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Literature DB >> 2660074

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

Abstract

Our recent studies suggested that the ret proto-oncogene protein is a cell surface receptor with a tyrosine kinase domain. However, the sequence of its cDNA lacked an amino-terminal signal sequence characteristic of membrane proteins. In the present study we have isolated and sequenced an additional cDNA clone. The nucleotide sequence of the cDNA obtained indicated that the 5' terminal 330 nucleotides differs from the published sequence of the ret proto-oncogene. In addition, the sequence contains an open reading frame with an amino-terminal signal sequence.

Entities: Gene Mutation

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Year: 1989 PMID： 2660074

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

30 in total

1. A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.

Authors: S Bolk; A Pelet; R M Hofstra; M Angrist; R Salomon; D Croaker; C H Buys; S Lyonnet; A Chakravarti
Journal: Proc Natl Acad Sci U S A Date: 2000-01-04 Impact factor: 11.205

10. Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing.

Authors: P Komminoth; E Kunz; O Hiort; S Schröder; X Matias-Guiu; G Christiansen; J Roth; P U Heitz
Journal: Am J Pathol Date: 1994-10 Impact factor: 4.307

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

1. A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.

Review 2. [Molecular biology, basic research and diagnosis of Hirschsprung's disease].

3. Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism.

Review 4. An analysis of vertebrate mRNA sequences: intimations of translational control.

Review 5. The RET proto-oncogene: a challenge to our understanding of disease pathogenesis.

6. Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions.

7. Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

8. Functional RET G691S polymorphism in cutaneous malignant melanoma.

9. Parent-of-origin effects in multiple endocrine neoplasia type 2B.

10. Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing.