Literature DB >> 26597428

Role of dendritic cell-pathogen interactions in the immune response to pulmonary cryptococcal infection.

Alison J Eastman1,2, John J Osterholzer1,2,3, Michal A Olszewski1,2,3.   

Abstract

This review discusses the unique contributions of dendritic cells (DCs) to T-cell priming and the generation of effective host defenses against Cryptococcus neoformans (C.neo) infection. We highlight DC subsets involved in the early and later stages of anticryptococcal immune responses, interactions between C.neo pathogen-associated molecular patterns and pattern recognition receptors expressed by DC, and the influence of DC on adaptive immunity. We emphasize recent studies in mouse models of cryptococcosis that illustrate the importance of DC-derived cytokines and costimulatory molecules and the potential role of DC epigenetic modifications that support maintenance of these signals throughout the immune response to C.neo. Lastly, we stipulate where these advances can be developed into new, immune-based therapeutics for treatment of this global pathogen.

Entities:  

Keywords:  Cryptococcus neoformans; TLR9; TNF-α; cryptococcal virulence factors; dendritic cells; epigenetics; mouse model

Mesh：

Substances：

Year:  2015        PMID： 26597428      PMCID： PMC5720351          DOI： 10.2217/fmb.15.92

Source DB:  PubMed          Journal:  Future Microbiol        ISSN： 1746-0913            Impact factor:   3.165


  195 in total

1.  Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.

Authors:  A Vecchiarelli; C Retini; C Monari; C Tascini; F Bistoni; T R Kozel
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

Review 2.  HIV-associated cryptococcal meningitis.

Authors:  Joseph N Jarvis; Thomas S Harrison
Journal:  AIDS       Date:  2007-10-18       Impact factor: 4.177

3.  MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

Authors:  R Medzhitov; P Preston-Hurlburt; E Kopp; A Stadlen; C Chen; S Ghosh; C A Janeway
Journal:  Mol Cell       Date:  1998-08       Impact factor: 17.970

4.  Mannoproteins from Cryptococcus neoformans promote dendritic cell maturation and activation.

Authors:  Donatella Pietrella; Cristina Corbucci; Stefano Perito; Giovanni Bistoni; Anna Vecchiarelli
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

5.  Contribution of tumour necrosis factor-alpha (TNF-alpha) in host defence mechanism against Cryptococcus neoformans.

Authors:  K Kawakami; X Qifeng; M Tohyama; M H Qureshi; A Saito
Journal:  Clin Exp Immunol       Date:  1996-12       Impact factor: 4.330

6.  Cryptococcus neoformans. II. Phagocytosis by human leukocytes.

Authors:  G S Bulmer; M D Sans
Journal:  J Bacteriol       Date:  1967-11       Impact factor: 3.490

7.  Effects of tumor necrosis factor alpha on dendritic cell accumulation in lymph nodes draining the immunization site and the impact on the anticryptococcal cell-mediated immune response.

Authors:  Sean K Bauman; Gary B Huffnagle; Juneann W Murphy
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

8.  Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation.

Authors:  Sarah E Hardison; Gina Herrera; Mattie L Young; Camaron R Hole; Karen L Wozniak; Floyd L Wormley
Journal:  J Immunol       Date:  2012-09-14       Impact factor: 5.422

9.  The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity.

Authors:  Wendy A Szymczak; George S Deepe
Journal:  J Immunol       Date:  2009-07-08       Impact factor: 5.422

10.  TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.

Authors:  Daniela Palacios; Chiara Mozzetta; Silvia Consalvi; Giuseppina Caretti; Valentina Saccone; Valentina Proserpio; Victor E Marquez; Sergio Valente; Antonello Mai; Sonia V Forcales; Vittorio Sartorelli; Pier Lorenzo Puri
Journal:  Cell Stem Cell       Date:  2010-10-08       Impact factor: 24.633
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  11 in total

1.  T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.

Authors:  Lori M Neal; Yafeng Qiu; Jooho Chung; Enze Xing; Woosung Cho; Antoni N Malachowski; Ashley R Sandy-Sloat; John J Osterholzer; Ivan Maillard; Michal A Olszewski
Journal:  J Immunol       Date:  2017-06-14       Impact factor: 5.422

2.  Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection.

Authors:  Seagal Teitz-Tennenbaum; Steven P Viglianti; Jonathan A Roussey; Stuart M Levitz; Michal A Olszewski; John J Osterholzer
Journal:  J Immunol       Date:  2018-08-10       Impact factor: 5.422

3.  Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.

Authors:  Jintao Xu; Adam Flaczyk; Lori M Neal; Zhenzong Fa; Alison J Eastman; Antoni N Malachowski; Daphne Cheng; Bethany B Moore; Jeffrey L Curtis; John J Osterholzer; Michal A Olszewski
Journal:  J Immunol       Date:  2017-03-15       Impact factor: 5.422

4.  Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

Authors:  M A Alobaid; S-J Richards; M R Alexander; M I Gibson; A M Ghaemmaghami
Journal:  Mater Today Bio       Date:  2020-09-30

5.  Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection.

Authors:  Jintao Xu; Alison J Eastman; Adam Flaczyk; Lori M Neal; Guolei Zhao; Jacob Carolan; Antoni N Malachowski; Valerie R Stolberg; Mohammed Yosri; Stephen W Chensue; Jeffrey L Curtis; John J Osterholzer; Michal A Olszewski
Journal:  MBio       Date:  2016-07-12       Impact factor: 7.867

6.  Innate Immune Responses to Cryptococcus.

Authors:  Lena J Heung
Journal:  J Fungi (Basel)       Date:  2017-07-02

7.  RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis.

Authors:  Zhenzong Fa; Qun Xie; Wei Fang; Haibing Zhang; Haiwei Zhang; Jintao Xu; Weihua Pan; Jinhua Xu; Michal A Olszewski; Xiaoming Deng; Wanqing Liao
Journal:  Front Immunol       Date:  2017-09-01       Impact factor: 7.561

8.  Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias.

Authors:  Jintao Xu; Adam Flaczyk; Lori M Neal; Zhenzong Fa; Daphne Cheng; Mike Ivey; Bethany B Moore; Jeffrey L Curtis; John J Osterholzer; Michal A Olszewski
Journal:  Front Immunol       Date:  2017-09-28       Impact factor: 7.561

Review 9.  Resistance and Tolerance to Cryptococcal Infection: An Intricate Balance That Controls the Development of Disease.

Authors:  Mitra Shourian; Salman T Qureshi
Journal:  Front Immunol       Date:  2019-01-29       Impact factor: 7.561

Review 10.  Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans.

Authors:  Benjamin N Nelson; Ashlee N Hawkins; Karen L Wozniak
Journal:  Front Cell Infect Microbiol       Date:  2020-02-11       Impact factor: 5.293
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