M Nilsson1, T H Sandberg1, J L Poulsen1, M Gram1, J B Frøkjaer2,3, L R Østergaard4, K Krogh5, C Brock1,6, A M Drewes1,3. 1. Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark. 2. Mech-Sense, Department of Radiology, Aalborg University Hospital, Aalborg, Denmark. 3. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 4. Department of Health Science and Technology, Aalborg University, Aalborg, Denmark. 5. Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. 6. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: Segmental distribution of colorectal volume is relevant in a number of diseases, but clinical and experimental use demands robust reliability and validity. Using a novel semi-automatic magnetic resonance imaging-based technique, the aims of this study were to describe: (i) inter-individual and intra-individual variability of segmental colorectal volumes between two observations in healthy subjects and (ii) the change in segmental colorectal volume distribution before and after defecation. METHODS: The inter-individual and intra-individual variability of four colorectal volumes (cecum/ascending colon, transverse, descending, and rectosigmoid colon) between two observations (separated by 52 ± 10) days was assessed in 25 healthy males and the effect of defecation on segmental colorectal volumes was studied in another seven healthy males. KEY RESULTS: No significant differences between the two observations were detected for any segments (All p > 0.05). Inter-individual variability varied across segments from low correlation in cecum/ascending colon (intra-class correlation coefficient [ICC] = 0.44) to moderate correlation in the descending colon (ICC = 0.61) and high correlation in the transverse (ICC = 0.78), rectosigmoid (ICC = 0.82), and total volume (ICC = 0.85). Overall intra-individual variability was low (coefficient of variance = 9%). After defecation the volume of the rectosigmoid decreased by 44% (p = 0.003). The change in rectosigmoid volume was associated with the true fecal volume (p = 0.02). CONCLUSIONS & INFERENCES: Imaging of segmental colorectal volume, morphology, and fecal accumulation is advantageous to conventional methods in its low variability, high spatial resolution, and its absence of contrast-enhancing agents and irradiation. Hence, the method is suitable for future clinical and interventional studies and for characterization of defecation physiology.
BACKGROUND: Segmental distribution of colorectal volume is relevant in a number of diseases, but clinical and experimental use demands robust reliability and validity. Using a novel semi-automatic magnetic resonance imaging-based technique, the aims of this study were to describe: (i) inter-individual and intra-individual variability of segmental colorectal volumes between two observations in healthy subjects and (ii) the change in segmental colorectal volume distribution before and after defecation. METHODS: The inter-individual and intra-individual variability of four colorectal volumes (cecum/ascending colon, transverse, descending, and rectosigmoid colon) between two observations (separated by 52 ± 10) days was assessed in 25 healthy males and the effect of defecation on segmental colorectal volumes was studied in another seven healthy males. KEY RESULTS: No significant differences between the two observations were detected for any segments (All p > 0.05). Inter-individual variability varied across segments from low correlation in cecum/ascending colon (intra-class correlation coefficient [ICC] = 0.44) to moderate correlation in the descending colon (ICC = 0.61) and high correlation in the transverse (ICC = 0.78), rectosigmoid (ICC = 0.82), and total volume (ICC = 0.85). Overall intra-individual variability was low (coefficient of variance = 9%). After defecation the volume of the rectosigmoid decreased by 44% (p = 0.003). The change in rectosigmoid volume was associated with the true fecal volume (p = 0.02). CONCLUSIONS & INFERENCES: Imaging of segmental colorectal volume, morphology, and fecal accumulation is advantageous to conventional methods in its low variability, high spatial resolution, and its absence of contrast-enhancing agents and irradiation. Hence, the method is suitable for future clinical and interventional studies and for characterization of defecation physiology.
Authors: Paul T Heitmann; Paul F Vollebregt; Charles H Knowles; Peter J Lunniss; Phil G Dinning; S Mark Scott Journal: Nat Rev Gastroenterol Hepatol Date: 2021-08-09 Impact factor: 46.802
Authors: Jakob L Poulsen; Esben B Mark; Christina Brock; Jens B Frøkjær; Klaus Krogh; Asbjørn M Drewes Journal: J Neurogastroenterol Motil Date: 2018-01-30 Impact factor: 4.924
Authors: Maura Corsetti; Marcello Costa; Gabrio Bassotti; Adil E Bharucha; Osvaldo Borrelli; Phil Dinning; Carlo Di Lorenzo; Jan D Huizinga; Marcel Jimenez; Satish Rao; Robin Spiller; Nick J Spencer; Roger Lentle; Jasper Pannemans; Alexander Thys; Marc Benninga; Jan Tack Journal: Nat Rev Gastroenterol Hepatol Date: 2019-07-11 Impact factor: 46.802
Authors: Hayfa Sharif; Caroline L Hoad; Nichola Abrehart; Penny A Gowland; Robin C Spiller; Sian Kirkham; Sabarinathan Loganathan; Michalis Papadopoulos; Marc A Benninga; David Devadason; Luca Marciani Journal: Diagnostics (Basel) Date: 2021-05-28
Authors: Anne E Olesen; Debbie Grønlund; Esben B Mark; Klaus Krogh; Jens B Frøkjær; Asbjørn M Drewes Journal: J Neurogastroenterol Motil Date: 2019-10-30 Impact factor: 4.924