Zhuang-Yun Zhang1, Da-Peng Gao2, Jiao-Jiao Yang3, Xiao-ru Sun2, Hui Zhang2, Jian Hu1, Zhi-Yong Fang2, Jian-Jun Yang3, Mu-Huo Ji4. 1. Department of Anesthesiology, People's Hospital of Lishui County, Nanjing 211200, China. 2. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. 3. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China; Jiangsu Province Key Laboratory of Anaesthesiology, Xuzhou Medical College, Xuzhou, China; Jiangsu Province Key Laboratory of Anaesthesia and Analgesia Application Technology, Xuzhou, China. 4. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. Electronic address: jimuhuo2009@sina.com.
Abstract
PURPOSE: The purpose of the present study was to test whether older red blood cells (RBCs) transfusion results in an increased risk of postoperative delirium (POD) and various in-hospital postoperative complications in elderly patients undergoing hip fracture surgery. MATERIALS AND METHODS: Patients (≥65 years) who underwent hip fracture surgery were enrolled, 179 patients were divided into two groups according to the storage time of the RBCs. The shorter storage time of RBCs transfusion group comprised patients who received RBCs ≤14 days old and the longer storage time of RBCs transfusion group comprised patients who received RBCs >14 days old. The blood samples were collected before anaesthesia induction, 4 and 24 h after RBCs transfusion for the determination of proinflammatory mediators, malondialdehyde, and superoxide dismutase activity. RESULTS: There was no difference in the baseline characteristics, the incidence of POD, and the in-hospital postoperative complications between the shorter storage time of RBCs transfusion group and the longer storage time of RBCs transfusion groups (P>0.05). Compared with the shorter storage time of RBCs transfusion group, the longer storage time of RBCs transfusion caused significantly longer duration of POD (P<0.05). There were significantly increased plasma levels of IL-8 and malondialdehyde at 24 h and IL-1β at 4 h after RBCs transfusion in the POD group compared with the non-POD group (P<0.05). CONCLUSION: Transfusion of the longer storage RBCs is not associated with a higher incidence of POD or in-hospital postoperative complications, but with longer duration of POD in elderly patients undergoing hip fracture surgery.
PURPOSE: The purpose of the present study was to test whether older red blood cells (RBCs) transfusion results in an increased risk of postoperative delirium (POD) and various in-hospital postoperative complications in elderly patients undergoing hip fracture surgery. MATERIALS AND METHODS:Patients (≥65 years) who underwent hip fracture surgery were enrolled, 179 patients were divided into two groups according to the storage time of the RBCs. The shorter storage time of RBCs transfusion group comprised patients who received RBCs ≤14 days old and the longer storage time of RBCs transfusion group comprised patients who received RBCs >14 days old. The blood samples were collected before anaesthesia induction, 4 and 24 h after RBCs transfusion for the determination of proinflammatory mediators, malondialdehyde, and superoxide dismutase activity. RESULTS: There was no difference in the baseline characteristics, the incidence of POD, and the in-hospital postoperative complications between the shorter storage time of RBCs transfusion group and the longer storage time of RBCs transfusion groups (P>0.05). Compared with the shorter storage time of RBCs transfusion group, the longer storage time of RBCs transfusion caused significantly longer duration of POD (P<0.05). There were significantly increased plasma levels of IL-8 and malondialdehyde at 24 h and IL-1β at 4 h after RBCs transfusion in the POD group compared with the non-POD group (P<0.05). CONCLUSION: Transfusion of the longer storage RBCs is not associated with a higher incidence of POD or in-hospital postoperative complications, but with longer duration of POD in elderly patients undergoing hip fracture surgery.
Authors: Chani Traube; Marisa Tucci; Marianne E Nellis; K Leslie Avery; Patrick S McQuillen; Julie C Fitzgerald; Jennifer A Muszynski; Jill M Cholette; Adam J Schwarz; Erika L Stalets; Maureen A Quaid; Sheila J Hanson; Jacques Lacroix; Ron W Reeder; Philip C Spinella Journal: Crit Care Med Date: 2022-02-01 Impact factor: 7.598
Authors: Jacob Raphael; Nadia B Hensley; Jonathan Chow; K Gage Parr; John S McNeil; Steven B Porter; Monica Taneja; Kenichi Tanaka; Michael Mazzeffi Journal: Anesthesiol Res Pract Date: 2021-11-22