Garcilaso Riesco-Eizaguirre1, Juan Carlos Galofré2, Enrique Grande3, Carles Zafón Llopis4, Teresa Ramón y Cajal Asensio5, Elena Navarro González6, Paula Jiménez-Fonseca7, Javier Santamaría Sandi8, José Manuel Gómez Sáez9, Jaume Capdevila10. 1. Department of Endocrinology and Nutrition, Hospital Universitario de Móstoles, Madrid, Spain. Electronic address: griesco@iib.uam.es. 2. Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. 3. Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain. 4. Department of Endocrinology and Nutrition, Vall d'Hebron University Hospital, Barcelona, Spain. 5. Medical Oncology Department, Santa Creu i Sant Pau University Hospital, Barcelona, Spain. 6. Department of Endocrinology and Nutrition, Vírgen del Rocío University Hospital, Sevilla, Spain. 7. Medical Oncology Department, Central de Asturias University Hospital, Oviedo, Asturias, Spain. 8. Department of Endocrinology and Nutrition, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain. 9. CIBERDEM Service of Endocrinology and Nutrition, Hospital Universitario de Bellvitge, Barcelona, Spain. 10. Medical Oncology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Abstract
BACKGROUND: Approximately one third of the patients with differentiated thyroid cancer (DTC) who develop structurally-evident metastatic disease are refractory to radioactive iodine (RAI). Most deaths from thyroid cancer occur in these patients. The main objective of this consensus is to address the most controversial aspects of management of these patients. METHODS: On behalf of the Spanish Society of Endocrinology & Nutrition (SEEN) and the Spanish Group for Orphan and Infrequent Tumors (GETHI), the Spanish Task Force for Thyroid Cancer, consisting of endocrinologists and oncologists, reviewed the relevant literature and prepared a series of clinically relevant questions related to management of advanced RAI-refractory DTC. RESULTS: Ten clinically relevant questions were identified by the task force. In answering to these 10 questions, the task force included recommendations regarding the best definition of refractoriness; the best therapeutic options including watchful waiting, local therapies, and systemic therapy (e.g. kinase inhibitors), when sodium iodide symporter (NIS) restoration may be expected; and how recent advances in molecular biology have increased our understanding of the disease. CONCLUSIONS: In response to our appointment as a task force by the SEEN and GHETI, we developed a consensus to help in clinical management of patients with advanced RAI-refractory DTC. We think that this consensus will provide helpful and current recommendations that will help patients with this disorder to get optimal medical care.
BACKGROUND: Approximately one third of the patients with differentiated thyroid cancer (DTC) who develop structurally-evident metastatic disease are refractory to radioactive iodine (RAI). Most deaths from thyroid cancer occur in these patients. The main objective of this consensus is to address the most controversial aspects of management of these patients. METHODS: On behalf of the Spanish Society of Endocrinology & Nutrition (SEEN) and the Spanish Group for Orphan and Infrequent Tumors (GETHI), the Spanish Task Force for Thyroid Cancer, consisting of endocrinologists and oncologists, reviewed the relevant literature and prepared a series of clinically relevant questions related to management of advanced RAI-refractory DTC. RESULTS: Ten clinically relevant questions were identified by the task force. In answering to these 10 questions, the task force included recommendations regarding the best definition of refractoriness; the best therapeutic options including watchful waiting, local therapies, and systemic therapy (e.g. kinase inhibitors), when sodium iodide symporter (NIS) restoration may be expected; and how recent advances in molecular biology have increased our understanding of the disease. CONCLUSIONS: In response to our appointment as a task force by the SEEN and GHETI, we developed a consensus to help in clinical management of patients with advanced RAI-refractory DTC. We think that this consensus will provide helpful and current recommendations that will help patients with this disorder to get optimal medical care.
Authors: M Molina-Vega; J García-Alemán; A Sebastián-Ochoa; I Mancha-Doblas; J M Trigo-Pérez; F Tinahones-Madueño Journal: Endocrine Date: 2017-12-23 Impact factor: 3.633
Authors: María San Román Gil; Javier Pozas; Javier Molina-Cerrillo; Joaquín Gómez; Héctor Pian; Miguel Pozas; Alfredo Carrato; Enrique Grande; Teresa Alonso-Gordoa Journal: Int J Mol Sci Date: 2020-07-13 Impact factor: 5.923