| Literature DB >> 26597760 |
Abstract
The extracellular matrix in the healthy breast has an important tumor suppressive role, whereas the abnormal ECM in tumors can promote aggressiveness, and has been linked to breast cancer relapse, survival and resistance to chemotherapy. This review article gives an overview of the elements of the ECM which have been linked to prognosis of breast cancers, including changes in ECM protein composition, splicing, and microstructure. Published by Elsevier Inc.Entities:
Keywords: Breast cancer; Extracellular matrix; Microstructure; Splicing
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Year: 2015 PMID: 26597760 DOI: 10.1016/j.yexcr.2015.11.009
Source DB: PubMed Journal: Exp Cell Res ISSN: 0014-4827 Impact factor: 3.905