Qiuhong Yang1, Maogang Gong2, Shuang Cai1, Ti Zhang1, Justin T Douglas3, Viktor Chikan4, Neal M Davies5, Phil Lee6,7, In-Young Choi6,8, Shenqiang Ren9, M Laird Forrest1. 1. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA. 2. Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA. 3. Nuclear Magnetic Resonance Laboratory, University of Kansas, Lawrence, KS 66045, USA. 4. Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA. 5. The Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3E OT5, Canada. 6. Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA. 7. Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. 8. Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA. 9. Department of Mechanical Engineering and Temple Material Institute, Temple University, Philadelphia, PA 19122, USA.
Abstract
BACKGROUND: A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging. METHODS & RESULTS: A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region. CONCLUSION: This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.
BACKGROUND: A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging. METHODS & RESULTS: A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region. CONCLUSION: This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.
Authors: Irene Tsiapa; Eleni K Efthimiadou; Eirini Fragogeorgi; George Loudos; Alexandra D Varvarigou; Penelope Bouziotis; George C Kordas; Dimitris Mihailidis; George C Nikiforidis; Stavros Xanthopoulos; Dimitrios Psimadas; Maria Paravatou-Petsotas; Lazaros Palamaris; John D Hazle; George C Kagadis Journal: J Colloid Interface Sci Date: 2014-08-01 Impact factor: 8.128