Till Ittermann1, Roberto Lorbeer2, Daniel Tiller3, Ina Lehmphul4, Alexander Kluttig3, Stephan B Felix5, Karl Werdan6, Karin Halina Greiser7, Josef Köhrle4, Henry Völzke1, Marcus Dörr5. 1. Institute for Community Medicine, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany ; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 2. Institute for Community Medicine, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany. 3. Institute of Medical Epidemiology, Biostatistics and Informatics, Halle (Saale), Germany. 4. Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany. 5. Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany ; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 6. Department of Medicine III, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. 7. German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany.
Abstract
BACKGROUND: There is only limited data on the potential association between thyroid dysfunction and peripheral arterial disease (PAD). OBJECTIVE: The aim of our study was to investigate the potential association of thyroid function, as defined by serum concentrations of the clinically used primary thyroid function marker thyrotropin [i.e. thyroid-stimulating hormone (TSH)] and 3,5-diiodothyronine (3,5-T2), with the ankle-brachial index (ABI) as a marker of PAD. METHODS: We used data from 5,818 individuals from three cross-sectional population-based studies conducted in Northeast (SHIP-2 and SHIP-TREND) and Central Germany (CARLA). Measurement of serum TSH concentrations was conducted in one central laboratory for all three studies. In a randomly selected subpopulation of 750 individuals of SHIP-TREND, serum 3,5-T2 concentrations were measured with a recently developed immunoassay. ABI was measured either by a hand-held Doppler ultrasound using the Huntleigh Dopplex D900 or palpatorily by the OMRON HEM-705CP device. RESULTS: Serum TSH concentrations were not significantly associated with ABI values in any of the three studies. Likewise, groups of individuals with a TSH <0.3 mIU/l or with a TSH ≥3.0 mIU/l had no significantly different ABI values in comparison with individuals with a TSH in the reference range. Analyses regarding TSH within the reference range or serum 3,5-T2 concentrations did not reveal consistent significant associations with the ABI. No sex-specific associations were detected. CONCLUSIONS: The results of our study do not substantiate evidence for an association between thyroid function and PAD, but further studies are needed to investigate the associations of overt forms of thyroid dysfunction with PAD.
BACKGROUND: There is only limited data on the potential association between thyroid dysfunction and peripheral arterial disease (PAD). OBJECTIVE: The aim of our study was to investigate the potential association of thyroid function, as defined by serum concentrations of the clinically used primary thyroid function marker thyrotropin [i.e. thyroid-stimulating hormone (TSH)] and 3,5-diiodothyronine (3,5-T2), with the ankle-brachial index (ABI) as a marker of PAD. METHODS: We used data from 5,818 individuals from three cross-sectional population-based studies conducted in Northeast (SHIP-2 and SHIP-TREND) and Central Germany (CARLA). Measurement of serum TSH concentrations was conducted in one central laboratory for all three studies. In a randomly selected subpopulation of 750 individuals of SHIP-TREND, serum 3,5-T2 concentrations were measured with a recently developed immunoassay. ABI was measured either by a hand-held Doppler ultrasound using the Huntleigh Dopplex D900 or palpatorily by the OMRON HEM-705CP device. RESULTS: Serum TSH concentrations were not significantly associated with ABI values in any of the three studies. Likewise, groups of individuals with a TSH <0.3 mIU/l or with a TSH ≥3.0 mIU/l had no significantly different ABI values in comparison with individuals with a TSH in the reference range. Analyses regarding TSH within the reference range or serum 3,5-T2 concentrations did not reveal consistent significant associations with the ABI. No sex-specific associations were detected. CONCLUSIONS: The results of our study do not substantiate evidence for an association between thyroid function and PAD, but further studies are needed to investigate the associations of overt forms of thyroid dysfunction with PAD.
Authors: Henry Völzke; Dietrich Alte; Carsten Oliver Schmidt; Dörte Radke; Roberto Lorbeer; Nele Friedrich; Nicole Aumann; Katharina Lau; Michael Piontek; Gabriele Born; Christoph Havemann; Till Ittermann; Sabine Schipf; Robin Haring; Sebastian E Baumeister; Henri Wallaschofski; Matthias Nauck; Stephanie Frick; Andreas Arnold; Michael Jünger; Julia Mayerle; Matthias Kraft; Markus M Lerch; Marcus Dörr; Thorsten Reffelmann; Klaus Empen; Stephan B Felix; Anne Obst; Beate Koch; Sven Gläser; Ralf Ewert; Ingo Fietze; Thomas Penzel; Martina Dören; Wolfgang Rathmann; Johannes Haerting; Mario Hannemann; Jürgen Röpcke; Ulf Schminke; Clemens Jürgens; Frank Tost; Rainer Rettig; Jan A Kors; Saskia Ungerer; Katrin Hegenscheid; Jens-Peter Kühn; Julia Kühn; Norbert Hosten; Ralf Puls; Jörg Henke; Oliver Gloger; Alexander Teumer; Georg Homuth; Uwe Völker; Christian Schwahn; Birte Holtfreter; Ines Polzer; Thomas Kohlmann; Hans J Grabe; Dieter Rosskopf; Heyo K Kroemer; Thomas Kocher; Reiner Biffar; Ulrich John; Wolfgang Hoffmann Journal: Int J Epidemiol Date: 2010-02-18 Impact factor: 7.196
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Authors: Lamiaa Hassan; Ljupcho Efremov; Anne Großkopf; Alexander Kluttig; Rafael Mikolajczyk; Nadja Kartschmit; Daniel Medenwald; Artjom Schott; Andrea Schmidt-Pokrzywniak; Maria E Lacruz; Daniel Tiller; Frank Bernhard Kraus; Karin H Greiser; Johannes Haerting; Karl Werdan; Daniel Sedding; Andreas Simm; Sebastian Nuding Journal: Eur J Epidemiol Date: 2022-01-03 Impact factor: 8.082