Literature DB >> 26608312

Structure of an HIV-2 gp120 in Complex with CD4.

Yunji W Davenport1, Anthony P West1, Pamela J Bjorkman2.   

Abstract

HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26608312      PMCID： PMC4733984          DOI： 10.1128/JVI.02678-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  47 in total

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Journal:  Front Microbiol       Date:  2022-03-24       Impact factor: 5.640
  6 in total

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