Literature DB >> 26601969

Unique Medicinal Properties of Withania somnifera: Phytochemical Constituents and Protein Component.

Parvaiz A Dar, Laishram R Singh, Mohammad A Kamal, Tanveer A Dar1.   

Abstract

Withania somnifera is an important medicinal herb that has been widely used for the treatment of different clinical conditions. The overall medicinal properties of Withania somnifera make it a viable therapeutic agent for addressing anxiety, cancer, microbial infection, immunomodulation, and neurodegenerative disorders. Biochemical constituents of Withania somnifera like withanolideA, withanolide D, withaferin A and withaniamides play an important role in its pharmacological properties. Proteins like Withania somnifera glycoprotein and withania lectin like-protein possess potent therapeutic properties like antimicrobial, anti-snake venom poison and antimicrobial. In this review, we have tried to present different pharmacological properties associated with different extract preparations, phytochemical constituents and protein component of Withania somnifera. Future insights in this direction have also been highlighted.

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Year:  2016        PMID： 26601969     DOI： 10.2174/1381612822666151125001751

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  11 in total

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Authors:  Mohammad A Kamal; Nigel H Greig
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3.  Editorial: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development.

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Journal:  PLoS One       Date:  2016-12-09       Impact factor: 3.240

5.  Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice.

Authors:  Xianlei Yan; Guangxiang Huang; Quan Liu; Jiemin Zheng; Hongmou Chen; Qidan Huang; Jiakang Chen; Heqing Huang
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

6.  Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice.

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Journal:  Behav Brain Funct       Date:  2019-05-07       Impact factor: 3.759

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8.  Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.

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Journal:  PLoS One       Date:  2021-05-13       Impact factor: 3.240

9.  Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats.

Authors:  Kazim Sahin; Cemal Orhan; Fatih Akdemir; Mehmet Tuzcu; Hasan Gencoglu; Nurhan Sahin; Gaffari Turk; Ismet Yilmaz; Ibrahim H Ozercan; Vijaya Juturu
Journal:  BMC Complement Altern Med       Date:  2016-08-26       Impact factor: 3.659

10.  Lectins from Synadenium carinatum (ScLL) and Artocarpus heterophyllus (ArtinM) Are Able to Induce Beneficial Immunomodulatory Effects in a Murine Model for Treatment of Toxoplasma gondii Infection.

Authors:  Eliézer L P Ramos; Silas S Santana; Murilo V Silva; Fernanda M Santiago; Tiago W P Mineo; José R Mineo
Journal:  Front Cell Infect Microbiol       Date:  2016-11-25       Impact factor: 5.293
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