Z Yan1, Y Liang2,3, J Shi1, C Cai4, H Jiang4, A Song2, C Qiu3. 1. Department of Neurology, Jining No. 1 People's Hospital, Shandong, China. 2. School of Public Health, Jining Medical University, Shandong, China. 3. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet - Stockholm University, Stockholm, Sweden. 4. Xing Long Zhuang Hospital, Shandong Yankuang Group, Shandong, China.
Abstract
BACKGROUND AND PURPOSE: The possible association between carotid stenosis and cognitive impairment in the Chinese population has been rarely investigated. The association between the severity of carotid stenosis and cognitive impairment amongst older Chinese people living in a rural area was assessed. METHODS: This cross-sectional study included 1375 participants (age ≥60 years) from the Confucius Hometown Aging Project in Shandong. In 2010-2011, data were collected through interviews and clinical examinations. Carotid stenosis was assessed using ultrasonography. Cognitive impairment was defined according to the education-specific cutoff scores of the Mini-Mental State Examination. Data were analyzed using multinomial logistic models. RESULTS: The overall prevalence was 7.0% for moderate carotid stenosis, 2.0% for severe stenosis and 6.0% for cognitive impairment. The multi-adjusted odds ratio of cognitive impairment was 1.43 (95% confidence interval 0.63-3.22) for moderate carotid stenosis and 3.75 (1.24-11.40) for severe carotid stenosis (P(trend) = 0.023). Similar results were obtained in people without a history of cerebrovascular disease. CONCLUSIONS: Severe carotid stenosis, even asymptomatic, is associated with cognitive impairment independent of atherosclerotic risk factors and disorders amongst older Chinese people.
BACKGROUND AND PURPOSE: The possible association between carotid stenosis and cognitive impairment in the Chinese population has been rarely investigated. The association between the severity of carotid stenosis and cognitive impairment amongst older Chinese people living in a rural area was assessed. METHODS: This cross-sectional study included 1375 participants (age ≥60 years) from the Confucius Hometown Aging Project in Shandong. In 2010-2011, data were collected through interviews and clinical examinations. Carotid stenosis was assessed using ultrasonography. Cognitive impairment was defined according to the education-specific cutoff scores of the Mini-Mental State Examination. Data were analyzed using multinomial logistic models. RESULTS: The overall prevalence was 7.0% for moderate carotid stenosis, 2.0% for severe stenosis and 6.0% for cognitive impairment. The multi-adjusted odds ratio of cognitive impairment was 1.43 (95% confidence interval 0.63-3.22) for moderate carotid stenosis and 3.75 (1.24-11.40) for severe carotid stenosis (P(trend) = 0.023). Similar results were obtained in people without a history of cerebrovascular disease. CONCLUSIONS: Severe carotid stenosis, even asymptomatic, is associated with cognitive impairment independent of atherosclerotic risk factors and disorders amongst older Chinese people.
Authors: Nevine El Nahas; Amr Zaki; Magd Zakaria; Azza Abd El Naser; Ahmed El Bassiony; Eman Abdeldayem; Hossam Shokri; Ahmed El Bokl Journal: Neurol Sci Date: 2022-10-19 Impact factor: 3.830