Literature DB >> 26604938

Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?

Laura Sartiani1, Valentina Spinelli1, Annunziatina Laurino1, Sabrina Blescia1, Laura Raimondi1, Elisabetta Cerbai1, Alessandro Mugelli1.   

Abstract

Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.

Entities:  

Keywords:  angiotensin; angiotensin receptors blockers; angiotensin-converting enzyme inhibitors; sarcopenia; skeletal muscle

Year:  2015        PMID： 26604938      PMCID： PMC4625769          DOI： 10.11138/ccmbm/2015.12.2.135

Source DB:  PubMed          Journal:  Clin Cases Miner Bone Metab        ISSN： 1724-8914


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