Literature DB >> 26608553

Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53.

Seong-Hee Moon1, Youngeun Jung2, Seong Hwan Kim3, Ikyon Kim4.   

Abstract

Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anticancer activity; Diversity-oriented synthesis; Indolizine; p53; β-Catenin

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Year:  2015        PMID： 26608553     DOI： 10.1016/j.bmcl.2015.11.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model.

Authors:  DaWon Kim; Jeong Hwa Lee; Hye Yun Kim; Jisu Shin; Kyeonghwan Kim; Sejin Lee; Jinwoo Park; JinIkyon Kim; YoungSoo Kim
Journal:  PLoS One       Date:  2020-12-23       Impact factor: 3.240

2.  Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones.

Authors:  Ekaterina A Sokolova; Alexey A Festa; Karthikeyan Subramani; Victor B Rybakov; Alexey V Varlamov; Leonid G Voskressensky; Erik V Van der Eycken
Journal:  Molecules       Date:  2020-09-05       Impact factor: 4.411
  2 in total

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