| Literature DB >> 26606905 |
An-Ning Yang1, Hui-Ping Zhang2, Yue Sun3, Xiao-Ling Yang3, Nan Wang1, Guangrong Zhu1, Hui Zhang4, Hua Xu3, Sheng-Chao Ma4, Yue Zhang5, Gui-Zhong Li3, Yue-Xia Jia1, Jun Cao1, Yi-Deng Jiang6.
Abstract
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy on fatty acid-binding protein 4 (FABP4), and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased FABP4 expression and decreased methylation. The FABP4 expression and DNA methylation was assessed in the aorta of ApoE(-/-) mice fed high-methionine diet for 20weeks. Over-expression of FABP4 enhanced accumulation of total cholesterol and cholesterol ester in foam cells. The up-regulation of DNA methyltransferase 1 (DNMT1) promoted the methylation process and decreased FABP4 expression. These data suggest that FABP4 plays a key role in Hcy-mediated disturbance of lipid metabolism and that DNMT1 may be a novel therapeutic target in Hcy-related atherosclerosis.Entities:
Keywords: Atherosclerosis; DNA methylation; Fatty acid-binding protein 4; Foam cell; Homocysteine
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Year: 2015 PMID： 26606905 DOI： 10.1016/j.febslet.2015.11.010
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124