Literature DB >> 26608807

Molecular diagnosis: Implications for ophthalmology.

James T Rosenbaum1, Cailin H Sibley2, Dongseok Choi3, Christina A Harrington4, Stephen R Planck5.   

Abstract

The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.
Copyright © 2015. Published by Elsevier Ltd.

Entities:  

Keywords:  Granulomatosis with polyangiitis; Molecular diagnosis; Nonspecific orbital inflammatory disease; Sarcoidosis; Thyroid eye disease; Transcriptomics

Mesh：

Year:  2015        PMID： 26608807      PMCID： PMC4912839          DOI： 10.1016/j.preteyeres.2015.11.001

Source DB:  PubMed          Journal:  Prog Retin Eye Res        ISSN： 1350-9462            Impact factor:   21.198


  62 in total

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Journal:  N Engl J Med       Date:  2012-08-09       Impact factor: 91.245

2.  Potential utility of rituximab for Graves' orbitopathy.

Authors:  Mario Salvi; Guia Vannucchi; Paolo Beck-Peccoz
Journal:  J Clin Endocrinol Metab       Date:  2013-09-05       Impact factor: 5.958

3.  Gene expression profiling of orbital adipose tissue from patients with Graves' ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital adipogenesis.

Authors:  Seema Kumar; Alexey Leontovich; Michael J Coenen; Rebecca S Bahn
Journal:  J Clin Endocrinol Metab       Date:  2005-05-10       Impact factor: 5.958

4.  Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Authors:  Aravind Subramanian; Pablo Tamayo; Vamsi K Mootha; Sayan Mukherjee; Benjamin L Ebert; Michael A Gillette; Amanda Paulovich; Scott L Pomeroy; Todd R Golub; Eric S Lander; Jill P Mesirov
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-30       Impact factor: 11.205

Review 5.  Microarray studies of gene expression in circulating leukocytes in kidney diseases.

Authors:  David Alcorta; Gloria Preston; William Munger; Pamela Sullivan; Jia Jin Yang; Iwao Waga; J Charles Jennette; Ronald Falk
Journal:  Exp Nephrol       Date:  2002

6.  Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.

Authors:  Emily C Baechler; Franak M Batliwalla; George Karypis; Patrick M Gaffney; Ward A Ortmann; Karl J Espe; Katherine B Shark; William J Grande; Karis M Hughes; Vivek Kapur; Peter K Gregersen; Timothy W Behrens
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-25       Impact factor: 11.205

7.  Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathy.

Authors:  Daniel G Ezra; Jonathan Krell; Geoffrey E Rose; Maryse Bailly; Justin Stebbing; Leandro Castellano
Journal:  J Clin Pathol       Date:  2012-05-03       Impact factor: 3.411

8.  Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.

Authors:  James C Lee; Paul A Lyons; Eoin F McKinney; John M Sowerby; Edward J Carr; Francesca Bredin; Hannah M Rickman; Huzefa Ratlamwala; Alexander Hatton; Tim F Rayner; Miles Parkes; Kenneth G C Smith
Journal:  J Clin Invest       Date:  2011-09-26       Impact factor: 14.808

9.  Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study.

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Journal:  Arthritis Rheum       Date:  2013-04

Review 10.  Targeted therapies for ER+/HER2- metastatic breast cancer.

Authors:  Mutsuko Yamamoto-Ibusuki; Monica Arnedos; Fabrice André
Journal:  BMC Med       Date:  2015-06-09       Impact factor: 8.775
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  4 in total

Review 1.  Ocular sarcoidosis: new diagnostic modalities and treatment.

Authors:  Sung J Yang; Sherveen Salek; James T Rosenbaum
Journal:  Curr Opin Pulm Med       Date:  2017-09       Impact factor: 3.155

Review 2.  The potential of tear proteomics for diagnosis and management of orbital inflammatory disorders including Graves' ophthalmopathy.

Authors:  Hadi Khazaei; Danesh Khazaei; Rohan Verma; John Ng; Phillip A Wilmarth; Larry L David; James T Rosenbaum
Journal:  Exp Eye Res       Date:  2021-11-03       Impact factor: 3.467

3.  Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland.

Authors:  James T Rosenbaum; Dongseok Choi; Christina A Harrington; David J Wilson; Hans E Grossniklaus; Cailin H Sibley; Sherveen S Salek; John D Ng; Roger A Dailey; Eric A Steele; Brent Hayek; Caroline M Craven; Deepak P Edward; Azza M Y Maktabi; Hailah Al Hussain; Valerie A White; Peter J Dolman; Craig N Czyz; Jill A Foster; Gerald J Harris; Youn-Shen Bee; David T Tse; Chrisfouad R Alabiad; Sander R Dubovy; Michael Kazim; Dinesh Selva; R Patrick Yeatts; Bobby S Korn; Don O Kikkawa; Rona Z Silkiss; Jennifer A Sivak-Callcott; Patrick Stauffer; Stephen R Planck
Journal:  JAMA Ophthalmol       Date:  2017-11-01       Impact factor: 7.389

4.  Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics.

Authors:  James T Rosenbaum; Christina A Harrington; Robert P Searles; Suzanne S Fei; Amr Zaki; Sruthi Arepalli; Michael A Paley; Lynn M Hassman; Albert T Vitale; Christopher D Conrady; Puthyda Keath; Claire Mitchell; Lindsey Watson; Stephen R Planck; Tammy M Martin; Dongseok Choi
Journal:  Am J Ophthalmol       Date:  2020-09-15       Impact factor: 5.258
  4 in total

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