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Literature DB >> 26608550

Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.

Arvind Kumar¹, Arem Qayum², Parduman Raj Sharma³, Shashank Kumar Singh⁴, Bhahwal Ali Shah⁵.

Abstract

A series of β-boswellic acid derivatives were synthesized and evaluated for anticancer activity. One of the lead analog 4f displayed significant anticancer activity against a panel of cancer cells as well as substantially inhibited colony formation in HCT-116 cells. Furthermore, 4f was found to be a potent inducer of apoptosis confirmed by loss of mitochondrial membrane potential, DAPI staining, Western blotting and ROS generation.

Entities: Chemical Disease

Keywords: Anticancer; Apoptosis; Triterpenoid; β-Boswellic acid

Mesh：

Substances：

Year: 2015 PMID： 26608550 DOI： 10.1016/j.bmcl.2015.11.027

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

3 in total

1. 2-Pyridin-4-yl-methylene-beta-boswellic Acid-A Potential Candidate for Targeting O⁶-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D-Microsatellite Stable, G12V-Microsatellite Instable Mutant Colon Cancer.

Authors: Arem Qayum; Jasvinder Singh; Arvind Kumar; Syed Mohmad Shah; Shubham Srivastava; Manoj Kushwaha; Asmita Magotra; Utpal Nandi; Ruchi Malik; Bhahwal Ali Shah; Shashank Kumar Singh
Journal: ACS Pharmacol Transl Sci Date: 2022-04-18

2. Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cells.

Authors: Arem Qayum; Asmita Magotra; Syed Mohmad Shah; Utpal Nandi; P R Sharma; Bhahwal Ali Shah; Shashank Kumar Singh
Journal: Heliyon Date: 2022-03-16

Review 3. Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies.

Authors: Niege A J C Furtado; Laetitia Pirson; Hélène Edelberg; Lisa M Miranda; Cristina Loira-Pastoriza; Véronique Preat; Yvan Larondelle; Christelle M André
Journal: Molecules Date: 2017-03-04 Impact factor: 4.411

3 in total

Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.

1. 2-Pyridin-4-yl-methylene-beta-boswellic Acid-A Potential Candidate for Targeting O6-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D-Microsatellite Stable, G12V-Microsatellite Instable Mutant Colon Cancer.

2. Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cells.

Review 3. Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies.

1. 2-Pyridin-4-yl-methylene-beta-boswellic Acid-A Potential Candidate for Targeting O⁶-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D-Microsatellite Stable, G12V-Microsatellite Instable Mutant Colon Cancer.