Sandrine Andrieu1, Nicola Coley2, Yves Rolland3, Christelle Cantet3, Catherine Arnaud2, Sophie Guyonnet3, Fati Nourhashemi3, Alain Grand2, Bruno Vellas3. 1. Inserm-Toulouse University UMR1027, Toulouse, France; CHU Toulouse, Department of Epidemiology and Public Health, Toulouse, France. Electronic address: sandrine.andrieu@univ-tlse3.fr. 2. Inserm-Toulouse University UMR1027, Toulouse, France; CHU Toulouse, Department of Epidemiology and Public Health, Toulouse, France. 3. Inserm-Toulouse University UMR1027, Toulouse, France; Gerontopole, CHU Toulouse, Department of Geriatric Medicine, Toulouse, France.
Abstract
INTRODUCTION: Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. METHODS: Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. RESULTS: Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. DISCUSSION: It is important to assess both self and caregiver ratings when assessing patient QOL.
INTRODUCTION: Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. METHODS:Patient QOL was evaluated in a cohort of 574 ADpatients with the QOL-AD scale over 2 years. RESULTS: Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. DISCUSSION: It is important to assess both self and caregiver ratings when assessing patient QOL.
Authors: Linda Clare; Laura D Gamble; Anthony Martyr; Serena Sabatini; Sharon M Nelis; Catherine Quinn; Claire Pentecost; Christina Victor; Roy W Jones; Ian R Jones; Martin Knapp; Rachael Litherland; Robin G Morris; Jennifer M Rusted; Jeanette M Thom; Rachel Collins; Catherine Henderson; Fiona E Matthews Journal: J Gerontol B Psychol Sci Soc Sci Date: 2022-06-01 Impact factor: 4.942
Authors: Kristin Kahle-Wrobleski; Wenyu Ye; David Henley; Ann Marie Hake; Eric Siemers; Yun-Fei Chen; Hong Liu-Seifert Journal: Alzheimers Dement (Amst) Date: 2016-12-13
Authors: Youssef H El-Hayek; Ryan E Wiley; Charles P Khoury; Ritesh P Daya; Clive Ballard; Alison R Evans; Michael Karran; José Luis Molinuevo; Matthew Norton; Alireza Atri Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Anthony Martyr; Sharon M Nelis; Catherine Quinn; Jennifer M Rusted; Robin G Morris; Linda Clare Journal: Int J Geriatr Psychiatry Date: 2019-05-20 Impact factor: 3.485