| Literature DB >> 26603234 |
Fernanda S Nascimento1, Lisandra A Suzuki1, Nilson Branco2, Regina M B Franco2, Paula D Andrade3, Sandra C B Costa3, Marcelo N Pedro3, Cláudio L Rossi1.
Abstract
Cerebral toxoplasmosis can be highly debilitating and occasionally fatal in persons with immune system deficiencies. In this study, we evaluated the Toxoplasma gondii-specific IgG subclass antibody response in 19 cerebrospinal fluid (CSF) samples from patients with cerebral toxoplasmosis who had a positive IgG anti-T. gondii ELISA standardized with a cyst antigen preparation. There were no significant differences between the rates of positivity and the antibody concentrations (arithmetic means of the ELISA absorbances, MEA) for IgG1 and IgG2, but the rates of positivity and MEA values for these two IgG subclasses were significantly higher than those for IgG3 and IgG4. The marked IgG2 response in CSF from patients with cerebral toxoplasmosis merits further investigation.Entities:
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Year: 2015 PMID： 26603234 PMCID： PMC4660456 DOI： 10.1590/S0036-46652015000500013
Source DB: PubMed Journal: Rev Inst Med Trop Sao Paulo ISSN： 0036-4665 Impact factor: 1.846