Susanna Leivonen1, Arja Voutilainen2, Roshan Chudal3, Auli Suominen3, Mika Gissler4, Andre Sourander5. 1. Department of Child Psychiatry, University of Turku, Turku, Finland; Child Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Electronic address: susanna.leivonen@utu.fi. 2. Child Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. 3. Department of Child Psychiatry, University of Turku, Turku, Finland. 4. National Institute of Health and Welfare (THL), Helsinki, Finland; Nordic School of Public Health, Gothenburg, Sweden. 5. Department of Child Psychiatry, University of Turku, Turku, Finland; Department of Child Psychiatry, Turku University Hospital, Turku, Finland; Regional Centre for Child and Youth Mental Health and Child Welfare, UiT The Arctic University of Norway, Tromsø, Norway.
Abstract
OBJECTIVE: To determine the relationships between parity, obstetric adversities, neonatal factors, and Tourette syndrome in a large nationwide cohort. STUDY DESIGN: This nationwide, register-based, nested case-control study identified all children diagnosed with Tourette syndrome born between 1991 and 2010 from the Finnish Hospital Discharge Register (n = 767). Each case was matched to 4 controls. Information on parity, obstetric, and neonatal factors was obtained from the Finnish Medical Birth Register. Conditional logistic regression was used to determine the relationship between parity, obstetric, and neonatal factors, and Tourette syndrome. RESULTS: Nulliparity was associated with increased odds for Tourette syndrome (OR 1.7, 95% CI 1.4-2.2), and 3 or more previous births was associated with decreased odds for Tourette syndrome (OR 0.5, 95% CI 0.3-0.9) compared with parity 1-2. Birth weight 4000-4499 g was associated with decreased odds for Tourette syndrome (OR 0.7, 95% CI 0.5-0.9). Low birth weight, gestational age, weight for gestational age, Apgar score at 1 minute, induced labor, birth type or presentation, neonatal treatment, or maternal blood pressure were not associated with Tourette syndrome. CONCLUSIONS: Increasing parity and high birth weight are associated with decreased odds for Tourette syndrome.
OBJECTIVE: To determine the relationships between parity, obstetric adversities, neonatal factors, and Tourette syndrome in a large nationwide cohort. STUDY DESIGN: This nationwide, register-based, nested case-control study identified all children diagnosed with Tourette syndrome born between 1991 and 2010 from the Finnish Hospital Discharge Register (n = 767). Each case was matched to 4 controls. Information on parity, obstetric, and neonatal factors was obtained from the Finnish Medical Birth Register. Conditional logistic regression was used to determine the relationship between parity, obstetric, and neonatal factors, and Tourette syndrome. RESULTS: Nulliparity was associated with increased odds for Tourette syndrome (OR 1.7, 95% CI 1.4-2.2), and 3 or more previous births was associated with decreased odds for Tourette syndrome (OR 0.5, 95% CI 0.3-0.9) compared with parity 1-2. Birth weight 4000-4499 g was associated with decreased odds for Tourette syndrome (OR 0.7, 95% CI 0.5-0.9). Low birth weight, gestational age, weight for gestational age, Apgar score at 1 minute, induced labor, birth type or presentation, neonatal treatment, or maternal blood pressure were not associated with Tourette syndrome. CONCLUSIONS: Increasing parity and high birth weight are associated with decreased odds for Tourette syndrome.
Authors: Alden Y Huang; Dongmei Yu; Lea K Davis; Jae Hoon Sul; Fotis Tsetsos; Vasily Ramensky; Ivette Zelaya; Eliana Marisa Ramos; Lisa Osiecki; Jason A Chen; Lauren M McGrath; Cornelia Illmann; Paul Sandor; Cathy L Barr; Marco Grados; Harvey S Singer; Markus M Nöthen; Johannes Hebebrand; Robert A King; Yves Dion; Guy Rouleau; Cathy L Budman; Christel Depienne; Yulia Worbe; Andreas Hartmann; Kirsten R Müller-Vahl; Manfred Stuhrmann; Harald Aschauer; Mara Stamenkovic; Monika Schloegelhofer; Anastasios Konstantinidis; Gholson J Lyon; William M McMahon; Csaba Barta; Zsanett Tarnok; Peter Nagy; James R Batterson; Renata Rizzo; Danielle C Cath; Tomasz Wolanczyk; Cheston Berlin; Irene A Malaty; Michael S Okun; Douglas W Woods; Elliott Rees; Carlos N Pato; Michele T Pato; James A Knowles; Danielle Posthuma; David L Pauls; Nancy J Cox; Benjamin M Neale; Nelson B Freimer; Peristera Paschou; Carol A Mathews; Jeremiah M Scharf; Giovanni Coppola Journal: Neuron Date: 2017-06-21 Impact factor: 17.173
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Authors: Mohamed Abdulkadir; Jay A Tischfield; Robert A King; Thomas V Fernandez; Lawrence W Brown; Keun-Ah Cheon; Barbara J Coffey; Sebastian F T M de Bruijn; Lonneke Elzerman; Blanca Garcia-Delgar; Donald L Gilbert; Dorothy E Grice; Julie Hagstrøm; Tammy Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Young Key Kim; Young-Shin Kim; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Andreas Lamerz; Bennett Leventhal; Andrea G Ludolph; Marcos Madruga-Garrido; Athanasios Maras; Marieke D Messchendorp; Pablo Mir; Astrid Morer; Alexander Münchau; Tara L Murphy; Thaïra J C Openneer; Kerstin J Plessen; Judith J G Rath; Veit Roessner; Odette Fründt; Eun-Young Shin; Deborah A Sival; Dong-Ho Song; Jungeun Song; Anne-Marie Stolte; Jennifer Tübing; Els van den Ban; Frank Visscher; Sina Wanderer; Martin Woods; Samuel H Zinner; Matthew W State; Gary A Heiman; Pieter J Hoekstra; Andrea Dietrich Journal: J Psychiatr Res Date: 2016-07-22 Impact factor: 4.791