Dabo Liu1, Zhenyun Huang2, Yaping Huang2, Xinhua Yi2, Xi Chen2. 1. Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China. Electronic address: gzdaboliu@126.com. 2. Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China.
Abstract
OBJECTIVES: To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with upper airway inflammatory disease. METHODS: Fifteen healthy children, 30 with allergic rhinitis (AR), 10 with non-allergic rhinitis (NAR), and 30 with sleep disordered breathing (SDB) were enrolled. The FeNO and nNO concentrations were measured non-invasively using a NIOX MINO system. RESULTS: Both nNO and FeNO were significantly higher in children with AR than in healthy children (P=0.000 and P=0.000, respectively). Compared to healthy children, nNO was also significant higher in children with NAR (P=0.011) or SDB (P=0.027). In contrast, FeNO did not differ from controls in children with NAR or SDB. CONCLUSIONS: Our data suggest that nNO has potential value for diagnosing upper airway inflammation. Moreover, elevated FeNO distinguishes allergic from non-allergic rhinitis.
OBJECTIVES: To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with upper airway inflammatory disease. METHODS: Fifteen healthy children, 30 with allergic rhinitis (AR), 10 with non-allergic rhinitis (NAR), and 30 with sleep disordered breathing (SDB) were enrolled. The FeNO and nNO concentrations were measured non-invasively using a NIOX MINO system. RESULTS: Both nNO and FeNO were significantly higher in children with AR than in healthy children (P=0.000 and P=0.000, respectively). Compared to healthy children, nNO was also significant higher in children with NAR (P=0.011) or SDB (P=0.027). In contrast, FeNO did not differ from controls in children with NAR or SDB. CONCLUSIONS: Our data suggest that nNO has potential value for diagnosing upper airway inflammation. Moreover, elevated FeNO distinguishes allergic from non-allergic rhinitis.
Authors: Giulia Brindisi; Valentina De Vittori; Rosalba De Nola; Antonio Di Mauro; Giovanna De Castro; Maria Elisabetta Baldassarre; Ettore Cicinelli; Bianca Cinicola; Marzia Duse; Anna Maria Zicari Journal: J Asthma Allergy Date: 2021-03-25