Literature DB >> 26603479

Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery.

Yong Wang1, Hong Xiao1, Jing Fang2, Xingsu Yu2, Zhenwei Su1, Du Cheng1, Xintao Shuai3.   

Abstract

A novel siRNA delivery system based on a triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex, having high delivery efficiency not dependent on surface charge reversion in response to the pH value of tumor tissue, was used for target gene silencing in cancer therapy.

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Year:  2016        PMID： 26603479     DOI： 10.1039/c5cc09181k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Dual-function hybrid nanoparticles with gene silencing and anti-inflammatory effects.

Authors:  Oksana Fihurka; Vasyl Sava; Juan Sanchez-Ramos
Journal:  Nanomedicine (Lond)       Date:  2022-04-04       Impact factor: 6.096

2.  Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

Authors:  Sheng Wang; Peng Huang; Xiaoyuan Chen
Journal:  Adv Mater       Date:  2016-06-03       Impact factor: 30.849

3.  Reduction and pH dual-sensitive nanovesicles co-delivering doxorubicin and gefitinib for effective tumor therapy.

Authors:  Yangui Chen; Xiaoxia Li; Hong Xiao; Jinpeng Xiao; Bo Li; Xiaoyan Chen; Yong Wang; Du Cheng; Xintao Shuai
Journal:  RSC Adv       Date:  2018-01-09       Impact factor: 4.036

4.  Preliminary Study of MR and Fluorescence Dual-mode Imaging: Combined Macrophage-Targeted and Superparamagnetic Polymeric Micelles.

Authors:  Wen-Juan Li; Yong Wang; Yulin Liu; Teng Wu; Wen-Li Cai; Xin-Tao Shuai; Guo-Bin Hong
Journal:  Int J Med Sci       Date:  2018-01-01       Impact factor: 3.738
  4 in total

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