Literature DB >> 2660142

Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

M van de Rijn1, S Heimfeld, G J Spangrude, I L Weissman.   

Abstract

Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.

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Year:  1989        PMID： 2660142      PMCID： PMC287325          DOI： 10.1073/pnas.86.12.4634

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets.

Authors:  G J Spangrude; Y Aihara; I L Weissman; J Klein
Journal:  J Immunol       Date:  1988-12-01       Impact factor: 5.422

2.  A cell-surface molecule involved in organ-specific homing of lymphocytes.

Authors:  W M Gallatin; I L Weissman; E C Butcher
Journal:  Nature       Date:  1983 Jul 7-13       Impact factor: 49.962

3.  Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.

Authors:  H Auchincloss; K Ozato; D H Sachs
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

4.  Monoclonal anti-idiotype antibodies against the murine B cell lymphoma 38C13: characterization and use as probes for the biology of the tumor in vivo and in vitro.

Authors:  D G Maloney; M S Kaminski; D Burowski; J Haimovich; R Levy
Journal:  Hybridoma       Date:  1985

5.  Studies of the mouse Ly-6 alloantigen system. I. Serological characterization of mouse Ly-6 alloantigen by monoclonal antibodies.

Authors:  S Kimura; N Tada; E Nakayama; U Hämmerling
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

6.  Studies of the mouse Ly-6 alloantigen system. II. Complexities of the Ly-6 region.

Authors:  S Kimura; N Tada; Y Liu-Lam; U Hämmerling
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

7.  Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1.

Authors:  H Reiser; H Oettgen; E T Yeh; C Terhorst; M G Low; B Benacerraf; K L Rock
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

8.  Isolation of a murine Ly-6 cDNA reveals a new multigene family.

Authors:  K P LeClair; R G Palfree; P M Flood; U Hammerling; A Bothwell
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598

9.  T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

Authors:  K C Gunter; T R Malek; E M Shevach
Journal:  J Exp Med       Date:  1984-03-01       Impact factor: 14.307

10.  Isolation of murine pluripotent hemopoietic stem cells.

Authors:  J W Visser; J G Bauman; A H Mulder; J F Eliason; A M de Leeuw
Journal:  J Exp Med       Date:  1984-06-01       Impact factor: 14.307
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  73 in total

1.  Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.

Authors:  Regis Doyonnas; Mark A LaBarge; Alessandra Sacco; Carol Charlton; Helen M Blau
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-07       Impact factor: 11.205

2.  Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.

Authors:  Hongyan Yuan; Geeta Upadhyay; Yuzhi Yin; Levy Kopelovich; Robert I Glazer
Journal:  Cancer Prev Res (Phila)       Date:  2011-09-28

3.  Clonal analysis of hematopoietic stem-cell differentiation in vivo.

Authors:  L G Smith; I L Weissman; S Heimfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

4.  Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.

Authors:  Timothy Dahlem; Scott Cho; Gerald J Spangrude; Janis J Weis; John H Weis
Journal:  Eur J Immunol       Date:  2012-04       Impact factor: 5.532

5.  Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes.

Authors:  Irina Kirillova; Emanuela Gussoni; David J Goldhamer; Zipora Yablonka-Reuveni
Journal:  Dev Biol       Date:  2007-09-07       Impact factor: 3.582

Review 6.  The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.

Authors:  Irving L Weissman; Judith A Shizuru
Journal:  Blood       Date:  2008-11-01       Impact factor: 22.113

Review 7.  Mammary gland stem cells: more puzzles than explanations.

Authors:  Suneesh Kaimala; Swathi Bisana; Satish Kumar
Journal:  J Biosci       Date:  2012-06       Impact factor: 1.826

8.  Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.

Authors:  Jichun Chen; Felicia M Ellison; Keyvan Keyvanfar; Stephanie O Omokaro; Marie J Desierto; Michael A Eckhaus; Neal S Young
Journal:  Exp Hematol       Date:  2008-06-17       Impact factor: 3.084

9.  Epimorphic regeneration approach to tissue replacement in adult mammals.

Authors:  Vineet Agrawal; Scott A Johnson; Janet Reing; Li Zhang; Stephen Tottey; Gang Wang; Karen K Hirschi; Susan Braunhut; Lorraine J Gudas; Stephen F Badylak
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-04       Impact factor: 11.205

10.  Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease.

Authors:  Anna Rita Migliaccio; Fabrizio Martelli; Maria Verrucci; Giovanni Migliaccio; Alessandro Maria Vannucchi; Hongyu Ni; Mingjiang Xu; Yi Jiang; Betty Nakamoto; Thalia Papayannopoulou; Ronald Hoffman
Journal:  Exp Hematol       Date:  2008-02       Impact factor: 3.084
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