Literature DB >> 26607212

Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity.

Xiaoyu Wang1, Caijun Sun2, Pingchao Li2, Tongjin Wu2, Hangyu Zhou3, Dong Yang4, Yichu Liu2, Xiuchang Ma2, Zhiyong Song3, Qinggong Nian4, Liqiang Feng2, Chengfeng Qin4, Ling Chen2,5, Ruikang Tang1,3,6.   

Abstract

Dual-functional biomineral-vaccine core-shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently masks the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti-Ad5 immunity, leading to boosted multifunctional antigen-specific cytokine-secreting T cell responses and presenting promising applications of vaccine-material hybrid for the rational design of vaccines.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  T cells; adenovirus; calcium phosphate; preexisting immunity; vaccine engineering

Year:  2015        PMID： 26607212     DOI： 10.1002/adma.201503740

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  7 in total

Review 1.  Regulations of organism by materials: a new understanding of biological inorganic chemistry.

Authors:  Jiake Lin; Xiaoyu Wang; Ruikang Tang
Journal:  J Biol Inorg Chem       Date:  2019-06-07       Impact factor: 3.358

2.  Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection.

Authors:  Xiaoyu Wang; Yong-Qiang Deng; Dong Yang; Yun Xiao; Hui Zhao; Qing-Gong Nian; Xurong Xu; Xiao-Feng Li; Ruikang Tang; Cheng-Feng Qin
Journal:  Chem Sci       Date:  2017-10-20       Impact factor: 9.825

3.  Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.

Authors:  Fengling Feng; Jin Zhao; Pingchao Li; Ruiting Li; Ling Chen; Caijun Sun
Journal:  Viruses       Date:  2019-02-13       Impact factor: 5.048

4.  Preparation and Characterization of Mg-Doped Calcium Phosphate-Coated Phycocyanin Nanoparticles for Improving the Thermal Stability of Phycocyanin.

Authors:  Qian Li; Ping Dong; Laihao Li
Journal:  Foods       Date:  2022-02-10

5.  Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.

Authors:  Johanna M Galloway; Laura Senior; Jordan M Fletcher; Joseph L Beesley; Lorna R Hodgson; Robert L Harniman; Judith M Mantell; Jennifer Coombs; Guto G Rhys; Wei-Feng Xue; Majid Mosayebi; Noah Linden; Tanniemola B Liverpool; Paul Curnow; Paul Verkade; Derek N Woolfson
Journal:  ACS Nano       Date:  2018-01-22       Impact factor: 15.881

6.  Bio-inspired vertebral design for scalable and flexible perovskite solar cells.

Authors:  Xiangchuan Meng; Zheren Cai; Yanyan Zhang; Xiaotian Hu; Zhi Xing; Zengqi Huang; Zhandong Huang; Yongjie Cui; Ting Hu; Meng Su; Xunfan Liao; Lin Zhang; Fuyi Wang; Yanlin Song; Yiwang Chen
Journal:  Nat Commun       Date:  2020-06-15       Impact factor: 14.919

Review 7.  Strategies to Develop a Mucosa-Targeting Vaccine against Emerging Infectious Diseases.

Authors:  Fengling Feng; Ziyu Wen; Jiaoshan Chen; Yue Yuan; Congcong Wang; Caijun Sun
Journal:  Viruses       Date:  2022-03-03       Impact factor: 5.048
  7 in total

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