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Literature DB >> 26597109

Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.

Yangyang Wang¹, Xinhui Wang¹, Cristina R Ferrone¹, Joseph H Schwab², Soldano Ferrone³.

Abstract

This review discusses the potential use of intracellular tumor antigens as targets of antibody-based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed.

Entities: Disease

Keywords: Grp78; Grp94; Hsp70; Intracellular tumor antigen; Monoclonal antibodies; PRL-3

Mesh：

Substances：
Antigens, Neoplasm

Year: 2015 PMID： 26597109 PMCID： PMC5528737 DOI： 10.1016/j.molonc.2015.10.019

Source DB: PubMed Journal: Mol Oncol ISSN： 1574-7891 Impact factor: 6.603

121 in total

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Authors: Mario Gonzalez-Gronow; Maria Angelica Selim; John Papalas; Salvatore V Pizzo
Journal: Antioxid Redox Signal Date: 2009-09 Impact factor: 8.401

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