Literature DB >> 26604752

Review on lipegfilgrastim.

Maja Gasparic1, Sophie Leyman1.   

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Year:  2015        PMID: 26604752      PMCID: PMC4639557          DOI: 10.2147/IJN.S96413

Source DB:  PubMed          Journal:  Int J Nanomedicine        ISSN: 1176-9114


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Dear editor Having read the original Hoggatt et al article1 and the corrigendum published online on August 27, 2015,2 we do not consider the description of lipegfilgrastim to be entirely accurate, and we would therefore like to clarify what lipegfilgrastim actually is. The description of lipegfilgrastim used in the original article was a “long-acting biosimilar filgrastim”.1 This description was subsequently amended in the corrigendum to “lipegfilgrastim has an active substance that is similar to filgrastim, with similar pharmacokinetics, receptor binding affinity, safety and efficacy as pegfilgrastim”.2 It is true that lipegfilgrastim is not a long-acting biosimilar of filgrastim. It is not approved under the biosimilar classification by the European Medicines Agency, and has its own distinct Anatomical Therapeutic Chemical (ATC) code (ATC code L03AA14, lipegfilgrastim; ATC code L03AA02, filgrastim; ATC code L03AA13, pegfilgrastim).3 Further, we believe lipegfilgrastim would be more accurately described as “glycopegylated, long-acting form of recombinant human filgrastim”. Furthermore, the original article does not give the correct indications for either filgrastim or lipegfilgrastim (eg, pages 2,648 and 2,649).1 In August 2013, the European Medicines Agency (EMA) approved lipegfilgrastim to be used for reducing the duration of neutropenia and the incidence of febrile neutropenia in adult patients treated with cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukemia and myelodysplastic syndromes).4 Lipegfilgrastim is currently marketed throughout Europe with this indication.
  2 in total

Review 1.  Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia.

Authors:  Jonathan Hoggatt; Tiffany A Tate; Louis M Pelus
Journal:  Int J Nanomedicine       Date:  2015-04-01

2.  Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia [Corrigendum].

Authors: 
Journal:  Int J Nanomedicine       Date:  2015-08-27
  2 in total

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