Pooja Ghatalia1, Charity J Morgan2, Guru Sonpavde3. 1. Department of Internal Medicine, University of Alabama at Birmingham (UAB), AL, United States. 2. Department of Biostatistics, UAB School of Medicine, United States. 3. Department of Internal Medicine, Section of Medical Oncology, UAB Medical Center, United States. Electronic address: gsonpavde@uabmc.edu.
Abstract
BACKGROUND: A meta-analysis of prospective trials systematically investigated regression of advanced solid tumors in patients receiving placebo or no anticancer therapy to inform on spontaneous regressions. PATIENT AND METHODS: Arms of randomized controlled trials (RCTs) of metastatic solid tumors receiving placebo or no anti-cancer therapy were used. Statistical analyses were conducted to calculate the overall response rate (ORR) and to detect differentials based on histology, progression at baseline and prior therapies. RESULTS: A total of 7676 patients were evaluable from 61 RCTs evaluating 18 solid tumors. The ORR was 1.95% (95% CI: 1.52-2.48%). There was no significant effect of histology (p=0.110), baseline progressive disease (p>0.20) or the line of therapy (p>0.20) on ORR. CONCLUSIONS: Spontaneous regressions are seen across all advanced solid tumors. Some malignancies demonstrated higher rates of spontaneous regressions and may be relatively immunotherapy responsive.
BACKGROUND: A meta-analysis of prospective trials systematically investigated regression of advanced solid tumors in patients receiving placebo or no anticancer therapy to inform on spontaneous regressions. PATIENT AND METHODS: Arms of randomized controlled trials (RCTs) of metastatic solid tumors receiving placebo or no anti-cancer therapy were used. Statistical analyses were conducted to calculate the overall response rate (ORR) and to detect differentials based on histology, progression at baseline and prior therapies. RESULTS: A total of 7676 patients were evaluable from 61 RCTs evaluating 18 solid tumors. The ORR was 1.95% (95% CI: 1.52-2.48%). There was no significant effect of histology (p=0.110), baseline progressive disease (p>0.20) or the line of therapy (p>0.20) on ORR. CONCLUSIONS: Spontaneous regressions are seen across all advanced solid tumors. Some malignancies demonstrated higher rates of spontaneous regressions and may be relatively immunotherapy responsive.
Authors: Arthur E Frankel; Sachin Deshmukh; Amit Reddy; John Lightcap; Maureen Hayes; Steven McClellan; Seema Singh; Brooks Rabideau; T Grant Glover; Bruce Roberts; Andrew Y Koh Journal: Integr Cancer Ther Date: 2019 Jan-Dec Impact factor: 3.279