Effects of Fusobacterium necrophorum on the mesenteric microcirculation of guinea pigs.

Thrombi formation was demonstrated in mesenteric microcirculation of guinea pigs inoculated with Fusobacterium necrophorum and the bacterial hemagglutinin (HA). The thrombi were initially observed in venules and later, in arterioles. Immunofluorescence study revealed that the HA bound to the thrombi in the microcirculation. These results indicate that thrombosis is an early step in the pathogenesis of necrosis.