3. 1. Institute of Health Care Higher Vocational School, Suwalki, Poland. 2. Students' Scientific Group ''Stomatological Biochemistry'' at the Department of Conservative Dentistry, Medical University of Bialystok, Bialystok, Poland. 3. Department of Conservative Dentistry, Medical University Bialystok, Bialystok, Poland. 4. 1st Department of General Surgery and Endocrinology, Medical University Bialystok, Bialystok, Poland. 5. Research Laboratory of Esthetic Medicine, Medical University in Bialystok, Bialystok, Poland. 6. Department of Emergency Medicine and Disaster, Medical University Bialystok, Bialystok, Poland. 7. County Veterinary Inspection, Bialystok, Poland. 8. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
Abstract
OBJECTIVE: There is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva. MATERIALS AND METHODS: Salivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery. RESULTS: In both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obese patients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity. CONCLUSIONS: In morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment.
OBJECTIVE: There is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva. MATERIALS AND METHODS: Salivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery. RESULTS: In both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obesepatients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity. CONCLUSIONS: In morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obesepatients before and after treatment.
Authors: Tatyana M C P Farias; Belmiro C do E Vasconcelos; Juliana R SoutoMaior; Cleidiel A A Lemos; Sandra L D de Moraes; Eduardo P Pellizzer Journal: Obes Surg Date: 2019-05 Impact factor: 4.129
Authors: M Knaś; M Maciejczyk; I Daniszewska; A Klimiuk; J Matczuk; U Kołodziej; D Waszkiel; J R Ładny; M Żendzian-Piotrowska; A Zalewska Journal: J Diabetes Res Date: 2016-07-13 Impact factor: 4.011
Authors: Jan Matczuk; Anna Zalewska; Bartłomiej Łukaszuk; Małgorzata Knaś; Mateusz Maciejczyk; Marta Garbowska; Dominika M Ziembicka; Danuta Waszkiel; Adrian Chabowski; Małgorzata Żendzian-Piotrowska; Krzysztof Kurek Journal: J Diabetes Res Date: 2016-07-13 Impact factor: 4.011
Authors: Barbara Choromańska; Piotr Myśliwiec; Magdalena Łuba; Piotr Wojskowicz; Hanna Myśliwiec; Katarzyna Choromańska; Małgorzata Żendzian-Piotrowska; Jacek Dadan; Anna Zalewska; Mateusz Maciejczyk Journal: Antioxidants (Basel) Date: 2020-05-01
Authors: Magdalena Choromańska; Anna Klimiuk; Paula Kostecka-Sochoń; Karolina Wilczyńska; Mikołaj Kwiatkowski; Natalia Okuniewska; Napoleon Waszkiewicz; Anna Zalewska; Mateusz Maciejczyk Journal: Int J Mol Sci Date: 2017-10-20 Impact factor: 5.923
Authors: Piotr Żukowski; Mateusz Maciejczyk; Jan Matczuk; Krzysztof Kurek; Danuta Waszkiel; Małgorzata Żendzian-Piotrowska; Anna Zalewska Journal: Oxid Med Cell Longev Date: 2018-01-30 Impact factor: 6.543
Authors: Katarzyna Fejfer; Piotr Buczko; Marek Niczyporuk; Jerzy R Ładny; Hady R Hady; Małgorzata Knaś; Danuta Waszkiel; Anna Klimiuk; Anna Zalewska; Mateusz Maciejczyk Journal: Biomed Res Int Date: 2017-12-31 Impact factor: 3.411
Authors: Jan Borys; Mateusz Maciejczyk; Bożena Antonowicz; Adam Krętowski; Danuta Waszkiel; Piotr Bortnik; Katarzyna Czarniecka-Bargłowska; Magdalena Kocisz; Julita Szulimowska; Marek Czajkowski; Napoleon Waszkiewicz; Anna Zalewska Journal: Oxid Med Cell Longev Date: 2018-06-14 Impact factor: 6.543