| Literature DB >> 26607016 |
Xiaolei Hu1, Xiaowen Ma2, Xin Wang2, Xiuli Zhao2, Xuling Xu2, Hui Gong2, Fengling Chen3, Junjie Sun4.
Abstract
We report 12 cases of patients with type 2 diabetic receiving recombinant human insulin injection, who had uncontrolled hyperglycemia or frequent episodes of hypoglycemia, high levels of serum insulin and positive insulin antibodies. The clinical characteristics and insulin antibodies pharmacokinetics parameters were analyzed. After administration of glucocorticoids, changing insulin formulations or discontinuing the insulin and switching to oral antidiabetic agents, the level of insulin antibodies decreased and the plasma glucose restored. Thus, we recommend to identify the presence of high insulin antibodies in patients with type 2 diabetes who experience unexplained high plasma glucose or frequent reoccurrence of hypoglycemia.Entities:
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Year: 2015 PMID： 26607016 DOI： 10.1016/j.ando.2015.10.004
Source DB: PubMed Journal: Ann Endocrinol (Paris) ISSN： 0003-4266 Impact factor: 2.478